Patents by Inventor A. Christopher Skjold

A. Christopher Skjold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analytical process and agents for the detection of esterolytic and/or proteolytic enzymes
    Patent number: 4758508
    Abstract: Agent for the detection of esterolytic and/or proteolytic enzymes, containing (a) an amino acid ester or peptide ester of a phenol, as the chromogenic enzyme substrate, and (b) an alcohol as the substance which accelerates the enzymatic cleavage of the amino acid ester bond or peptide ester bond of component (a), characterized in that it contains a salt as the accelerating substance.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 19, 1988
    Assignee: Miles Inc.
    Inventors: Eugen Schnabel, James Travis, A. Christopher Skjold
  • Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
    Patent number: 4657855
    Abstract: A composition for determining the presence of leukocytes, esterase or protease in a test sample. The composition comprises an ester having the structure ##STR1## in which: A is an N-blocked-amino acid residue or an N-blocked-peptide residue, X is O, S or NR', R is aryl, or lower alkyl, R* is H, or lower alkyl, and R' is H, lower alkyl or aryl; and a suitable buffer substance.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: April 14, 1987
    Assignee: Miles Laboratories, Inc.
    Inventors: Paul F. Corey, A. Christopher Skjold, James H. Pendergrass, Lonnie Stover
  • Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
    Patent number: 4637979
    Abstract: A composition and test device for determining the presence of an analyte selected from leukocytes, esterase and protease in a test sample. The composition comprises an ester capable of producing a detectable response upon interaction with said analyte, and a diazonium salt having the structure ##STR1## in which A.sup.- is an anion, and R same or differ, is H, lower alkyl, aryl, or both of R together form a fused ring system, and in which R' is H, OH or lower alkyl.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: January 20, 1987
    Assignee: Miles Laboratories, Inc.
    Inventors: A. Christopher Skjold, Herbert Hugl, Gerhard Wolfrum
  • Test for esterase activity in a liquid sample
    Patent number: 4499185
    Abstract: A composition, test device and method for determining the presence of leukocytes, esterase and/or esterase activity in a test sample is disclosed. The composition comprises an ester which, when cleaved by esterolytic activity, produces a detectable response such as color formation. In addition the composition comprises the compound 3-quinuclidinol. The device is prepared by incorporating a carrier matrix, such as paper, with the composition. The method comprises contacting a test sample with the device and observing a detectable response.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: February 12, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: A. Christopher Skjold, Lonnie R. Stover, Robert W. Trimmer