Abstract: A method for applying a predetermined pattern of material onto an elongate tubular substrate includes securing a first portion of an elongate tube having a non-circular outer perimeter to an engagement member configured to be rotated by a first motor, such that the elongate tube can be rotated in unison with the engagement member, operating the first motor to rotate the elongate tube, operating a second motor of to change the relative displacement between the elongate tube and a dispensing conduit along a longitudinal axis of the elongate tube, and expelling a conductive adhesive from a fluid dispenser through the dispensing conduit to form a predetermined pattern of the conductive adhesive on a surface of the elongate tube, the predetermined pattern of the conductive adhesive covering at least 180 degrees of the surface along the non-circular outer perimeter over a width of at least two millimeters along the longitudinal axis.

Abstract: System comprises a headset and a host server. Headset comprises a wireless communication circuit for receiving content transmitted wirelessly to the headset. Headset comprises a right earphone and a left earphone, each comprising a speaker. Host server is in communication with the headset and is for wirelessly streaming the content to the wireless communication circuit. The host server is configured to prevent wireless streaming of prohibited content for playing by the headset based on a parental control applicable to the headset and a rating for the prohibited content.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 13 with aspartic acid. The TCRs may recognize G13D RAS presented by an HLA-DQ heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker and a body portion with an SOC. Each SOC comprises a wireless communication circuit and a processor. Each speaker is for playing audio streamed to the earphones in a lossy compressed format.

Abstract: Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with valine. The TCRs may recognize G12V RAS presented by an HLA-DR heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: Disclosed are methods of obtaining a cell population enriched for T cells with a phenotype, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample of a patient; (b) specifically selecting T cells with a phenotype comprising markers CD3+, CD39?, and CD69? from the bulk population; and (c) separating the cells selected in (b) from cells which lack the phenotype to obtain a cell population enriched for T cells with the phenotype. Related methods of treating or preventing cancer, methods of selecting a therapy for a cancer patient, and methods for predicting the clinical response to immunotherapy in a cancer patient are also disclosed. Isolated or purified cell population obtained according to the methods and related pharmaceutical compositions are also disclosed.

Abstract: Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a blood sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a TCR, preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker, a body portion, and an earbud extending from the body portion. The body portion comprises a downwardly extending portion that extends straight downwardly when the earphone is worn by the user, a wireless communication circuit for receiving signals transmitted wirelessly to the earphone from a remote source, a microphone, a rechargeable battery, a memory and a processor. Each earphone is configured to receive from a remote computing device, and store in the memory, a firmware update.

Abstract: Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a tumor sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a T cell receptor (TCR), preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker, a body portion, and an earbud extending from the body portion. The body portion comprises a downwardly extending portion that extends straight downwardly when the earphone is worn by the user, a wireless communication circuit for receiving signals transmitted wirelessly to the earphone from a remote source, a microphone, a rechargeable battery, a memory and a processor. Each earphone is configured to receive from a remote computing device, and store in the memory, a firmware update.

Abstract: Disclosed are isolated or purified T cell receptors (TCRs), wherein the TCRs have antigenic specificity for a mutated RAS amino acid sequence presented by a human leukocyte antigen (HLA) Class I molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker, microphone and a body portion with an SOC. Each SOC comprises a wireless communication circuit and a processor. Each processor comprises a digital signal processor for noise cancellation.

Abstract: A wireless earphone comprises a transceiver circuit for receiving streaming audio from a data source over a local ad hoc wireless network. When the data source and the earphone are out of range, they transition automatically to an infrastructure wireless network. If there is no common infrastructure wireless network for both the data source and the speakerphone set, the earphone connects to a host server via an available wireless network.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker and a body portion with an SOC. Each SOC comprises a wireless communication circuit and a processor. Each speaker is for playing audio streamed to the earphones in a lossy compressed format.

Abstract: Left and right earphones are independently wireless such that the left and right earphones are not physically connected when worn by a user. Each earphone comprises a speaker, microphone and a body portion with an SOC. Each SOC comprises a wireless communication circuit and a processor. Each processor comprises a digital signal processor for noise cancellation.

Abstract: Provided herein are methods of amplifying and detecting drug resistance markers (e.g., antibiotic resistance genes) from pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

Abstract: Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

Abstract: A wireless earphone comprises a transceiver circuit for receiving streaming audio from a data source over a local ad hoc wireless network. When the data source and the earphone are out of range, they transition automatically to an infrastructure wireless network. If there is no common infrastructure wireless network for both the data source and the speakerphone set, the earphone connects to a host server via an available wireless network.

Abstract: Provided herein are methods of amplifying and detecting pathogens and drug resistance markers (e.g., antibiotic resistance genes) in complex samples (e.g., blood), as well as related panels and compositions (e.g., primers, probes, magnetic particles, systems, cartridges, and kits). The methods, panels, and compositions can be used for comprehensive detection of pathogens and drug resistance markers for patient identification, patient selection, optimization of therapies, and antimicrobial stewardship.

Abstract: Provided herein are methods of detecting and sequencing target nucleic acids in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).