Patents by Inventor A. E. P. Adang

A. E. P. Adang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of post-menopausal complaints in breast cancer patients comprising tibolone and a serm
    Publication number: 20050222100
    Abstract: The subject invention provides a use of tibolone and a SERM for the manufacture of a medicine for the treatment of an estrogen-deficiency related complaint and for the prevention of a recurrence of breast cancer in females suffering from, or at risk for breast cancer that exhibit the estrogen-deficiency related complaint.
    Type: Application
    Filed: May 20, 2003
    Publication date: October 6, 2005
    Inventors: H. J. Kloosterboer, A. E. P. Adang
  • Bicyclic heteroamatic compounds useful as LH agonists
    Patent number: 6569863
    Abstract: The invention relates to a bicyclic heteroaromatic derivative compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is NR5R6, OR5, SR5 or R7; R5 and R6 are independently selected from H, (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, alkyl(1-8C)carbonyl, (6-14C)arylcarbonyl, (6-14C)aryl or (4-13C)heteroaryl, or R5 and R6 together are joined in a (2-7C)heterocloalkyl ring; R7 is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl, R2 is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)alkylthio, (1-8C)(di)alkylamino, (1-8C)alkoxy, (2-8C)alkenyl, or (2-8C)alkynyl; R3 is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)(di)al
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: May 27, 2003
    Assignee: Akzo Nobel NV
    Inventors: G. G. Gerritsma, N. C. R. Van Straten, A. E. P. Adang
  • Thrombin inhibitors
    Patent number: 6432921
    Abstract: The invention relates to non-slow-binding thrombin inhibitors of the formula: A—B—C-Lys-D wherein A is H, 2-hydroxy-3-cyclohexylpropionyl-, R1, R1—O—CO—, R1—CO—, R1—SO2—, —(CHR2)nCOOR3, or an N-protecting group, wherein R1 is selected from —(1-6C)alkylene-COOH, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl; and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy, or halogen; R2 is H or has the same meaning as R1, R3 is selected from H, (1-12C)alkyl, (2-12C)alkenyl, (6-14C)aryl, (7-15C)aralkyl and (8-16C)aralkenyl, the aryl group of which may be substituted with (1-6C)alkyl, (2-12C)alkoxy, hydroxy or halogen; n is an integer of 1 to 3; B is a bond, L-Asp or an ester derivative thereof, Leu, norLeu, —N(benzyl)-CH2—CO—, —N(2-indane)-CH2—CO—, D-1-Piq, D-3-Piq, D-Tiq, Atc or a D-amino acid having a hydrophobic aromatic side chain; C is Azt, Pro, Pec, no
    Type: Grant
    Filed: May 3, 1998
    Date of Patent: August 13, 2002
    Assignee: Akzo Nobel N.V.
    Inventors: A. E. P. Adang, C. A. A. van Boeckel, J. A. M. Peters, P. D. J. Grootenhuis