Patents by Inventor A. Joshua Wand

A. Joshua Wand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced nuclear spin polarization
    Patent number: 9778335
    Abstract: The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 3, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Andrew Joshua Wand
  • ENHANCED NUCLEAR SPIN POLARIZATION
    Publication number: 20150130096
    Abstract: The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 14, 2015
    Inventor: Andrew Joshua Wand
  • SOLUBILIZATION AND STUDY OF MEMBRANE PROTEINS
    Publication number: 20110027911
    Abstract: Provided are methods for solubilizing a membrane protein in order to provide substantially homogeneous membrane proteins that are solubilized within reverse micelle systems at concentrations that are suitable for analytical study of such membrane proteins, including nuclear magnetic resonance spectroscopy. Also provided are substantially homogeneous membrane proteins that are solubilized within a reverse micelle system, as well as methods for the study of solubilized membrane proteins, and for the screening of drug candidates that target such membrane proteins.
    Type: Application
    Filed: January 9, 2009
    Publication date: February 3, 2011
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: A. Joshua Wand, Ronald W. Peterson, Joseph M. Kielec
  • High-resolution NMR spectroscopy of molecules encapsulated in low-viscosity fluids
    Patent number: 6486672
    Abstract: The present invention provides a method for reducing the correlation time for global tumbling for analysis of proteins and other macromolecules by NMR spectroscopy. The method comprises placing a macromolecule, hydrated and without significant structure perturbation, within a reverse micelle in a suitable fluid medium of low viscosity. A high pressure NMR cell for use with the method of the present invention is also disclosed.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: November 26, 2002
    Inventors: A. Joshua Wand, Mark R. Ehrhardt, Peter F. Flynn
  • NMR spectroscopy of large proteins
    Patent number: 6198281
    Abstract: The present invention provides a method for reducing the correlation time for global tumbling for analysis of proteins and other macromolecules by NMR spectroscopy. The method comprises placing a macromolecule, hydrated and without significant structure perturbation, within a reverse micelle in a suitable fluid medium of low viscosity. A high pressure NMR cell for use with the method of the present invention is also disclosed.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: March 6, 2001
    Assignee: The Research Foundation of State University of New York
    Inventors: A. Joshua Wand, Mark R. Ehrhardt, Peter F. Flynn