Abstract: The present invention relates to methods, compositions and dosages that decrease IOP of the eye, comprising a 19 nucleotide double-stranded RNA molecule.

Abstract: An oral care implement having a multi-component handle. The oral care implement may include a head and a handle. The handle may include a transparent component and an opaque component. The transparent component may have a front surface, a rear surface opposite the front surface, a first lateral surface, and a second lateral surface opposite the first lateral surface. The opaque component may at least partially cover the front and rear surfaces of the transparent component while leaving the first and second lateral surfaces of the transparent component exposed. Thus, the transparent component may form a window through the lateral surfaces of the handle.

Abstract: A method of fabricating a composite material part, the method including making a consolidated fiber preform, the fibers of the preform being carbon or ceramic fibers and being coated with an interphase; obtaining a consolidated and partially densified fiber preform, the partial densification comprising using chemical vapor infiltration to form a first matrix phase on the interphase; and continuing densification of the fiber preform by infiltrating an infiltration composition containing at least silicon and at least one other element suitable for lowering the melting temperature of the infiltration composition to a temperature less than or equal to 1150° C.

Abstract: An oral care implement having a cover member. In one aspect, the invention is an oral care implement comprising: a body comprising a handle and a head, the head comprising a coupling element; a store of oral care material located within the body; an outlet located on the head and in fluid communication with the store; a cover member comprising a cap portion, a mounting portion, and a coupling element; and wherein the cover member is detachably coupled to the head via cooperation between the coupling element of the cover member and the coupling element of the head, and the mounting portion is configured to mount the oral care implement to a vertical surface.

Abstract: A gallium nitride (GaN) power amplifier having a plurality of amplifier stages integrated into a monolithic integrated circuit is disclosed. The plurality of amplifier stages is coupled together between a radio frequency signal input and a radio frequency signal output, wherein at least one of the plurality of amplifier stages includes a first GaN transistor that is configured to have a first breakdown voltage that is no more than 75% of a second breakdown voltage of a second GaN transistor included in a different one of the plurality of amplifier stages.

Abstract: A catheter with a variable circular loop responsive to a contraction wire for coiling is supported by a member having a tapered distal section that transitions from a circular cross-section to a generally rectangular cross-section while maintaining a uniform cross-sectional area along the entire tapered length for improved coiling characteristics. A radially constrictive sleeve prevents separation of the contraction wire from the support member to minimize misshaping of the loop during contraction.

Abstract: A cooker hob device, in particular to an induction cooker hob device, includes at least one switching unit and at least one control apparatus. In order to obtain a high degree of efficiency, the control apparatus is constructed to automatically prompt the at least one switching unit in at least one operating cycle to switch in at least one entire first time interval using at least one switching parameter having a value which changes at least substantially continuously.

Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

Abstract: An exemplary elevator assembly includes an elevator car having a frame member. At least one toe guard panel is moveable between a first position and a second position. In the first position the toe guard panel is situated to provide a vertical surface beneath the elevator car and the toe guard panel has an end spaced a first distance from the elevator car. In the second position the toe guard panel is situated with a second, shorter distance between the end and the elevator car. A moving mechanism coupled with the toe guard panel selectively moves the toe guard panel from the first position into the second position. An instigator member situated in a selected vertical position interacts with the moving mechanism to begin movement of the toe guard panel from the first position when the frame member of the elevator car is approximately at the selected vertical position.

Abstract: A cooktop includes a plurality of heating elements, a user interface for inputting a power level, a detection assembly for detecting a position and size of at least one cookware element, and a control unit designed to combine a plurality of heating elements into a heating zone depending on the detected size and position of the cookware element and to operate the heating elements of the heating zone with a total heat output. In order to ensure a reproducible total heat output, the control unit is designed to calculate a bottom surface of the cookware element from the measurands of the detection assembly and to determine the total heat output depending on power level and bottom surface.

Abstract: Described herein are sets of metabolite and lipid (e.g., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps. Presented herein are illustrative pathology-linked panels. In certain embodiments, the markers presented herein (or subsets thereof) are used as a panel for detecting either colorectal cancer or adenomatous polyps at the same time. The markers presented herein include metabolites and lipids (e.g., fatty acid) freely detectable and accurately quantifiable in human serum. In certain embodiments, the sample may be plasma, urine, saliva, whole blood, dried blood spot or dried serum spot.

Abstract: The present invention relates to heterogeneous acid catalysts comprising or consisting of mixed metal salts, of lithium and aluminum phosphates and sulfates, and combinations with metallic cations, such as magnesium, titanium, zinc, zirconium and gallium, to provide adequate Lewis acidity; organic or inorganic porosity promoters, such as polysaccharides; and agglomerates, such as clays, kaolin and metal oxides of the type MxOy, where; M=Al, Mg, Sr, Zr or Ti, and other metals of groups IA, IIA and IVB, x=1 or 2 and y=2 or 3, for the formation of particles. A process is disclosed for obtaining from the catalyst by the hydrolysis of aluminum lithium hydride with water and oxygenated solvent, such as an ether. The catalysts are used in batch reactor and continuous flow systems in reactions that require moderate Lewis acidity, such as refining, petrochemical and general chemistry, including the transesterification of glycerides to produce alkyl esters.

Abstract: Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that integrate communication between the components of the sample preparation system. Also described herein are mass spectrometry-based analytical methods featuring efficient system calibration and sample analysis that provide for accurate quantification of a set of markers in biological samples. The methods are capable of automatic high sample throughput in a clinical setting for detection and quantification using a mass spectrometry system and high performance liquid chromatography column.

Abstract: A food mixer is presented having mixing tool detection capability. The food mixer has a base unit with a tool attachment portion, a mixing bowl attached to the base unit, and a motor attached to the base unit. The motor has operational settings and is configured to apply a torque to the tool attachment portion. A mixing tool is removably attached to the tool attachment portion, and a controller unit of the mixer is configured to detect the mixing tool attached to the tool attachment portion and to automatically control the operational settings of the drive motor based on the mixing tool detected. A magnet carrier may be used to detect a magnetic portion of the mixing tool as it moves with respect to a magnetically-sensitive sensor in the base unit.

Abstract: A method of repairing a section of a pipe including a breach in the pipe. A surface of a wall of the pipe is prepared generally around the breach. A piece of conformable material of the type capable of carrying a curable polymer is sized in relation to a size of the breach. The sized piece of conformable material is applied to the prepared surface so that the breach is covered by the piece of conformable material. The piece of conformable material is impregnated with a curable polymer. The curable polymer is cured within the piece of conformable material thereby to seal the breach against egress of groundwater into the pipe.

Abstract: Nowadays, one of the major problems of the oil industry is the presence of large amounts of water and salts, which cannot be efficiently removed by conventional dehydrating polymers. In addition, the acid stimulation operations of petroleum wells cause the chemical degradation of demulsifiers such as polyethers and phenolic resins, reducing drastically their efficiency as water and salt removers. Based on aforementioned, a series of new copolymers has been developed; these copolymers are combinations of an acrylic and an aminoacrylic monomer and they are synthesized by semi-continuous emulsion polymerization (under starved feed conditions), which ensures both the homogeneity of the different chains as well as the randomness of the monomers distribution. The solutions of one of these random copolymers have shown an efficiency similar or superior to combinations of two or three block copolymers (formulations), when they are applied in light or heavy crude oils.

Abstract: A macro cell video compression system and related method, the system including a first raster device and a second raster device that is cross-linked to the first raster device to move macro cells between the linked first and second raster devices, each of the first and second raster devices comprising a video raster circuit having a raster phase locking circuit to perform frame locking and pixel locking between the first and second raster devices and to generate macro cells by one of the first and second raster devices, each of the first and second raster devices has two or more raster heads that generate the macro cells by pixel clock stalling.

Abstract: A billiard chalking assembly for applying billiard chalk to a billiard cue includes bracelet that is worn around a wrist. A ball is provided and a billiard chalk is positioned in the ball. The ball is removably coupled to the bracelet thereby facilitating the billiard chalk to be accessible to a wearer of the bracelet. The ball is manipulated to facilitating the billiard chalk to chalk a billiard cue.

Abstract: Embodiments allow an IHS to be configured for different distributions of available PCIe bandwidth. An IHS is reconfigured by utilizing different PCIe riser cards that interface with the PCIe bus of the IHS and route different portions of the available PCIe lanes. PCIe bandwidth may be further distributed using an interposer card that allows a portion of the PCIe bandwidth to be routed to a PCIe device that is supported by the PCIe interposer card. The IHS may be reconfigured by manually switching the riser cards and interposer that are coupled to the IHS. The PCIe distribution is reconfigured without relying on hardware switching components that redirect PCIe lanes. The riser cards and the interposer are coupled to a PCIe baseboard connector of the IHS, where the baseboard connector is divided into two baseboard sub-connectors that each interface with the PCIe bus of the IHS.