Abstract: The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

Abstract: The present invention provides systems and methods for secure transaction management and electronic rights protection. Electronic appliances such as computers equipped in accordance with the present invention help to ensure that information is accessed and used only in authorized ways, and maintain the integrity, availability, and/or confidentiality of the information. Such electronic appliances provide a distributed virtual distribution environment (VDE) that may enforce a secure chain of handling and control, for example, to control and/or meter or otherwise monitor use of electronically stored or disseminated information. Such a virtual distribution environment may be used to protect rights of various participants in electronic commerce and other electronic or electronic-facilitated transactions. Distributed and other operating systems, environments and architectures, such as, for example, those using tamper-resistant hardware-based processors, may establish security at each node.

Abstract: The invention provides a combination comprising an ancillary compound (e.g.

Abstract: The present invention is directed to a mutant thermostable ligase having substantially higher fidelity than either T4 ligase or Thermus thermophilus ligase. The ligase of the present invention is a mutant of a wild-type thermostable ligase having a histidine adjacent a KXDG motif, where the mutant thermostable ligase has a mutation in its amino sequence where the histidine adjacent the KXDG motif in the wild-type thermostable ligase is replaced with an arginine, and wherein X is any amino acid. The DNA molecule encoding this enzyme as well as expression systems and host cells containing it are also disclosed. The thermostable ligase of the present invention is useful in carrying out a ligase detection reaction process and a ligase chain reaction process.

Abstract: An exposed die overmolded flip chip package includes a substrate. A die is flip chip mounted to an upper surface of the substrate. The package further includes a mold cap filling a apace between an active surface of the die and the upper surface of the substrate. The mold cap includes a principal surface, sidewalls extending from the upper surface of the substrate to the principal surfaces, an annular surface coplanar with the inactive surface of the die and extending outward from a peripheral edge of the inactive surface of the die, and protruding surfaces extending between the principal surface and the annular surface. The mold cap does not cover the inactive surface of the die such that heat transfer from the die to the ambient environment is maximized and the package thickness is minimized.

Abstract: An exhaust system, and a catalyzed substrate for use in an exhaust system, is disclosed. The exhaust system comprises a lean NOx trap and the catalyzed substrate. The catalyzed substrate has a first zone, having a platinum group metal loaded on a support, and a second zone, having copper or iron loaded on a zeolite. The first zone or second zone additionally comprises a base metal oxide or a base metal loaded on an inorganic oxide. Also provided are methods for treating an exhaust gas from an internal combustion engine using the exhaust system. The exhaust system is capable of storing NH3 generated in rich purging, reacting the NH3 with slip NOx, controlling H2S released from NOx trap desulfation, and oxidizing slip hydrocarbons and carbon monoxide. When the catalyzed substrate is a filter substrate, it is also capable of removing soot from exhaust system.

Abstract: A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSAID may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.

Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.

Abstract: An access point receives a notification (or advertisement) from a device, which lacks a service. The access point adds the service to the notification, and forwards the notification to other devices on the network. Upon receiving from a control point a request to use the added service, the access point provides the service on behalf of the device.

Abstract: A rush hour modeling system that is configured for modifying existing travel time/distance data to reflect special traffic conditions, such as rush hour traffic conditions. The system is configured to receive information defining one or more time windows, geographic areas, and road segments in which special traffic conditions occur. The system is also configured to receive travel rules that reflect the special traffic conditions. The travel rules are used to modify a travel time/distance matrix to reflect the effect of the special traffic conditions on “normal” travel times and distances. Existing routing and scheduling systems can then use the modified travel matrix to plan and schedule routes for delivery vehicles more accurately. Additionally, the modified travel matrix can be used to model traffic conditions through a particular geographic area or on a particular road segment.

Abstract: Some examples provide systems, methods, apparatus, and computer program products for providing a market platform. The market platform may operate to inform buyers and suppliers, to allow buyers and suppliers to select products and contracting parameters to meet their needs, to allow buyers and suppliers to commit to supply agreements, and to enforce those supply agreements. These examples may provide such an integrated system by receiving buyer spend data, receiving contract offers from one or more suppliers based on the spend data, allowing the buyer to select one or more of the contract offers, and monitoring spend data to ensure compliance with the selected contract offer. The system may include dynamic pricing models, altering the price of the purchased products based on compliance with the selected contract offer. The system may also allow for various contracting models for managing the pricing of products based on the contractual terms agreed to by the buyer and supplier.

Abstract: News feed stories are ranked so that new stories appear above previously viewed stories for users of a social networking system. Top news stories are selected by the social networking system based on a ranking algorithm that incorporates an analysis of affinities for interests, users, and entities in the social networking system based on user interactions. Other new stories are provided after the top new stories in a chronological order. For each user of the social networking system, a view state is recorded that includes the order of news feed stories provided to users. Based on the view state and received user input, the social networking system may determine whether to provide new news feed stories to a viewing user.

Abstract: An endless electrophotographic member, such as a developer roller, which indicates an improved resistance to nip banding. The improvement to nip banding may be provided by the use of an organic salt within a roller surface region. The roller may provide, at a nip location, a resistive surface layer having an electrical resistance that avoids the development of nip banding and relatively dark regions on printed media.

Abstract: A method of winding a glass ribbon (10), including: winding an interleaving material (20) and the glass ribbon together to produce a roll (40); and tensioning the interleaving material so as to control a roll inter-layer pressure. By controlling the roll inter-layer pressure, the roll can be formed with straight side walls. The tension in the interleaving material can be controlled so as to be greater than 0 and ?0.25 pounds per linear inch of width of interleaving material. Also, there is provided an apparatus for winding glass ribbon together with interleaving material into a roll. The apparatus includes: an interleaving material supply path; a glass ribbon supply path; a roll winding mechanism (46); and a means (26) for applying tension to interleaving material traveling along the interleaving material supply path, as the interleaving material is wound into roll (40), so as to produce a pressure between the layers of the roll.

Abstract: Methods and kits for treating a fibrous substrate prior to forming an image thereon are provided. The method can include positioning a treatment sheet adjacent to the fibrous substrate, transferring a salt (e.g., calcium chloride, magnesium chloride, or a mixture thereof) from the treatment sheet to the fibrous substrate using a wetting solution (e.g., an aqueous solution, such as water) to carry the salt from the treatment sheet into the fibrous substrate, and drying the fibrous substrate such that the salt remains in the substrate. For example, the transfer of the salt from the treatment sheet into the fibrous substrate can be accomplished via pressing the backside of the treatment sheet such that the wetting solution flows from the treatment sheet into the fibrous substrate while carrying the salt.

Abstract: Some examples provide systems, methods, apparatus, and computer program products for providing a market platform. The market platform may operate to inform buyers and suppliers, to allow buyers and suppliers to select products and contracting parameters to meet their needs, to allow buyers and suppliers to commit to supply agreements, and to enforce those supply agreements. The market platform may be further configured to capture data related to transactions performed by buyers and suppliers that use the market platform system to perform said transactions. This data may be utilized to generate a set of analytics to assist both buyers and suppliers with making informed decisions about their transactions. The market platform may identify correlations between buyer characteristics and product selections, to assist the buyer with selecting products that are generally appropriate for their particular characteristics and/or needs.

Abstract: Sterilization wraps have a first side colored at least a first color and an opposing second side colored at least a second color that is different than the first color. These sterilization wraps are then paired such that each of the pairs of sterilization wraps has the aforementioned first sides of the sterilization wraps that comprise the pair of sterilization wraps facing one another. By one approach these pairs of sterilization wraps are un-bonded and hence are not physically connected to one another. By another approach the sterilization wraps that comprise a given pair can be coupled to one another (for example, by an intermingling of the materials that comprise the two sterilization wraps). A plurality of such pairs of sterilization wraps can then be placed in a suitable container to facilitate handling, storage, and shipment.

Abstract: A method for manufacturing a semiconductor component that includes the use of multiple layers of photoresist. A first layer of electrically conductive material is formed over a substrate and a first layer of photoresist is formed over the first layer of electrically conductive material. A portion of the first layer of photoresist is removed leaving photoresist having sidewalls separated by a gap. A second layer of electrically conductive material having first and second sidewalls is formed in the gap. A second layer of photoresist is formed over the first layer of photoresist and over the second layer of electrically conductive material. Portions of the second layer of photoresist and the first layer of photoresist are removed to uncover the first and second edges of the second layer of electrically conductive material. A protective structure is formed over the first and second edges of the second electrically conductive material.

Abstract: A parallel tapped magnetic pickup for an electrical stringed musical instrument is provided. The parallel tapped magnetic pickup comprises a coil formed with at least two parallel connected wound wires. A guitar in combination with the parallel tapped pickup is additionally provided.

Abstract: Some examples provide systems, methods, apparatus, and computer program products for providing a market platform. The market platform may operate to inform buyers and suppliers, to allow buyers and suppliers to select products and contracting parameters to meet their needs, to allow buyers and suppliers to commit to supply agreements, and to enforce those supply agreements. These examples may provide such an integrated system by receiving buyer spend data, receiving contract offers from one or more suppliers based on the spend data, allowing the buyer to select one or more of the contract offers, and monitoring spend data to ensure compliance with the selected contract offer. The system may include dynamic pricing models, altering the price of the purchased products based on compliance with the selected contract offer. The system may also allow for various contracting models for managing the pricing of products based on the contractual terms agreed to by the buyer and supplier.