Abstract: Disclosed are methods of treating diseases or disorders associated with cellular senescence as well as methods of inducing ferroptosis in senescent cells. The methods include administering a compound that induces ferroptosis.

Abstract: Methods are provided that relate to the discovery that dihomo-gamma linolenic acid (DGLA) is a potent senolytic agent. Accordingly, in certain embodiments, methods of selectively killing one or more senescent cells in a subject in need thereof are provided wherein the method(s) involves administering to the subject an effective amount of DGLA.

Abstract: An article of manufacture for providing a golf chipping and pitching training tool is disclosed. The article includes a circular golf landing mat, a center cut out for indicating a golf cup, a set of concentric circles centered about the center cut out, and a horizontal and vertical line across the golf landing mat dividing the golf landing mat into 4 quadrants.

Abstract: Various biological markers that function as indicators of the level of senescent cells in an organism are provided. In certain embodiments, the markers described herein (e.g., eicosanoids) can provide effective indicators of the presence and/or quantity of senescent cells in a subject (e.g., in a human or non-human mammal) and methods of identifying elevated levels of senescent cells in a mammal, and methods for determining the efficacy of senolytic agents, are provided.

Abstract: Methods and systems described herein provide or use a wall structure for a hydrocarbon storage vessel. The wall structure includes an inner layer comprising a first rubber compound, a center layer comprising a fabric having a barrier layer applied to each side, and an outer layer comprising a second rubber compound.

Abstract: A radiation upset detector is provided. The radiation upset detector includes at least one radiation sensitive memory initialized with at least one respective known-signature word; and at least one radiation hardened logic circuitry communicatively coupled to the at radiation sensitive memory to check the known-signature word at at least a kHz rate to detects errors. Responsive to detecting an error in the known-signature word in the radiation sensitive memory, the radiation hardened logic circuitry sends an action command. At least one of: a memory size of the memory; a number of circuits in the logic circuitry; a clock rate for the checking the known-signature word; and at least one corruption threshold is selected based on system reliability requirements of the protected system including at least one of: an overall operational reliability requirement of the protected system; a probability of detection success; false alarm rates; and a required speed of detection.

Abstract: A system for controlling and containing wildfires comprises a transport unit that is configured to transport the system to a site of a wildfire. At least one fluid-spraying apparatus is configured to spray and blow fluid at the wildfire for control and containment thereof. At least one linkage device is configured to movingly link the transport unit to a corresponding fluid-spraying apparatus. The transport unit is configured to control operation of the transport unit, linkage device, and fluid-spraying apparatus. The linkage device is configured to move with respect to the transport unit and the fluid-spraying apparatus is configured to move with respect to the linkage device such that the fluid can be sprayed multi-directionally for control and containment of the wildfire.

Abstract: Methods and systems described herein provide or use a wall structure for a hydrocarbon storage vessel. The wall structure includes an inner layer that includes a first rubber compound. A center layer includes a polymer film. An outer layer includes a second rubber compound.

Abstract: A radiation upset detector is provided. The radiation upset detector includes at least one radiation sensitive memory initialized with at least one respective known-signature word; and at least one radiation hardened logic circuitry communicatively coupled to the at radiation sensitive memory to check the known-signature word at at least a kHz rate to detects errors. Responsive to detecting an error in the known-signature word in the radiation sensitive memory, the radiation hardened logic circuitry sends an action command. At least one of: a memory size of the memory; a number of circuits in the logic circuitry; a clock rate for the checking the known-signature word; and at least one corruption threshold is selected based on system reliability requirements of the protected system including at least one of: an overall operational reliability requirement of the protected system; a probability of detection success; false alarm rates; and a required speed of detection.

Abstract: A system for controlling and containing wildfires comprises a transport unit that is configured to transport the system to a site of a wildfire. At least one fluid-spraying apparatus is configured to spray and blow fluid at the wildfire for control and containment thereof. At least one linkage device is configured to movingly link the transport unit to a corresponding fluid-spraying apparatus. The transport unit is configured to control operation of the transport unit, linkage device, and fluid-spraying apparatus. The linkage device is configured to move with respect to the transport unit and the fluid-spraying apparatus is configured to move with respect to the linkage device such that the fluid can be sprayed multi-directionally for control and containment of the wildfire.

Abstract: Methods and systems described herein provide or use a wall structure for a hydrocarbon storage vessel. The wall structure includes an inner layer that includes a first rubber compound. A center layer includes a polymer film. An outer layer includes a second rubber compound.

Abstract: Methods and systems described herein provide or use a wall structure for a hydrocarbon storage vessel. The wall structure includes an inner layer comprising a first rubber compound, a center layer comprising a fabric having a barrier layer applied to each side, and an outer layer comprising a second rubber compound.

Abstract: A vehicle safety seat with mechanical shock indication includes a safety seat body defining a seat region for a child during vehicle travel and a mechanical shock indicator assembly mounted to the safety seat body for indicating that the child vehicle safety seat has suffered a mechanical shock of a least a predetermined magnitude.

Abstract: A method may include storing rules associated with processing calls. Each of the rules may include a maximum number of calls per unit of time. The method may also include determining whether the maximum number of calls per unit of time associated with a first one of the rules is greater than a threshold. The method may further include allocating by a first node, when the maximum number of calls per unit of time is greater than the threshold, a number of calls per unit of time to the first node based on the number of calls satisfying the first rule that were received by the first node and a total number of calls satisfying the first rule that were received by all of the nodes.

Abstract: A method may include storing rules associated with processing calls. Each of the rules may include a maximum number of calls per unit of time. The method may also include determining whether the maximum number of calls per unit of time associated with a first one of the rules is greater than a threshold. The method may further include allocating by a first node, when the maximum number of calls per unit of time is greater than the threshold, a number of calls per unit of time to the first node based on the number of calls satisfying the first rule that were received by the first node and a total number of calls satisfying the first rule that were received by all of the nodes.

Abstract: A hydrostatic transmission mountable to a vehicle frame. The hydrostatic transmission is adapted to removeably receive an axle shaft. The hydrostatic transmission is also adapted to be mounted to at least one of two opposed side members of the vehicle frame. The opposed side members have openings through which the axel shaft passes. The vehicle may be a snow thrower.

Abstract: Disclosed is a vehicle comprising a transaxle and a bypass mechanism. The transaxle has a plurality of mounting holes for use in attaching the transaxle to the vehicle. Further, the transaxle has at least one mounting hole more than is used to attach the transaxle to the vehicle. The bypass mechanism comprises a bypass linkage. Finally, the bypass linkage is supported by the mounting hole.

Abstract: A hydrostatic transmission mountable to a vehicle frame. The hydrostatic transmission is adapted to removeably receive an axle shaft. The hydrostatic transmission is also adapted to be mounted to at least one of two opposed side members of the vehicle frame. The opposed side members have openings through which the axel shaft passes. The vehicle may be a snow thrower.