Patents by Inventor A. C. Matin

A. C. Matin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agents specifically delivered by exosomes for cancer treatment
    Patent number: 11517530
    Abstract: Provided herein are extracellular vesicle (EV) (a.k.a. exosome) compositions for specifically targeting the delivery of a therapeutic agent to particular cells and/or tissues in a subject, as well as methods of making and methods of using said compositions. The compositions and methods disclosed herein are useful for targeted drug delivery in the treatment of diseases in which a cell surface receptor is overexpressed, such as, for example, cancer.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: December 6, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jing-Hung Wang, Alexis Forterre, A. C. Matin, Alain Delcayre
  • THERAPEUTIC AGENTS SPECIFICALLY DELIVERED BY EXOSOMES FOR CANCER TREATMENT
    Publication number: 20210161817
    Abstract: Provided herein are extracellular vesicle (EV) (a.k.a. exosome) compositions for specifically targeting the delivery of a therapeutic agent to particular cells and/or tissues in a subject, as well as methods of making and methods of using said compositions. The compositions and methods disclosed herein are useful for targeted drug delivery in the treatment of diseases in which a cell surface receptor is overexpressed, such as, for example, cancer.
    Type: Application
    Filed: September 25, 2018
    Publication date: June 3, 2021
    Inventors: Jing-Hung Wang, Alexis Forterre, A.C. Matin, Alain Delcayre
  • Nitroreductase enzymes for bioremediation
    Patent number: 7754470
    Abstract: Compositions and methods are provided for bioremediation of toxic metals.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: July 13, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: A. C. Matin, Yoram Barak, David F. Ackerley
  • MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE
    Publication number: 20100135912
    Abstract: Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. Magnetospirillum magneticum AMB-1 produces positive MRI contrast when generating ultrasmall magnetite particles (10-40 nm diameter). Positive MRI contrast permits clearer distinction from image voids compared to negative contrast. T1-weighted MRI showed that such bacteria increased positive contrast 2.2-fold (p<0.02) in vitro and 2.0-fold (p<0.02) following intratumoral injection in mouse tumor xenografts. Upon intravenous delivery, Magnetospirillum magneticum AMB-1 targeted tumors and generated increased positive MRI contrast in them (1.4-fold; p<0.01). AMB-1 tumor targeting was shown by viable counts, microPET imaging of radio-labeled AMB-1, and Prussian blue staining of tumor sections. Thus, magnetotactic bacteria provide a tool for improving cancer diagnosis and monitoring treatment response by MRI.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Inventors: Sanjiv S. Gambhir, Michael Benoit, A. C. Matin, Yoram Barak, Shay Keren, Dirk Mayer
  • Nitroreductase enzymes
    Patent number: 7687474
    Abstract: Compositions and methods are provided for the treatment of cancer.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: March 30, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: A. C. Matin, Yoram Barak, Susan V. Lynch, David F. Ackerley, Stephen H. Thorne, Christopher H. Contag, Jianghong Rao
  • IMPROVED NITROREDUCTASE ENZYMES FOR BIOREMEDIATION
    Publication number: 20070254355
    Abstract: Compositions and methods are provided for bioremediation of toxic metals.
    Type: Application
    Filed: December 20, 2006
    Publication date: November 1, 2007
    Inventors: A.C. Matin, Yoram Barak, David Ackerley
  • IMPROVED NITROREDUCTASE ENZYMES
    Publication number: 20070254852
    Abstract: Compositions and methods are provided for the treatment of cancer.
    Type: Application
    Filed: December 20, 2006
    Publication date: November 1, 2007
    Inventors: A.C. Matin, Yoram Barak, Susan Lynch, David Ackerly, Stephen Thorne, Christopher Contag, Jianghong Rao