Abstract: Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one ?-amino acid found in the native GLP-1 is replaced with a ?-amino acid residue, which may or may not be cyclically constrained. Pharmaceutical compositions containing the analogs are described, as are methods to treat diabetes, and methods to make proteolytically resistant GLP-1 analogs.

Abstract: In one embodiment, the invention can be a method for manager-to-employee communication, the method including receiving comment data from employee devices of employees of an organization, the comment data indicating employee comments to a survey topic; receiving contact-me data from a manager device indicating contact-me requests, the contact-me requests indicating that the manager desires the employees to contact the manager directly regarding the employee comments to the survey topic; receiving contact-me response data from the employee devices indicating whether the employees will contact the manager directly; and generating a manager rating based on the saved contact-me response data.

Abstract: Described herein are apparatuses, systems and methods for adaptive downlink scheduling and link adaptation. The methods including, at a base station connected to a user equipment (“UE”), determining an initial modulation and coding scheme (“MCS”) for a plurality of subframes to be transmitted to the UE, wherein each MCS relates to a coding rate value for the subframes, determining an MCS pattern for the plurality of subframes based on the initial MCS, wherein an MCS for one of the subframes has a higher coding rate value than the initial MCS, and transmitting the plurality of subframes to the UE according to the MCS pattern.

Abstract: Techniques are described for facilitating use of invocable services by applications in a configurable manner. In at least some situations, the invocable services are Web services or other network-accessible services that are made available by providers of the services for use by others in exchange for fees defined by the service providers. The described techniques facilitate use of such invocable services by applications in a manner configured by the application providers and the service providers, including to track use of third-party invocable services by applications on behalf of end users and to allocate fees that are charged end users between the applications and the services as configured by the providers of the applications and services. In some situations, the configured pricing terms for a service specify fees for end users that differ in one or more ways from the defined fees charged by the provider of that service.

Abstract: Embodiments relate generally to systems and methods for completing processes on a gas detector device using near-field communication between the gas detector device and an NFC tag. The NFC tag may communicate instructions or information to the gas detector device. The NFC tag may be located on or near a gas testing system, comprising gas deliver tube(s), gas tank(s), as well as other elements. In some embodiments, the gas detector device may comprise a single button to simplify interactions with the user.

Abstract: A novel isolated Pichia stipitis strain is provided. The strain is capable of fermenting at least a pentose sugar in the presence of one or more inhibitory substances to produce ethanol. A method of utilizing the strain to produce ethanol is also provided.

Abstract: In one example a management system for an autonomous vehicle, comprises a first image sensor to collect first image data in a first geographic region proximate the autonomous vehicle and a second image sensor to collect second image data in a second geographic region proximate the first geographic region and a controller communicatively coupled to the first image sensor and the second image sensor and comprising processing circuitry to collect the first image data from the first image sensor and second image data from the second image sensor, generate a first reliability index for the first image sensor and a second reliability index for the second image sensor, and determine a correlation between the first image data and the second image data. Other examples may be described.

Abstract: A luminaire component for use in a luminaire, said component comprising:— (i) an LED module on a first printed circuit board (PCB), the first PCB having a front face on which the LED module is located; (ii) a second PCB mounted forward of the front face of the first PCB; (iii) connection means adapted to connect the second PCB to the first PCB. The invention also extends to a luminaire bezel containing one or more sensors, where the bezel is removably attachable to the luminaire. The sensor(s) can measure one or more environmental characteristics and electrical and signal contacts between the bezel and the luminaire are provided. Preferably the electrical and signal contact means is cableless.

Abstract: An iterative method for finding which user characteristic data should be used for pruning a database of available HRTFs before selecting an HRTF from the database for a target user (target listener.) The selected HRTF is expected to be the one that is more suitable for target user. This is also referred to as having “personalized” the HRTF selection process for the target user. This is not about computing a suitable HRTF but rather how to use the user characteristic data to improve the chances of selecting the most appropriate one from a database of available HRTFs. Other aspects are also described and claimed.

Abstract: Certain aspects provide systems and methods for performing an operation on a B?-tree. A method comprises writing a message associated with the operation to a first slot in a first buffer of a first non-leaf node of the B?-tree in an append-only manner, wherein a first filter associated with the first slot is used for query operations associated with the first slot. The method further comprises determining that the first buffer is full and, upon determining to flush the message to a non-leaf child node, flushing the message in an append-only manner to a second slot in a second buffer of the non-leaf child node, wherein a second filter associated with the second slot is used for query operations associated with the second slot. The method further comprises, upon determining to flush the message to a leaf node, flushing the message to the leaf node in a sorted manner.

Abstract: Embodiments of the present disclosure describe highly soluble calcium lactate, methods of making the highly soluble calcium lactate, additive compositions based on the highly soluble calcium lactate, methods of administering the additive compositions, and the like.

Abstract: A method for predicting lane error based on an identifier of a lane segment is disclosed. The method includes receiving a predicted location in a lane segment of a plurality lane segments for a first vehicle traveling on the lane segment. The method includes receiving a determined location of the first vehicle in the lane segment for the first vehicle. The method includes determining a difference between the predicted location in the lane segment received for the first vehicle and the determined location of the first vehicle in the lane segment. The method includes providing the determined difference between the predicted location in the lane segment received for the first vehicle and the determined location of the first vehicle in the lane segment and an identifier of the lane segment as first training data to a lane error estimation model.

Abstract: The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass.

Abstract: A polymer-encapsulated mineral acid solution and a method for forming the polymer-encapsulated mineral acid solution. Introducing a strong mineral acid solution to a monomer solution occurs such that a primary emulsion that is a water-in-oil type emulsion forms. Introducing the primary emulsion to a second aqueous solution forms a secondary emulsion that is a water-in-oil-in-water type double emulsion. The monomer in the secondary emulsion is cured such a polymerized shell forms that encapsulates the strong mineral acid solution and forms the capsule. The strong mineral acid solution has up to 30 wt. % strong mineral acid. A method of stimulating a hydrocarbon-bearing formation using the polymer-encapsulated mineral acid solution includes introducing a capsule suspension into a fissure in the hydrocarbon-bearing formation to be stimulated through a face in a well bore. The capsule is maintained within the fissure until the polymer shell degrades.

Abstract: The present disclosure relates to a bicycle security system. The system comprises an alarm circuit having an alarm mechanism; and a sensor for sensing the displacement of a bicycle. The sensor is in communication with the alarm mechanism for activating the alarm mechanism if the displacement of the bicycle is greater than a predetermined threshold. A power source for powering the alarm circuit.

Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured as a syringe. The syringe may be configured to generate high-pressure within the syringe to inflate or deflate a medical device, such as a balloon, or to inject a substance, such as bone cement, into a bone, such as a vertebra. The syringe may include a pressure reduction mechanism used to depressurize the syringe.

Abstract: The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1: PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1-binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.

Abstract: A structural member includes a body having a first surface, a second surface, and an end surface at an end portion of the structural member. The end portion of the structural member includes a root protrusion extending radially outward from the second surface of the structural member along a root protrusion radius to an outer end of the root protrusion to define a root protrusion height extending from the second surface of the structural member to the outer end of the root protrusion. The root protrusion further includes a root protrusion width extending between an inner edge and an outer edge of the outer end of the root protrusion. The root protrusion radius, the root protrusion height, and the root protrusion width are configured to define a stress protected weld root region isolated beyond and away from a root stress flow path propagated through the body of the structural member.

Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.