Patents by Inventor A. James Link

A. James Link has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11338641
    Abstract: A system for cooling a heat generating component of a vehicle. The system includes a blower of a vehicle heating, ventilation, and air conditioning (HVAC) system. An air duct extends from the blower to the heat generating component to cool the heat generating component.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: May 24, 2022
    Assignee: DENSO International America, Inc.
    Inventors: Jason Hendry, James Link, Sanjay Singh
  • Patent number: 11312756
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: April 26, 2022
    Assignee: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Publication number: 20210237532
    Abstract: A system for cooling a heat generating component of a vehicle. The system includes a blower of a vehicle heating, ventilation, and air conditioning (HVAC) system. An air duct extends from the blower to the heat generating component to cool the heat generating component.
    Type: Application
    Filed: March 31, 2020
    Publication date: August 5, 2021
    Inventors: Jason HENDRY, James LINK, Sanjay SINGH
  • Publication number: 20210107950
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 15, 2021
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Mikhail O. Maksimov
  • Patent number: 10927152
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 23, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: A James Link, Mikhail O. Maksimov
  • Patent number: 10569621
    Abstract: The present disclosure provides a casing for an air conditioning unit including a main body, a door, a passing defining member, and a drain channel. The main body includes a fresh-air passage and a recirculation-air passage. The recirculation-air passage is positioned below the fresh-air passage. The door selectively opens and closes a communication hole through which the fresh-air passage and the recirculation-air passage are in fluid communication with each other. The passage defining member is disposed upstream of the communication hole and defines a lower side of the fresh-air passage. The drain channel extends from the passage defining member to a space outside of the recirculation-air passage to discharge condensed water generated in the fresh-air passage.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 25, 2020
    Assignee: DENSO International America, Inc.
    Inventors: Ercole Santilli, Ross Mischnick, James Link
  • Publication number: 20190309038
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: May 3, 2019
    Publication date: October 10, 2019
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Patent number: 10344064
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: July 9, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: A. James Link, Siyan Zhang
  • Publication number: 20190040107
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 7, 2019
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Mikhail O. Maksimov
  • Patent number: 10072048
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: September 11, 2018
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: A. James Link, Mikhail O. Maksimov
  • Publication number: 20170341484
    Abstract: The present disclosure provides a casing for an air conditioning unit including a main body, a door, a passing defining member, and a drain channel. The main body includes a fresh-air passage and a recirculation-air passage. The recirculation-air passage is positioned below the fresh-air passage. The door selectively opens and closes a communication hole through which the fresh-air passage and the recirculation-air passage are in fluid communication with each other. The passage defining member is disposed upstream of the communication hole and defines a lower side of the fresh-air passage. The drain channel extends from the passage defining member to a space outside of the recirculation-air passage to discharge condensed water generated in the fresh-air passage.
    Type: Application
    Filed: May 27, 2016
    Publication date: November 30, 2017
    Inventors: Ercole SANTILLI, Ross MISCHNICK, James LINK
  • Publication number: 20160376336
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: September 14, 2016
    Publication date: December 29, 2016
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Patent number: 9464125
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: October 11, 2016
    Assignee: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Publication number: 20160145916
    Abstract: A fastening device for securing a first component to a second component includes a latch coupled with the first component and a catch coupled with the second component. The fastening device further includes a convex portion formed with one of the latch and the catch and a concave portion formed with the other of the latch and the catch. The catch is configured to engage with the latch when the concave portion receives the convex portion.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 26, 2016
    Inventors: James Link, Nikolai Akinin
  • Patent number: 9114687
    Abstract: A dual joint block for pressing a seal against an air conditioner thermal expansion valve housing. The dual joint block includes a body having an inner face and an outer face. The body defines a first aperture and a second aperture. The first aperture extends through the body between the inner face and the outer face. The first aperture is configured to completely surround a first conduit extending therethrough. The second aperture extends through the body between the inner face and the outer face, and is configured to completely surround a second conduit extending therethrough.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 25, 2015
    Assignee: DENSO International America, Inc.
    Inventors: Nathan Dorland, James Link, Douglas Forsyth
  • Publication number: 20150225463
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Application
    Filed: August 29, 2013
    Publication date: August 13, 2015
    Inventors: A. James Link, Mikhail O. Maksimov
  • Publication number: 20150045310
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: February 4, 2013
    Publication date: February 12, 2015
    Inventors: A. James Link, Siyan Zhang
  • Publication number: 20140265307
    Abstract: A dual joint block for pressing a seal against an air conditioner thermal expansion valve housing. The dual joint block includes a body having an inner face and an outer face. The body defines a first aperture and a second aperture. The first aperture extends through the body between the inner face and the outer face. The first aperture is configured to completely surround a first conduit extending therethrough. The second aperture extends through the body between the inner face and the outer face, and is configured to completely surround a second conduit extending therethrough.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: DENSO INTERNATIONAL AMERICA, INC.
    Inventors: Nathan Dorland, James Link, Douglas Forsyth
  • Patent number: 7565734
    Abstract: An induction forging coil apparatus which makes induction forge coils easier and faster to change on a forge-line. The coil insert is a separate independent unit by itself which slides into the frame to connect to the frame via bus connections and other components. The coil insert is attached to the frame (another separate independent unit by itself) to complete the overall induction heating coil. The induction coil (with both units attached and operatively interconnected) can run on the forge line until it blows/fails, and instead of pulling the whole induction coil (both units attached) off-line to be rebuilt; the frame can be left on-line (or pulled off-line for a brief period of time if there is not enough room to reach the components due to the particular forge-line setup) to switch the failed insert with a new or rebuilt insert, by disconnecting the failed coil insert from the frame and then reconnecting the frame with the new or rebuilt coil insert.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: July 28, 2009
    Inventors: Jason D. Link, James Link
  • Publication number: 20080076819
    Abstract: A compound of formula (I): or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
    Type: Application
    Filed: April 5, 2007
    Publication date: March 27, 2008
    Applicant: Abbott Laboratories
    Inventors: Vince Yeh, Ravi Kurukulasuriya, David Madar, James Link