Abstract: A mechanical lock for railway points comprising an outer tube and a linear arrangement of interlinked components arranged in a core of the outer tube, the interlinked components comprising five coaxially arranged, separately manufactured, elements, including a central tie and two link-rods, the two link rods being respectively interlinked at first ends thereof to opposing ends of the central tie by expandable components.

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract: A mechanical lock for railway points comprising an outer tube and a linear arrangement of interlinked components arranged in a core of the outer tube, the interlinked components comprising five coaxially arranged, separately manufactured, elements, including a central tie and two link-rods, the two link rods being respectively interlinked at first ends thereof to opposing ends of the central tie by expandable components.

Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.

Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.

Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract: Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein or DNA encoding such a protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

Abstract: This invention relates, first, to the discovery of IL-17RL, a receptor for members of the IL-17 cytokine family, particularly IL-17B. IL-17RL is naturally expressed from a 19-exon gene as a 720 amino acid protein and as any of 11 splice variants created from differential splicing of the 19 exons. The invention further relates to the discovery that IL-17B is involved in catabolic degradation of bone and cartilage and that bone and cartilage disorders can be ameliorated by pharmacological manipulation of IL-17B by antibodies or by using IL-17RL as a decoy to reduce IL-17B related catabolic activity. Methods for diagnosing cartilage disorders, and pharmaceutical compositions for slowing or ameliorating bone and cartilage pathologies are also provided.

Abstract: Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein or DNA encoding such a protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

Abstract: Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.