Patents by Inventor A. J. Tousimis
A. J. Tousimis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9426980Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: GrantFiled: April 14, 2015Date of Patent: August 30, 2016Inventor: Anastasios J. Tousimis
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Publication number: 20150216162Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: ApplicationFiled: April 14, 2015Publication date: August 6, 2015Inventor: Anastasios J. TOUSIMIS
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Patent number: 9027213Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: GrantFiled: July 21, 2014Date of Patent: May 12, 2015Inventor: Anastasios J. Tousimis
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Publication number: 20140329219Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: ApplicationFiled: July 21, 2014Publication date: November 6, 2014Inventor: Anastasios J. TOUSIMIS
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Patent number: 8685172Abstract: Processing and drying of a sample, such as a semiconductor or MEMS device, is performed in a single pressure chamber. The sample is sealed in the interior volume of the chamber, which has surfaces formed of a nickel-copper alloy. Hydroflouric acid (HF) is flowed into the sealed chamber to fill the interior volume and to contact the sample with HF. The HF is allowed to etch portions of the same for a desired time before removing the HF from the sealed chamber. After removal of the HF, the interior volume is cooled to a temperature less than 10° C. The sealed pressure chamber is filled with liquid carbon dioxide. The interior volume is then heated to a temperature greater than 31° C. and a pressure greater than 1072 psi (i.e., the critical point), after which gaseous carbon dioxide is exhausted from the sealed chamber to allow subsequent removal of the sample.Type: GrantFiled: May 1, 2013Date of Patent: April 1, 2014Inventor: Anastasios J. Tousimis
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Publication number: 20140020220Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: ApplicationFiled: September 27, 2013Publication date: January 23, 2014Inventor: Anastasios J. TOUSIMIS
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Patent number: 8563234Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: GrantFiled: February 23, 2012Date of Patent: October 22, 2013Inventor: Anastasios J. Tousimis
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Publication number: 20130239996Abstract: Processing and drying of a sample, such as a semiconductor or MEMS device, is achieved using a single pressure chamber. The pressure chamber holds the sample in a sealed interior volume throughout various process steps, such as, but not limited to, photoresist removal, sacrificial layer etching, flushing or rinsing, dehydration, and critical point drying. The pressure chamber is constructed of a chemically-resistant and pressure-resistant material to withstand the various chemicals and pressures that are encountered in the various process and drying steps. For example, the pressure chamber is constructed from a nickel-copper alloy. Automated release etching and critical point drying of a MEMS or semiconductor device is provided without removing the device from the sealed pressure chamber.Type: ApplicationFiled: May 1, 2013Publication date: September 19, 2013Inventor: Anastasios J. TOUSIMIS
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Publication number: 20130224724Abstract: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.Type: ApplicationFiled: February 23, 2012Publication date: August 29, 2013Inventor: Anastasios J. Tousimis
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Patent number: 8453656Abstract: Processing and drying of a sample, such as a semiconductor or MEMS device, is achieved using a single pressure chamber. The pressure chamber holds the sample in a sealed interior volume throughout various process steps, such as, but not limited to, photoresist removal, sacrificial layer etching, flushing or rinsing, dehydration, and critical point drying. The pressure chamber is constructed of a chemically-resistant and pressure-resistant material to withstand the various chemicals and pressures that are encountered in the various process and drying steps. For example, the pressure chamber is constructed from a nickel-copper alloy. Automated release etching and critical point drying of a MEMS or semiconductor device is provided without removing the device from the sealed pressure chamber.Type: GrantFiled: June 25, 2010Date of Patent: June 4, 2013Inventor: Anastasios J. Tousimis
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Publication number: 20130056036Abstract: Processing and drying of a sample, such as a semiconductor or MEMS device, is achieved using a single pressure chamber. The pressure chamber holds the sample in a sealed interior volume throughout various process steps, such as, but not limited to, photoresist removal, sacrificial layer etching, flushing or rinsing, dehydration, and critical point drying. The pressure chamber is constructed of a chemically-resistant and pressure-resistant material to withstand the various chemicals and pressures that are encountered in the various process and drying steps. For example, the pressure chamber is constructed from a nickel-copper alloy. Automated release etching and critical point drying of a MEMS or semiconductor device is provided without removing the device from the sealed pressure chamber.Type: ApplicationFiled: June 25, 2010Publication date: March 7, 2013Inventor: Anastasios J. Tousimis
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Publication number: 20090321248Abstract: A sputtering system includes a disk-shaped target concentric with an annular anode in a reaction chamber. A thermally-sensitive sample is arranged in the reaction chamber so as to receive material sputtered from the target. The thermally-sensitive sample can be a soft tissue biological specimen. A magnet is arranged proximal to the sample within the reaction chamber. The magnet can be a U-shaped magnet or one or more bar magnets. During sputtering from the target, the magnetic field of the magnet deflects the trajectory of secondary electrons generated by the sputtering process, thereby protecting the sample from heating and damage.Type: ApplicationFiled: June 29, 2009Publication date: December 31, 2009Inventor: Anastasios J. Tousimis
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Patent number: 6883674Abstract: Multipurpose holders for electronic components utilized during a fabrication process must allow the components to be submerged into baths of hydrofluoric acid, rinsed in de-ionized water (D.I.), placed into baths of alcohol for dehydration, and ultimately dried prior to further processing. The holders provide both fluid flow around the wafers while in each bath of fluid and while being processed by the critical point dryer, and a containment system to keep the wafer submerged in fluid at all times during the transfer between baths and the drying equipment.Type: GrantFiled: December 5, 2001Date of Patent: April 26, 2005Assignee: Tousimis Research CorporationInventors: Anastasios J. Tousimis, Chris Tousimis, Yianni Tousimis
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Patent number: 6678968Abstract: A critical point drying apparatus for sample preparation in electron microscopy and semiconductor wafer production includes a computer system to automate the operational modes in drying the specimen. These operational modes controlled by the computer system are: cooling, in which a drying chamber is cooled; starting, in which the specimen chamber is filled with a transitional fluid; purging, in which the transitional fluid purges an intermediary fluid from the drying chamber and the purged intermediary fluid is collected by a collector condenser; heating, in which the drying chamber is heated to elevate the transitional fluid to its critical point temperature and pressure; and bleeding, in which the drying chamber is depressurized to atmospheric pressure at a very slow rate until the drying chamber is completely vented, which signals the end of the drying operation. The computer system interfaces with a remote client terminal to update the status of the operation of the critical point drying apparatus.Type: GrantFiled: November 19, 2001Date of Patent: January 20, 2004Assignee: Tousimis Research CorporationInventors: Anastasios J. Tousimis, Chris Tousimis
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Patent number: 6493964Abstract: A critical point drying apparatus for sample preparation in electron microscopy and semiconductor wafer production includes a computer system to automate the operational modes in drying the specimen. These operational modes controlled by the computer system are: cooling, in which a drying chamber is cooled; starting, in which the specimen chamber is filled with a transitional fluid; purging, in which the transitional fluid purges an intermediary fluid from the drying chamber and the purged intermediary fluid is collected by a collector condenser; heating, in which the drying chamber is heated to elevate the transitional fluid to its critical point temperature and pressure; and bleeding, in which the drying chamber is depressurized to atmospheric pressure at a very slow rate until the drying chamber is completely vented, which signals the end of the drying operation. The drying chamber incorporates concave surfaces for pressure dispersal and to facilitate purging the intermediary fluid completely.Type: GrantFiled: September 8, 2000Date of Patent: December 17, 2002Assignee: Tousimis Research Corp.Inventors: Anastasios J. Tousimis, Chris Tousimis
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Patent number: 4104808Abstract: A semi-automatic critical point drying apparatus for the preparation of biological or organic specimens for examination thereof by scanning electron microscopy. In the preparation of such specimens, the specimen is placed in a chamber into which is introduced a transitional fluid, such as liquid CO.sub.2, which replaces the dehydrating liquid in the specimen as a part of the drying process. In critical point drying, the transitional fluid in the chamber is heated to elevate the chamber temperature and pressure above the critical point of the fluid. A five-way indicator valve replaces the manually adjustable valve of prior art apparatus for enabling the operator easily to control the cooling, filling, purging and bleeding operations of such a critical point drying apparatus.Type: GrantFiled: August 11, 1977Date of Patent: August 8, 1978Inventors: John E. Horne, Stephen A. Van Albert, A. J. Tousimis