Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim.

Abstract: Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim.

Abstract: Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim.

Abstract: An automatic hand brake system for a railcar including a release mechanism operatively connected between an actuator and the spool gear that is turned by hand to set the hand brake. The actuator is operatively connected to a pressured fluid system. When a threshold pressure is reached the actuator operates the release mechanism to release the spool gear so that the brakes are released. When there is a pressure drop, an automatic reset apparatus resets the release mechanism so that the hand brake can set. In one aspect, the pressurized fluid system such is an air brake system. In another aspect, the pressurized fluid system is oil or hydraulic system or a combination of air and oil. An apparatus can be employed to permit release of the hand brake if desired.

Abstract: A publishing system and method for distributing electronic and paper documents for multiple financial service products is disclosed. The system includes a memory device configured to store policy information for the multiple financial service products associated with each of a plurality of clients to store communication settings for each of the multiple financial service products, the communication settings including contact information and notification preferences, and to store document templates. The system includes a processor configured to process a request for generating notification/alert documents, to generate notification/alert documents by modifying the document templates based on the policy information and communication settings and to store the notification/alert documents in the memory device, and to determine whether the notification/alert documents were not received or received in error.

Abstract: Systems and methods for an interactive graphical user interface for depicting the status of a claim are provided. The system includes a database for storing claim data and a server in communication with the database. The stored claim data includes a claim workflow associated the claim. The workflow defines the processing steps associated with processing the claim. The server receives a user request to check the status of the claim. The server determines status data of the claim based on stored claim data and outputs the status data to a graphical user interface for depicting a graphical representation of the status data. The graphical representation includes a timeline corresponding to the workflow of the claim and a progress bar indicative of the status of the claim.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: A surgical instrument includes a clamp having a handle with a pair of substantially parallel prongs or tines extending from the handle, all formed as a unitary body or article of manufacture. The handle and prongs define a channel to receive a knife. The knife includes a handle, a scalpel, and an extension arm coupling the scalpel to the handle. The clamp defines a minor image about a central axis. In this way, the surgeon need not concern himself with whether the knife is oriented properly within the channel. Also, the extension arm of the knife includes graduations to assist the surgeon in predetermining precisely the distance of cut in using the instrument. The upper prong of the clamp includes a downwardly extending capture pad having a bottom surface substantially parallel to the inner surface of the lower prong.

Abstract: A system and method are disclosed herein for determining an insurance policy adjustment based on information indicative of life events. The system includes a server, a database, and a business logic computer. The database receives from a user an indication of an occurrence of a life event experienced by the user. The database stores insurance parameter data associated with the user. The business logic computer communicates with the server and database. The business logic computer can receive the user indication via the server and poses questions to send to the user based on the indicated life event. The business logic computer can send the questions to the user via the server. After receiving the user's answers to the questions, the business logic computer determines an insurance policy adjustment based on the answers and the indicated life event.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: This invention is a temperature-based smart insole capable of continuously or intermittently measuring the foot temperature of the patient at one or more locations of the foot while the insole is worn. The device provides feedback to the patient alerting the individual of risk based on his/her plantar temperatures. Benefits of this device include: its ability to free the patient from the clinical setting and increase patient's confidence to be mobile, thus enhancing circulation while at the same time allowing the patient to self-monitor their feet.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: This invention is a temperature-based smart insole capable of continuously or intermittently measuring the foot temperature of the patient at one or more locations of the foot while the insole is worn. The device provides feedback to the patient alerting the individual of risk based on his/her plantar temperatures. Benefits of this device include: its ability to free the patient from the clinical setting and increase patient's confidence to be mobile, thus enhancing circulation while at the same time allowing the patient to self-monitor their feet.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.

Abstract: An insulated barrier comprising first and second gas impermeable rigid walls, preferably of a composite of an organic substrate, such as plastic, coated with an inorganic matrix, such as a metal oxide, adjoining surfaces between the first and second walls in order to create an entirely closed and substantially hermetically sealed structure, a core material between the walls comprising an open-cell structure and an optional vacuum breach sensor within the insulated barrier by which the presence of atmospheric oxygen may be detected. Also disclosed is a process by which insulated barriers may be manufactured in accordance with the present invention.

Abstract: Organic, small pore area materials (“SPMs”) are provided comprising open cell foams in unlimited sizes and shapes. These SPMs exhibit minimal shrinkage and cracking. Processes for preparing SPMs are also provided that do not require supercritical extraction. These processes comprise sol-gel polymerization of a hydroxylated aromatic in the presence of at least one suitable electrophilic linking agent and at least one suitable solvent capable of strengthening the sol-gel. Also disclosed are the carbonized derivatives of the organic SPMs.