Abstract: A seat carrier subassembly for a valve includes an annular seat carrier body including an annular projection extending radially into a central passage, and an annular plastic seal ring over-molded onto the annular projection, with the annular plastic seal ring defining a seat seal.

Abstract: A banking pipeline for processing various transactions for multiple financial instruments is disclosed herein. The pipeline may have three distinct interpreters, a transaction interpreter, a rollup interpreter, and a rules interpreter. Different aspects of the transaction may be performed on separate interpreters and each interpreter may perform its aspect of the transaction before the next interpreter begins.

Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.

Abstract: Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.

Abstract: Generating a cybersecurity risk model using sparse data is disclosed, including: obtaining signals associated with a cybersecurity risk, wherein the obtained signals include technographic signals and query derived signals obtained from queries; generating pseudo signals based at least in part on a priori factors relating to the cybersecurity risk; and combining the pseudo signals and the obtained signals into a Bayesian model indicating the cybersecurity risk.

Abstract: A method to predict a propensity of an infant to develop atopic dermatitis. The method includes observing the expression of S100A8/A9 on a skin area of an infant; comparing the expression to determined standard, wherein the determined standard is ascertained by measuring a level of the biomarker in a subject or pool of subjects who have demonstrated an absence of atopic dermatitis; and determining the propensity of an infant to develop atopic dermatitis, wherein an increase in the expression as compared to the determined standard indicates propensity of the infant to develop atopic dermatitis.

Abstract: Piston-less downhole tools and piston-less pressure compensation tools are presented. The piston-less downhole tool includes a first chamber comprising a first fluid, the first fluid being a fluid that thermally expands in response to an increase in a temperature of the first fluid. The piston-less downhole tool also includes a tubular having a first end that is fluidly sealed and a second end that is in fluid communication with the first fluid, wherein the tubular is configured to expand in response to thermal expansion of the first fluid. The piston-less downhole tool further includes a second chamber configured to store a second fluid. The tubular of the piston-less downhole tool is configured to contract in response to pressure applied by the second fluid.

Abstract: Systems and methods for self-driving collision prevention are presented. The system comprises a self-driving vehicle safety system, having one or more sensors in communication with a control system. The control system is configured determine safety fields and instruct the sensors to scan a region corresponding to the safety fields. The control system determines exclusion regions, and omits the exclusion regions from the safety field. The safety system may also include capability reduction parameters that can be used to constrain the drive system of the vehicle, for example, by restricting turning radius and speed in accordance with the safety fields.

Abstract: The present disclosure relates to synchronized sharing of playlists from a source client device to a listening client device. To facilitate synchronized sharing, a current playlist of one or more tracks of digital content is obtained from the source client device. A current playback location within the currently playing playlist is also obtained from the source client device. A shared queue accessible by the listener client device is generated. Further, a shared queue context for the listener client device is identified based in part upon the current playback location. This enables the listener client device to start playback synchronized with the source client device.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.

Abstract: A pool cleaning brush including an attachment portion and at least one brush assembly. The attachment portion is configured for removably connecting with a portion of a tail sweep hose of a swimming pool cleaner. The at least one brush assembly includes at least one cleaning element thereon. As the swimming pool cleaner automatically moves through the swimming pool to clean the same, the pool cleaning brush is carried along with the tail sweep hose and engages the swimming pool surface to agitate, brush and clean the same.

Abstract: The disclosure features amphiphilic ligand conjugates comprising a chimeric antigen receptor (CAR)ligand and a lipid. The disclosure also features compositions and methods of using the same, for example, to stimulate proliferation of CAR expressing cells.

Abstract: Provided are structures and methods for doping polycrystalline thin film semiconductor materials in photovoltaic devices. Embodiments include methods for forming and treating a photovoltaic semiconductor absorber layer.

Abstract: A circuit package with improved thermal management is disclosed. In one aspect, a ceramic insert is provided within a package having heat-producing circuitry thereon. The ceramic insert replaces traditional laminate inserts and provides a better thermal path to remove heat from leads and/or traces within the package. More particularly, the ceramic insert more readily transfers and/or dissipates heat that might otherwise accumulate at an output port where a solder junction may be made to couple the output port to external elements.

Abstract: Examples of the disclosure are directed toward generating a causation score with respect to an agent and an outcome, and projecting a future causation score distribution. For example, a causation score may be determined with respect to a hypothesis that a given agent causes a given outcome, and the score may indicate the acceptance of that hypothesis in the scientific community, as described by scientific literature. A future causation score distribution, then, may indicate a probability distribution over possible future causation scores, thereby predicting the scientific acceptance of the hypothesis at some specific date in the future. A future causation score distribution can be projected by first generating one or more future publication datasets, and then determining causation scores for each of the one or more future publication datasets.

Abstract: Coordinated signal processing at at least a first and second transceiver integrated circuit (IC) configured to commonly process aggregated signal-port IQ data packets; and, each transceiver IC having a transmit signal processing circuit configured to process the commonly-processed aggregated signal-port IQ data packets in accordance with frequency-specific beam-tilt information received in control message packets. The frequency-specific electronic beam tilt may be applied to either a designated component carrier, or to a designated subset of subcarriers within a given component carrier.

Abstract: A catalyst obtainable by exsolving particles of Ni, Co and/or a mixture of Ni and Co from a perovskite metal oxide of formula (I) (M1aM2b)(COxNiyM3z)O3, wherein M1 and M2 are each independently an alkali earth metal or a rare earth metal, M3 is Ti or Cr, 0?a?1, 0?b?1, 0<a+b?1, 0?x<1, 0?y<1, 0?z<1, x+y+z=1 and where at least one of x and y>0. The invention includes methods of converting this catalyst into one or more catalytically active forms. The catalysts and the activated forms of same are useful in the catalysing CO oxidation and/or NO oxidation.

Abstract: Methods, apparatuses, and systems for two-way satellite communication and an asymmetric-aperture antenna for two-way satellite communication are disclosed. In one embodiment, a beam pattern for an asymmetric-aperture antenna is offset in a narrow beamwidth direction, and the offset beam pattern is directed by a mechanical gimbal, with the beam pattern offset made to reduce interference with an adjacent satellite. In additional embodiments, operational areas near the equator are identified for a given offset beam pattern, or a beam pattern offset may be adjusted over time to compensate for movement of the asymmetric-aperture antenna when attached to an airplane, boat, or other mobile vehicle.

Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.