Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: Transdermal compositions including chitosan, glycated chitosan, or a combination thereof are provided for use in treatment methods wherein the compositions are externally applied for relieving pain and inflammation, treating erectile dysfunction, treating acne, causing hair growth, and for veterinary treatment of animals for relieving pain and inflammation.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: An ophthalmic implant having a body for positioning in a recess created in the sclera, feet for positioning in the anterior chamber, and a neck between the body and the feet for positioning in a scleral opening created between the scleral recess and the anterior chamber. The implant feet extend beyond the implant body and have a curvature approximating the curvature of the anterior chamber. The implant has drainage passageways for draining ocular fluid from the anterior chamber. The passageways are formed in outer surfaces or through the interior of the implant. Interior passageways are formed in surfaces of layers of the implant or by voids in inner layers of the implant. Related methods include creating undercuts that receive outer portions of the implant body and creating a scleral opening that is longer than the implant neck.

Abstract: A soldered feed-through device that is inserted into a bulkhead opening has one or more sets of laterally protruding and symmetrically distributed teeth that cut through the bulkhead material as the feed-through is inserted into the bulkhead opening. The teeth automatically center the feed-through device within the bulkhead opening and resist tilting of the feed-through and its through-hole conductor so that application of solder to the area between the feed-through and the inner periphery of the opening produces a solder joint having uniform radial thickness of preferably about 0.14 mm (0.0055 in.).

Abstract: A press-fit feed-through device has one or more sets of laterally protruding and symmetrically distributed teeth that are laterally aligned and cut through the material of a bulkhead as the feed-through is inserted into a bulkhead opening. Lateral grooves disposed immediately inboard of each set of teeth receive the bulkhead material cut by the respective set of teeth. In feed-through devices having more than one set of teeth, the additional sets of teeth are located successively outboard of, and in axial alignment with, the first set of teeth, and cut successively deeper into the bulkhead as the feed-through is inserted into the opening.

Abstract: An ophthalmic implant having a body for positioning in a recess created in the sclera, feet for positioning in the anterior chamber, and a neck between the body and the feet for positioning in a scleral opening created between the scleral recess and the anterior chamber. The implant feet extend beyond the implant body and have a curvature approximating the curvature of the anterior chamber. The implant has drainage passageways for draining ocular fluid from the anterior chamber. The passageways are formed in outer surfaces or through the interior of the implant. Interior passageways are formed in surfaces of layers of the implant or by voids in inner layers of the implant. Related methods include creating undercuts that receive outer portions of the implant body and creating a scleral opening that is longer than the implant neck.

Abstract: A press-fit feed-through device has one or more sets of laterally protruding and symmetrically distributed teeth that are laterally aligned and cut through the material of a bulkhead as the feed-through is inserted into a bulkhead opening. Lateral grooves disposed immediately inboard of each set of teeth receive the bulkhead material cut by the respective set of teeth. In feed-through devices having more than one set of teeth, the additional sets of teeth are located successively outboard of, and in axial alignment with, the first set of teeth, and cut successively deeper into the bulkhead as the feed-through is inserted into the opening.

Abstract: A soldered feed-through device that is inserted into a bulkhead opening has one or more sets of laterally protruding and symmetrically distributed teeth that cut through the bulkhead material as the feed-through is inserted into the bulkhead opening. The teeth automatically center the feed-through device within the bulkhead opening and resist tilting of the feed-through and its through-hole conductor so that application of solder to the area between the feed-through and the inner periphery of the opening produces a solder joint having uniform radial thickness of preferably about 0.14 mm (0.0055 in.).

Abstract: Preparations containing glycated chitosan in a physiologically compatible carrier are described. Viscoelastic preparations comprise 1.0-12.0 percent by weight of glycated chitosan in an aqueous solution while lower viscosity solutions possess 0.1-0.5 percent by weight glycated chitosan. The otherwise free amino groups of the chitosan polymer are preferably 30-90% glycated and possess an average molecular weight of between 100,000 and 2,000,000 Daltons, and, most preferably between 100,000 and 1,000,000 Daltons.

Abstract: An apparatus for the delivery of laser light in a therapeutic environment including: a console; an optical waveguide wherein a first end of the waveguide is configured to expose a biological tissue to energy transmitted through the waveguide; a plurality of laser diodes housed within the console such that the light emitted by each of the diodes will illuminate a second end of the optical wave guide; and a power supply for providing electrical power to each laser diode. Preferably each laser diode is configured to produce a unique wavelength of light. The power supply provides an independently controllable output for each laser such that the exposure, both in terms of intensity and duration, to each wavelength of light may be controlled independently of the exposure to each of the other wavelengths of light.

Abstract: The present invention combines physical and immunologic therapies for the treatment of neoplasms by conditioning a targeted neoplasm with an immunoadjuvant (also called immunomodulator or immunopotentiator) and then physically destroying the conditioned neoplasm. A number of physical therapies can be used to achieve the physical destruction of the conditioned tumor mass.

Abstract: An improved method of manufacture for wire feed-through devices, wherein a pre-formed tubular seal having a central axial opening for accommodating the wire insulates the wire from the ferrule and provides a tight environmental seal between the ends of the ferrule. The seal is radially compressed and then inserted, either by itself or with the wire, into the central opening of the ferrule so that the seal is maintained in compression between the wire and an inside diameter of the ferrule. In devices where one end of the ferrule opening is enlarged to accommodate one or more filter elements, the seal is positioned in the narrow portion of the ferrule opening, and additionally serves to maintain an inherent concentricity of the wire within the ferrule during installation and attachment of the filter elements, and injection or insertion of encapsulant material into the enlarged portion of the ferrule opening.

Abstract: An apparatus for the delivery of laser light in a therapeutic environment including: a console; an optical waveguide wherein a first end of the waveguide is conffigured to expose a biological tissue to energy transmitted through the waveguide; a plurality of laser diodes housed within the console such that the light emitted by each of the diodes will illuminate a second end of the optical wave guide; and a power supply for providing electrical power to each laser diode. Preferably each laser diode is configured to produce a unique wavelength of light. The power supply provides an independently controllable output for each laser such that the exposure, both in terms of intensity and duration, to each wavelength of light may be controlled independently of the exposure to each of the other wavelengths of light.

Abstract: The present invention combines physical and immunologic therapies for the treatment of neoplasms by conditioning a targeted neoplasm with an immunoadjuvant (also called immuno-modulator or immunopotentiator) and then physically destroying the conditioned neoplasm. A number of physical therapies can be used to achieve the physical destruction of the conditioned tumor mass.