Abstract: The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.

Abstract: A toy projectile launcher for launching projectiles, e.g, toy foam darts, from a hopper. One or more agitating members inside the hopper to enable the projectiles to drop into a firing chamber under the hopper. A hopper cover has a collapsible ceiling with nested members and a ceiling plate to maintain the projectiles toward the bottom of the hopper. A catch coupled to the ceiling plate engages an opening in a hopper wall to prevent the ceiling from collapsing when the hopper cover is closed. Where there are multiple vertically spaced-apart openings in the hopper wall, the catch may disengage from a first opening, and then engage a lower, second opening in the hopper wall, as the number of projectiles in the hopper drops and the ceiling plate descends in the hopper. A rotating track and a push rod advance projectiles from the firing chamber to flywheels for launch.

Abstract: A glovebox assembly includes a support substrate, a glovebox rotationally displaceable with respect to the support substrate, a downstop carried on the support substrate and an interlock feature carried on the support substrate. The downstop includes a stalk and a head. The interlock feature overlaps the stalk adjacent the head.

Abstract: The present invention provides an aqueous electrolyte for use in rechargeable zinc-halide storage batteries that possesses improved stability and durability and improves zinc-halide battery performance. One aspect of the present invention provides an electrolyte for use in a secondary zinc bromine electrochemical cell comprising from about 30 wt % to about 40 wt % of ZnBr2 by weight of the electrolyte; from about 5 wt % to about 15 wt % of KBr; from about 5 wt % to about 15 wt % of KCl; and one or more quaternary ammonium agents, wherein the electrolyte comprises from about 0.5 wt % to about 10 wt % of the one or more quaternary ammonium agents.

Abstract: Provided is a method for a robotic device to autonomously overcome obstructions hindering the operational capacity of the robotic device. When a robotic device encounters an obstruction, the robotic device may enact one of a number of predetermined responses to overcome the obstruction without requiring the intervention of an outside entity to assist the robotic device with overcoming the obstruction.

Abstract: A toy projectile launcher capable of launching a substantially large number of projectiles, for example, toy foam darts. To increase the number of projectiles that can be launched between reloadings, the projectiles are housed in a hopper. The hopper may include a movable rear wall which facilitates the loading of a large number of projectiles into the hopper at one time. A portion of a side wall of the hopper may be agitated to loosen the projectiles within the hopper so that they will drop into a firing chamber of the launcher more easily. A cover for the hopper may have a collapsible ceiling to prevent the projectiles from becoming improperly oriented in the hopper as they are being loosened by the agitated portion of the side wall of the hopper. A rotating track and a push rod may cooperate to advance projectiles from a firing chamber of the launcher.

Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

Abstract: The present disclosure provides methods and systems for identifying and/or treating subjects having cancer, such as squamous cell carcinoma, who are more likely to respond to treatment with an ERK inhibitor.

Abstract: A rotary piston and cylinder device (1) comprising a rotor (2), a stator (4) and a rotatable shutter (3), the rotor comprising a piston (5) which extends from the rotor into a working chamber, the rotor and the stator together defining a working chamber, the shutter arranged to extend through the working chamber and forming a partition therein, and the shutter comprising a slot which allows passage of the piston therethrough, a bearing (20) which mounts the rotor relative to the stator, the rotor comprising a formation (12; 30) which extends substantially axially away from the chamber, and the formation being radially outward of the bearing and extending around the axis of rotation, and the formation comprising a surface which at least in part defines a space between the rotor and the stator, and at least part of that space and/or the formation overlaps in an axial direction with the bearing.

Abstract: A mount according to an example of the present disclosure includes a locating pin, a load pin, a fastener, the fastener configured to retain a component on at least one of the locating pin and the load pin, the fastener including a bolt, a mounting boss and a spring, the spring allowing the mounting boss to move with respect to the bolt, and wherein the bolt is held captive in the mounting boss with a captive feature. A gas turbine engine and a method of mounting a component are also disclosed.

Abstract: Systems, methods, and apparatus to weld by preheating welding wire and inductively heating a workpiece are disclosed. An example welding system includes: a welding current source configured to provide welding current to a welding circuit, the welding circuit comprising an electrode wire and a first contact tip of a welding torch; an electrode preheating circuit configured to provide preheating current through a first portion of the electrode wire via a second contact tip of the welding torch; and at least one induction heating coil configured to apply induction heat to a workpiece, the welding current source, the electrode preheating circuit, and the induction heating coil configured to perform a preheating operation and a welding operation on the workpiece.

Abstract: A method for collecting transaction history data and an associated terminal device. The method may include: collecting on-line, from a remote server (SV), first history data (DT) representative of at least one transaction associated with a user account (15); communicating contactlessly with a smart card (2), during which the terminal (T) recovers second history data (DH) stored locally in a memory (10) of the smart card, the second history data being representative of transactions processed by the smart card in association with the user account (15); and analyzing, during which the terminal (T) aggregates the first and second history data in order to obtain up-to-date history data. It is thus possible to generate transaction-following data from the up-to-date history data.

Abstract: A test point circuit includes a main RF signal path (e.g., transmission line, lumped-element network, etc.), a test point RF signal circuit, a test point structure having a center conductor and corresponding grounded sleeve and being configured for connecting to a test probe for monitoring the RF signal carried through the main RF signal path, and a switch between the main RF signal path and the test point RF signal circuit. In the open position of the switch, the signal in the main RF signal path is prevented from propagating to the center conductor of the test point structure. In the closed position of the switch, the RF signal can propagate from the main RF signal path to the center conductor of the test point structure. The test probe mated to the test point structure can then measure or monitor the RF signal carried through the main RF signal path.

Abstract: A system to present secure expandable advertisements using an API and cross-domain communication. A content publishing system that hosts a website can implement an expandable advertisement using IFRAMEs that are expanded upon receiving an API call from a third party rich media vendor that hosts the expandable advertisement when the content publishing system and the third party media vendor are of differing domains.

Abstract: A method for characterizing an electrocardiogram, including receiving a first unipolar signal from a first location of a heart and a second unipolar signal from a second location of the heart. The method further includes generating a bipolar signal from the first and second unipolar signals, and analyzing the bipolar signal to delineate a time period during which the first and second locations generate a bipolar complex. The method also includes analyzing the first unipolar signal within the time period to determine an activation time of the first location.

Abstract: An inspection apparatus is provided that comprises an optical target including a solid host material and a fluorescing material embedded in the solid host material. The solid host material has a predetermined phonon energy HOSTPE. The fluorescing material exhibits a select ground energy level and a target excitation (TE) energy level separated from the ground energy level by a first energy gap corresponding to a fluorescence emission wavelength of interest. The fluorescing material has a next lower lying (NLL) energy level relative to the TE energy level. The NLL energy level is spaced a second energy gap FMEG2 below the TE energy level, wherein a ratio of the FMEG2/HOSTPE is three or more.

Abstract: The technology disclosed relates to constructing a convolutional neural network-based classifier for variant classification. In particular, it relates to training a convolutional neural network-based classifier on training data using a backpropagation-based gradient update technique that progressively match outputs of the convolutional network network-based classifier with corresponding ground truth labels. The convolutional neural network-based classifier comprises groups of residual blocks, each group of residual blocks is parameterized by a number of convolution filters in the residual blocks, a convolution window size of the residual blocks, and an atrous convolution rate of the residual blocks, the size of convolution window varies between groups of residual blocks, the atrous convolution rate varies between groups of residual blocks. The training data includes benign training examples and pathogenic training examples of translated sequence pairs generated from benign variants and pathogenic variants.

Abstract: A process of recovering clean sand and active clay from sand or dust from a foundry is disclosed.

Abstract: A system includes: a processor; a memory coupled to the processor, wherein the memory stores a first content; a medical device coupled to the processor; and a reader coupled to the processor, wherein the reader is configured to read a second content from a storage medium other than the memory such that the processor switches the medical device from a first mode to a second mode based on the first content corresponding to the second content.

Abstract: Microdredging systems comprising a pumping platform and loading platform are described. In certain embodiments, system operates autonomously and is adapted to allow the loading platform undock from the pumping platform for disposal of the removed sediment.