Abstract: Novel compounds having formula (I) and methods of using these compounds to treat diseases, conditions, and disorders are described.

Abstract: Various embodiments of the present disclosure include a system, method, and apparatus for increased control of steam injection for use in oil and gas recovery in a well. Embodiments can comprise a plurality of controllable zones of injection disposed in the well. The plurality of controllable zones include a primary conduit that houses a plurality of concentric conduits of decreasing diameter disposed inside of the primary conduit. In some embodiments, each of the concentric conduits includes a proximal end and a distal end. In some embodiments, each of the plurality of concentric conduits are fluidly sealed from one another from their respective proximal end to distal end.

Abstract: A surgical instrument comprising an articulatable end effector and a control system that controls the articulation of the end effector and provides feedback to the user of the surgical instrument.

Abstract: A computer model is trained to account for data samples in a high-dimensional space as lying on different manifolds, rather than a single manifold to represent the data set, accounting for the data set as a whole as a union of manifolds. Different data samples that may be expected to belong to the same underlying manifold are determined by grouping the data. For generative models, a generative model may be trained that includes a sub-model for each group trained on that group's data samples, such that each sub-model can account for the manifold of that group. The overall generative model includes information describing the frequency to sample from each sub-model to correctly represent the data set as a whole in sampling. Multi-class classification models may also use the grouping to improve classification accuracy by weighing group data samples according to the estimated latent dimensionality of the group.

Abstract: In one example in accordance with the present disclosure, an additive manufacturing stage is described. The additive manufacturing stage includes a bed to define a volume where a three-dimensional object is to be formed. The additive manufacturing stage also includes an air-permeable platform on which build material is deposited. A vacuum system draws air resident in the build material down through the air-permeable platform.

Abstract: A rotary actuator includes a housing having a first end and a second end spaced from the first end along an axis. The housing defines a cavity extending circumferentially about the axis. An output shaft is arranged coaxially with the axis. The output shaft extends outwardly from the cavity through the first end. A drive system is disposed in the cavity and axially spaced from the first end. A gearbox is disposed in the cavity between the output shaft and the drive system. The gearbox is coupled to the drive system and the output shaft. A rotational controller is disposed in the cavity between the drive system and the second end. The rotational controller is configured to actuate the drive system to adjust an angular position of the output shaft.

Abstract: A surgical instrument includes an end effector and a handle assembly. The end effector is configured to operate at a first energy level and at a second energy level. The end effector is further configured to transition between an open position and a closed position. The end effector is configured to grasp tissue in the closed position. The handle assembly includes a body, a trigger, and an activation element. The trigger is configured to pivot in a first direction relative to the body to actuate the end effector from the open position to the closed position. The activation element is configured to activate the end effector at either the first energy level or the second energy level. The trigger is configured to either activate the activation element or determine whether the end effector operates at the first energy level or the second energy level.

Abstract: An embodiment of the invention provides a process performed by a media streaming network, wherein the network is operable to stream media data from transmission modules to viewing interfaces and wherein the process comprises: requesting that the media server instantiate a media streaming service from which media can be streamed to one or more viewer interfaces; receiving input connection data from the media server, the input connection data carrying information to allow a transmission module to provide media to be streamed from the media streaming service; and transmitting to a transmission module input connection data to allow the transmission module to connect to the media service instantiated, wherein a transmission module is a module is operable to transmit media to the network to provide the transmission module.

Abstract: A method and system that provides for execution of a first calibration sequence, such as upon initialization of a system, to establish an operation value, which utilizes an algorithm intended to be exhaustive, and executing a second calibration sequence from time to time, to measure drift in the parameter, and to update the operation value in response to the measured drift. The second calibration sequence utilizes less resources of the communication channel than does the first calibration sequence. In one embodiment, the first calibration sequence for measurement and convergence on the operation value utilizes long calibration patterns, such as codes that are greater than 30 bytes, or pseudorandom bit sequences having lengths of 2N?1 bits, where N is equal to or greater than 7, while the second calibration sequence utilizes short calibration patterns, such as fixed codes less than 16 bytes, and for example as short as 2 bytes long.

Abstract: A computer-implemented method of providing proof that a blockchain transaction exists on a blockchain, wherein the method is performed by a Merkle proof entity configured to store a set of transaction identifiers of respective blockchain transactions but not to publish new blockchain blocks to the blockchain network, and wherein the method comprises: obtaining a target transaction identifier of a target blockchain transaction, wherein the target transaction identifier forms part of the stored set of transaction identifiers; obtaining a target Merkle proof for the target blockchain transaction, wherein a corresponding target Merkle root is contained within a blockheader of the blockchain; and outputting the target Merkle proof for use by the requesting party as proof that the target blockchain transaction exists on the blockchain.

Abstract: An actuator includes a housing defining a cavity. The actuator further includes a hub disposed in the cavity. The actuator further includes a controller disposed in the cavity and supported by the hub. The actuator further includes potting compound surrounding the controller within the cavity.

Abstract: Methods and apparatus to communicate via a welding arc are disclosed. An example welding-type power supply includes a power converter, a weld monitor, and an arc modulator. The power converter outputs welding power to sustain a welding-type arc at a welding-type torch. The weld monitor monitors one or more aspects of a weld performed using the welding-type arc and the welding-type torch, and selects an audio message based on the one or more aspects. The arc modulator configured to modify the welding-type arc to output the selected audio message as a plasma speaker.

Abstract: A cable includes a wiring assembly with a knuckle and wires bundled together. The cable also includes a connector assembly with a connector having connections for the wires, where the connections are arranged along a longitudinal axis. In some embodiments, the connector assembly captures an end of the wiring assembly, and the knuckle of the wiring assembly is pivotally connected to the connector assembly. In some embodiments, the cable includes circuitry configured to authenticate the cable to a device connected to the cable by the connector and/or to authenticate the device connected to the cable. A control system includes control elements and/or subsystems coupled with a backplane adjacent to one another and cables configured to connect to the control elements and/or subsystems. Wiring assemblies of the cables can articulate to be parallel to each respective connector. Further, each cable can authenticate the cables and/or the control elements or subsystems.

Abstract: A drive mechanism for actuating a control surface of a vehicle that moves through a fluid medium. The mechanism directly translates the rotational motion provided by an input drive to a control surface that is used to direct the vehicle. The mechanism provides both weight and space savings as well as limits, if not eliminates, backlash. The angled drive mechanism may be particularly suited for use in applications such as UAV/UUV, munitions, and other relatively small platforms.

Abstract: A risk management system (RMS) device includes a RMS database and a RMS processor. The RMS processor includes a prescriber module to receive a request to enroll a patient in a RMS program of a therapeutic agent associated with multiple indications. The request includes a specification of at least one indication, and a confirmation of a diagnostic test conducted on the patient. The RMS processor also includes a patient module configured to generate a patient profile. The RMS processor also includes a database module configured to store the patient profile in the RMS database. The RMS processor also includes an authorization module configured to generate an authorization code indicating whether the patient is authorized to receive the therapeutic agent. The RMS processor also includes a communication module configured to transmit the authorization code to a pharmacy or a prescriber.

Abstract: Systems, apparatuses, and methods related to acceleration circuitry for posit operations are described. A first operand formatted in a universal number or posit format can be received by a first buffer resident on acceleration circuitry. A second operand formatted in a universal number or posit format can be received by a second buffer resident on the acceleration circuitry. An arithmetic operation, a logical operation, or both can be performed using processing circuitry resident on the acceleration circuitry using the first operand and the second operand. A result of the arithmetic operation, the logical operation, or both can be received by a third buffer resident on the acceleration circuitry.

Abstract: An adjustable packer apparatus for adjusting a clearance space between at least two support members. The adjustable packer apparatus having at least one first and one second planar member and adjustment means. The planar members are configured and spaced from each other and each include an one aperture there through whereby one planar member is movably attachable by the adjustment means through alignment of the at least one aperture of one planar member to the other planar member. The adjustment means includes at least one bolt attached to the second planar member. The first planar member has a threaded member protruding therefrom, wherein the bolt is threadingly engaged with the threaded member. The second planar member is attachable to one of the two support members which provides a stiffer or less flexible support than that provided by or for the first planar member. A method of installation is also disclosed.

Abstract: A device may be configured to detect a glare condition and may comprise a photo sensing circuit and a visible light sensing circuit. The photo sensing circuit may be configured to periodically generate an illuminance signal that indicates an illuminance value. The visible light sensing circuit may be configured to periodically record images of the space at an exposure time. The device may receive an illuminance signal from the photo sensing circuit and determine a present illuminance based on the illuminance signal. The device may adjust the frequency at which the visible light sensing circuit records images based on the present illuminance. The exposure time may be determined based on the present illuminance and a glare condition type. An image recorded at a respective exposure time may wash out pixels above a certain illuminance value. The device may detect a glare condition at the location of washed out pixels.

Abstract: A femoral trialling kit and method for assessing acetabular cup orientation during a left hip joint surgical procedure and a right hip joint surgical procedure are described. The kit includes a trial femoral head (104, 414, 514, 614, 814) having an inner wall defining a cavity extending along a head axis and a visual alignment guide on an outer surface of the trial femoral head and a trial femoral neck (126, 412, 512, 612, 812) having a taper at a free end, the taper being receivable within the cavity. One of the taper and the inner wall has a first anti-rotation feature (684, 698) and a second anti-rotation feature (686, 700), the first anti-rotation feature and the second anti-rotation feature being inclined, and the other of the taper and the inner wall has a third anti-rotation feature (702).

Abstract: A method of controlling resynchronization of a source database and a target database may comprise detecting that a connection between the source database and the target database has been restored. Based on the detecting, the method may also comprise identifying a first edit flag for a first row in a first table on the source database. Based on the identifying, the method may also comprise sending the first row from the source database to the target database. Based on the sending, the method may also comprise clearing the first edit flag for the first row.