Patents by Inventor A. Gregory Bruce

A. Gregory Bruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression systems for preparation of polypeptides in prokaryotic cells
    Patent number: 6194200
    Abstract: Expression cassettes for enhanced expression and production of a polypeptide of interest in prokaryotic cells are provided. The expression cassettes provide for production of the polypeptide of interest so that such polypeptide can either be secreted from the host cell in an active conformation or conveniently processed and renatured to a functional state. Preferably, the polypeptide of interest is expressed as a fusion protein, particularly fused to a leader sequence from a highly expressed bacterial or bacteriophage gene. The polypeptide of interest may subsequently be cleaved from the leader sequence and refolded, or used as a fusion protein.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: February 27, 2001
    Assignee: Oncogen
    Inventors: Timothy M. Rose, A. Gregory Bruce