Abstract: An Ethernet switch and a switch microcontroller or CPU are integrated onto a system-on-a-chip (SoC). The Ethernet switch remains independently operating at full speed even though the remainder of the SoC is being reset or is otherwise nonoperational. The Ethernet switch is on a separated power and clock domain from the remainder of the integrated SoC. A warm reset signal is trapped by control microcontroller (MCU) to allow the switch CPU to isolate the Ethernet switch and save state. When the Ethernet switch is isolated and operating independently, the warm reset request is provided to the other entities on the integrated SoC. When warm reset is completed, the state is restored and the various DMA and flow settings redeveloped in the integrated SoC to allow return to normal operating condition.

Abstract: Agents having cytotoxic activity, as well as compositions, uses, and methods relating thereto, are described herein. Certain steroid acid-peptide conjugates or moieties have the ability to induce killing or inhibition of proliferation of mammalian cells, in vitro or in vivo upon administration to a subject. The steroid acid-peptide conjugates include bile acids and bile acid analogs and peptides that may include a nuclear localisation signal or a portion thereof. Also described herein is a method for treating cancer, an autoimmune disease, or any other disease or disorder ameliorated by treatment with an antiproliferative drug in a subject in a subject with the cytotoxic agents described herein.

Abstract: A hinge assembly includes a first hinged body, a pivot pin assembly, and a second hinged body. The first hinged body includes a channel. The pivot pin assembly includes a pin body configured to slideably engage the channel. The pivot pin assembly may be translated within the channel and adjustably secured along the channel. The pin body includes a downwardly extending pin. The second hinged body comprises a pin aperture configured to cooperatively receive the pin. The first hinged body and the second hinged body are configured to hingedly pivot along a hinge axis defined by the pin when the pin is received in the pin aperture. The pin body may include a pin body aperture configured to receive an alignment fastener such that the pin body may be tilt adjusted relative to the first hinged body.

Abstract: An electronic system includes a first data retriever to communicate with a first database associated with an analytic tool, and a second data retriever to communicate with a second database associated with an electronic testing device; wherein the analytic tool is configured to store information regarding actual usage of a product in the first database; wherein the electronic testing device is configured to store product testing data for the product in the second database; wherein the first data retriever comprises a first communication interface to electronically receive the information; wherein the second data retriever comprises a second communication interface to electronically receive the product testing data; and wherein the electronic system further comprises a processing unit configured to compute a score indicating a quality of product testing for the product based on the information regarding the actual usage of the product and/or the product testing data.

Abstract: A method of de-mosaicing pixel data from an image processor includes generating a pixel block that includes a plurality of image pixels. The method also includes determining a first image gradient between a first set of pixels of the pixel block and a second image gradient between a second set of pixels of the pixel block. The method also includes determining a first adaptive threshold value based on intensity of a third set of pixels of the pixel block. The pixels of the third set of pixels are adjacent to one another. The method also includes filtering the pixel block in a vertical, horizontal, or neutral direction based on the first and second image gradients and the first adaptive threshold value utilizing a plurality of FIR filters to generate a plurality of component images.

Abstract: Described herein are methods for the expression and purification of Cas13a and methods for detecting target RNA using Cas13a.

Abstract: A method for generating a trajectory for a vehicle based on an abstract space of control parameters associated with the vehicle may include applying a machine learning model to determine an abstract space representation of the trajectory, which includes a sequence of control parameters associated with the vehicle. For instance, application of the machine learning model may include performing a search of the abstract space parameterized by control parameters that include derivatives of the position of the vehicle. Examples of control parameters include velocity, acceleration, jerk, and snap. A physical space representation of the trajectory may be determined by at least mapping the sequence of control parameters to a sequence of positions for the vehicle. A motion of the vehicle may be controlled based at least on the physical space representation of the trajectory. Related systems and computer program products are also provided.

Abstract: An atomizer having an atomizer head configured to atomize a first fluid. The atomizer includes, in addition, a measurement module including at least one sensor configured to measure the values of at least one parameter of the atomizer, an electronic control module configured to receive the measured values, and a power supply configured to electrically supply the control module with a power supply voltage.

Abstract: A vibratory conveyor includes a feed tray, an electromagnetic linear actuator and a movable drive train interconnecting the feed tray and the electromagnetic linear actuator such that the electromagnetic linear actuator will move the feed tray during energization of the electromagnetic linear actuator. A sensor assembly is positioned to detect movement of the electromagnetic linear actuator. A controller connected to receive an output of the sensor assembly and connected to control energization of electromagnetic linear actuator, wherein the controller is configured to adjust energization of the electromagnetic linear actuator based upon the output of the sensor assembly. A vibratory conveyor in which the movable drive train includes at least one parallel spring element therealong is also disclosed.

Abstract: Agents having cytotoxic activity, as well as compositions, uses, and methods relating thereto, are described herein. Certain steroid acid-peptide conjugates or moieties have the ability to induce killing or inhibition of proliferation of mammalian cells, in vitro or in vivo upon administration to a subject. The steroid acid-peptide conjugates include bile acids and bile acid analogs and peptides that may include a nuclear localisation signal or a portion thereof. Also described herein is a method for treating cancer, an autoimmune disease, or any other disease or disorder ameliorated by treatment with an antiproliferative drug in a subject in a subject with the cytotoxic agents described herein.

Abstract: The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide production which destabilize endosome-lysosome membrane. The conjugated compound can further comprise payload.

Abstract: The invention relates to a method for application of coverage product on a surface using a print head that is mounted on a robot arm, and that is made up of a body equipped with at least one printing nozzle. The method includes a) defining a strip of surface to be coated, b) defining a trajectory for the strip of surface, the trajectory including a succession of reference points, c) removing a strip of surface from an information sheet modelling the surface to be coated, d) restarting at a) until the modelled surface to be coated becomes a null area, e) defining an activation program for each print head nozzle on each trajectory, and f) applying the coverage product by activating each print head nozzle on the different trajectories depending on the orientation of the print head at each reference point, based on the activation program.

Abstract: Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.

Abstract: A method for routing computer messages between parties is provided. The method is implemented using a message gateway computing system including a processor and a memory. The method includes receiving a message routing offer from a seller and representing an offer to process payment card transactions. The method also includes receiving a message routing request from a buyer. The method further includes first message route between the buyer party and a first seller party of the plurality of seller parties on a message processing network. The method also includes receiving a payment card transaction from the buyer party. The method further includes identifying the first message route associated with the payment card transaction. The method also includes transmitting the payment card transaction to the first seller party based at least in part on the first message route.

Abstract: An Ethernet switch and a switch microcontroller or CPU are integrated onto a system-on-a-chip (SoC). The Ethernet switch remains independently operating at full speed even though the remainder of the SoC is being reset or is otherwise nonoperational. The Ethernet switch is on a separated power and clock domain from the remainder of the integrated SoC. A warm reset signal is trapped by control microcontroller (MCU) to allow the switch CPU to isolate the Ethernet switch and save state. When the Ethernet switch is isolated and operating independently, the warm reset request is provided to the other entities on the integrated SoC. When warm reset is completed, the state is restored and the various DMA and flow settings redeveloped in the integrated SoC to allow return to normal operating condition.

Abstract: A bug screen frame assembly includes a front frame portion defining an exterior of the bug screen frame assembly, a rear frame portion received by the front frame portion, and a mesh screen captured between the front frame portion and the rear frame portion. One of the front frame portion and the rear frame portion includes a plurality of spikes extending toward the other of the front frame portion and the rear frame portion, and the other of the front frame portion and the rear frame portion comprises a groove that receives the spikes. The spikes extend through the mesh screen to retain the mesh screen. The overall assembly has a clean appearance with a self-tensioning screen without any visible clamps or screws.

Abstract: A synchronization circuit includes a first synchronizer having a first data input, a first clock input, and first output; a second synchronizer having a second data input, a second clock input, and a second output; selection circuitry having first, second, third and fourth inputs, and a synchronized data output, the first and second inputs coupled to the first and second outputs, respectively; and storage circuitry having a storage data input coupled to the synchronized data output, a third clock input, and a feedback output coupled to the fourth input.