Abstract: A substrate retaining apparatus, a load lock assembly comprising the substrate retaining apparatus, and a system including the substrate retaining apparatus are disclosed. The substrate retaining apparatus can include at least one sidewall and one or more heat shields. One or more of the at least one sidewall can include a cooling fluid conduit to facilitate cooling of substrates retained by the substrate retaining apparatus. Additionally or alternatively, one or more of the at least one sidewall can include a gas conduit to provide gas to a surface of a retained substrate.

Abstract: This disclosure relates to compositions and methods for treating cancer using chimeric antigen receptor T cells and/or antigen binding domains targeting CLDN18.2.

Abstract: A drug delivery drive mechanism including a ratchet wheel including a plurality of teeth, a ratchet arm including a first prong and a second prong, wherein the first prong is operable interact with a tooth of the plurality of teeth to rotate the ratchet wheel in a circular direction, and the second prong is operable to interact with another tooth of the plurality of teeth to further rotate the ratchet wheel in the circular direction.

Abstract: Methods and apparatus to prevent trailer sway are disclosed. An example apparatus to prevent trailer sway of a trailer coupled to a vehicle includes prediction circuitry to predict, based on sensor data from one or more sensors of the vehicle, whether a trailer sway condition associated with the vehicle is likely to occur, and control activation circuitry to, in response to the prediction that the trailer sway is likely to occur, activate at least one vehicle control of the vehicle to prevent the trailer sway condition from occurring, the at least one vehicle control to include applying torque to at least one of one or more trailer wheels of the trailer or one or more vehicle wheels of the vehicle.

Abstract: An orthopedic implant with an inferior portion having a tibia contact surface configured to extend over a tibia; a superior portion opposite to the inferior portion having a tendon contact surface configured to change a position of a patellar tendon by lifting or tilting the patellar tendon when the curved surface of the first portion is engaged with the tibia; and a fixation mechanism adapted to attach the orthopedic implant to the tibia, the orthopedic implant being further configured to change shape from a first configuration to a second configuration in response to a load applied between the tendon contact surface and the tibia contact surface. The invention also addresses corresponding methods.

Abstract: A processing system including at least one processor may detect a first location and a first orientation of an augmented reality endpoint device of a user at a venue, identify an entryway of a first enclosed space of the venue that is within a first field-of-view of the augmented reality endpoint device in accordance with the first location and the first orientation of the augmented reality endpoint device, and present, via the augmented reality endpoint device, first visual information of the first enclosed space. The first visual information may include first imagery of the first enclosed space and may be presented within the first field-of-view.

Abstract: A system deletes and sanitizes files in a distributed file system. The system also randomizes rotation of data in a distributed file system.

Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.

Abstract: A system for automatically generating computer-executable code includes a user device including a communications interface, a code generation module, and a data store, and a storage device operatively coupled to the code generation module via a network and the communications interface. The storage device includes a relational database management system. The code generation module is configured to parse a selected feature from the feature library to determine a first helper function of the one or more helper functions and a selected template function of the one or more template functions, receive a first argument for the first helper function, generate a first output value by associating the first helper function with the first argument, generate precursor executable code by adding the first output value to the selected template function as a first argument of the selected template function, and execute the precursor executable code to generate bespoke code.

Abstract: The concepts and technologies disclosed herein are directed to guidance rule-based compliance management. According to one aspect disclosed herein, an integrated technology catalog system (“system”) can provide an interface through which a technology catalog can be accessed to view a technology product and evaluate the technology product in a given context. The system can receive, via the interface, a request to evaluate the technology product in the given context. In response to the request, the system can identify whether at least one guidance rule is applicable to the technology product in the given context. In response to identifying that the at least one guidance rule is applicable to the technology product in the given context, the system can generate a report for the technology product. The report can include all applicable guidance rules for the technology product. The system can output the report.

Abstract: The disclosure relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain.

Abstract: A container device and methods of operation and assembly of the same are provided. The container device is formed from a foldable material and includes interior locking mechanisms that prevent an inner box from being removed from an outer cover unless a user depresses a portion of the outer box to disengage an internal locking mechanism. A secondary locking mechanism prevents the inner box from being removed entirely from the outer cover.

Abstract: A system for interfacing predetermined services to a user at a fixed location includes a processing platform running an operating system. The system further includes a data store for storing configuration information for enabling the operating system to interface with available physical system resources through the physical system resource interface associated therewith. A communication resource for interfacing with the operating system allows communication of the operating system with a central office for downloading configuration information to selectively enable ones of the available physical system resources to interface with the operating system through associated ones of the physical system resource interfaces in accordance with the configuration information and the predetermined service selected by a user. A plurality of configurations is stored in the data store, and each is associated with a predetermined service and one or more of the available physical system resources.

Abstract: A downhole tool for sealing a well includes a push ring, a first slip ring located adjacent to the push ring, a first wedge located adjacent to the first slip ring and configured to radially push the first slip ring and separate the first slip ring into individual parts, and a sealing element located adjacent to the first wedge and configured to seal the well. An upstream end of the first slip ring and a downstream end of the push ring form a wavy interface when in contact. The wavy interface locks the first slip ring relative to the push ring to prevent a rotation of the first slip ring relative to the push ring.

Abstract: An apparatus includes first and second pluralities of switches, a controller for controlling these switches, gate-drivers for driving switches from the first plurality of switches, and first and second terminals configured for coupling to corresponding first and second external circuits at corresponding first and second voltages. During operation, the controller causes the first plurality of switches to transition between states. These transitions result in the second voltage being maintained at a value that is a multiple of the first voltage. The controller also causes the second plurality of switches to transition between states. These transitions resulting in capacitors being coupled or decoupled from the second voltage. The gate drivers derive, from the capacitors, charge for causing a voltage that enables switches from the first plurality of switches to be driven.

Abstract: Aspects of the present invention relate to an injection device comprising a syringe carrier configured to receive a medicament container, a housing having a proximal end and a distal end; the housing being configured to receive the syringe carrier and releasably engage the proximal end of the syringe carrier and a proximal end cap arranged to engage with the proximal end of the housing and comprising a wall extending distally along the housing, the proximal end cap configured to maintain the engagement between the proximal end of the syringe carrier and the housing.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: The invention features compositions and methods for treating developmental, neurodevelopmental (e.g., Fragile X syndrome (FXS)) or Down syndrome (DS) or neurodegenerative disorders (e.g., Alzheimer's disease (AD)) by increasing expression of Fragile X Mental Retardation Protein (FMRP) in patients having such disorders.

Abstract: A carbon capture system using an efficient method of capturing carbon dioxide is disclosed herein. The carbon capture system described is scalable in shape and size and can be adjusted to achieve different volumes of airflow. This method is efficient due to the maximum surface area to volume ratio achievable in a carbon capture system with the distribution of equally or randomly spaced spray nozzles configured to inject electrically charged carbon capture fluid throughout the interior of the system. The fluid interacts and then combines with air and as a result, large amounts of carbon dioxide are captured within the system. The finer the particulate of carbon capture fluid, the larger the volume ratio which results in an efficient carbon capture system.

Abstract: This disclosure is generally directed to systems and methods related to providing assistance services to a disabled vehicle. In an example embodiment, a method executed by a first processor in a vehicle may involve detecting an event that places the vehicle in a disabled condition; transmitting information associated with the event to a second processor; and detecting an arrival of a assistance vehicle that is dispatched by the second processor based on an automated evaluation of the information associated with the event. The second processor, which can be, for example, a part of a server computer, may evaluate the information in order to identify an assistance vehicle having equipment for providing the assistance service. In an example scenario, the disabled vehicle and/or the assistance vehicle can be an autonomous vehicle.