Abstract: Stable pharmaceutical compositions are provided, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: A bone plate includes a bone-contacting surface, an upper surface opposite the bone-contacting surface, and a hole having a circumference and extending from the upper surface to the bone-contacting surface. The hole includes a first portion having a plurality of substantially parallel lips, each lip extends around the circumference of the hole and defines a diameter of the hole. The diameters of the hole, as defined by the lips, decrease in a direction from the upper surface to a center of the hole and increase in a direction from the center of the hole toward the bone-contacting surface.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: Methods of enhancing or improving fertility are disclosed. Methods of extending reproductive longevity are disclosed. Methods of increasing oocyte mitochondrial mass or preventing a decrease of oocyte mitochondrial mass are disclosed. Methods of improving embryo development or improving embryo fertilization rate are disclosed. Methods of treating or preventing an ovarian disease or condition are disclosed. Methods of reducing, preventing, or delaying perimenopause, menopause, or a symptom thereof are disclosed. The methods include administering an Emblica extract or a compound constituent of or having a similarity score of at least 95% with a compound constituent of an Emblica extract, or Fucus extract or a compound constituent of or having a similarity score of at least 95% with a compound constituent of a Fucus extract, or a chebula extract or a compound constituent of or having a similarity score of at least 95% with a compound constituent of a chebula extract.

Abstract: This disclosure relates to techniques for determining and presenting an indication of a closest cellular service location in a wireless communication system. A wireless device may receive cellular connectivity event information. The wireless device may determine a closest cellular service availability location for the wireless device based at least in part on the cellular connectivity event information. An indication of the closest cellular service availability location may be presented via one or more user interface elements. The closet cellular service availability location may be different than a most recent cellular service availability location.

Abstract: In some implementations, a server device may receive event-based data associated with a user device, wherein the user device is communicatively coupled with the server device via an access point within a physical environment. The server device may determine, using a model, a status of the user device that is based on the event-based data, wherein the model is configured based on historical event data associated with historical events involving a plurality of other user devices that are associated with the user device. The server device may determine, based on the status indicating that the user device has likely been abandoned within the physical environment, a location associated with the user device. The server device may perform an action associated with the user device and the location.

Abstract: An apparatus, method, and system for converting a charge to a voltage.

Abstract: A portable device with integrated functions related to health, safety, and security is provided. The portable device includes a memory, a battery, a global positioning sensor (GPS), and an accelerometer. The portable device further includes a touch screen that is configurable to be in a locked state and an unlocked state. The portable device can operate in at least two different power modes and can operate a messaging functionality. The portable device can automatically coordinate with the messaging functionality to prepare for transmission a message to one or more contacts of the user for use in case of an emergency, including the current location of the portable device, in response to information received by the at least one processor, even when the touch screen is in a locked state, based on an input sequence indicative of an emergency event entered by a user of the portable device.

Abstract: According to the various aspects, the present disclosure is directed to printed circuit board assemblies having a plurality of printed circuit board units or modules that use board connectors for joining the printed circuit board units. In an aspect, the board connector has a first surface, which may be a top surface, and an opposing second surface, which may be a bottom surface, and a plurality of openings, including a first set of connector openings for providing electrical connections between the at least two plurality of printed circuit board units. In another aspect, a method that includes forming a first printed circuit board unit with a first connecting portion and a second printed circuit board unit with a second connecting portion, and the first and second connecting are electrically coupled with the printed circuit board connector.

Abstract: An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.

Abstract: A connected car and an onboard user equipment (UE) may establish independent cellular connections and may also establish a connection between each other. The UE establishes a first cellular link between the UE and a first network, establishes a connection with a connected car, wherein the connected car has a second cellular link between the connected car and a second network, evaluates one or more conditions and declares one of the first cellular link or the connection with the connected car a primary network interface for the UE based on, at least, the one or more conditions.

Abstract: The disclosed technology addresses the need in the art for a data loss prevention policy that is adapted to new and evolving uses of artificial intelligence tools, such as generative large language models. The present technology can use techniques such as word embeddings, or classifications using artificial intelligence tools to identify leakage of sensitive information in the context of generative large language models. The present technology can also identify and track the use of content created by artificial intelligence tools for uses within an organization.

Abstract: Various methods, apparatuses/systems, and media for proactive third party risk monitoring and management are disclosed.

Abstract: The present invention is directed to polyethylene-based compositions suitable for packaging applications, films, and articles. The polyethylene-based composition according to embodiments disclosed herein includes a polyethylene composition having a first polyethylene fraction and a second polyethylene fraction as well as a calcium salt of 1,2-cyclohexanedicarbodylic acid. The polyethylene-based composition can deliver a balance of properties, including barrier properties, for packaging applications.

Abstract: An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.

Abstract: Embodiments described herein relate to dynamic selection of radio access technologies (RATs) available for use by 5G wireless devices. Managing selection of RATs to use by a 5G (and 4G LTE) capable wireless device can improve performance, e.g., when an application requires a higher throughput and a 5G SA connection underperforms a 5G NSA connection or a 4G LTE connection. Wireless devices can provide geolocation tagged cellular wireless network information, e.g., network performance measurements and observed properties, to network-based servers that collate and organize the crowd-sourced cellular wireless network information into a location database. The wireless device can use the cellular wireless network information of the location database for a geolocation at which the wireless device is operating to estimate performance for alternate wireless connections and compare to measured performance of a currently used wireless connection to determine whether to switch wireless RAT connections.

Abstract: In a computer-implemented method for transformation of inconsistent environmental data, environmental data is received from a plurality of data sources, wherein each data source of the plurality of data sources is associated with a geographic region and maintains the environmental data using at least one data format of a plurality of disparate data formats, such that the environmental data is received in the plurality of disparate data formats. The environmental data is transformed from the plurality of disparate data formats into a consistent data format, such that the transformed environmental data is in a standardized format capable of direct comparison and analysis. The transformed environmental data is stored in a database configured to receive and perform searches on the transformed environmental data.

Abstract: Microstructure manufacturing apparatuses and methods are disclosed herein that enable the production of microstructures in an efficient, cost-effective manner that produces precise, high-quality microstructure products. In the manufacturing process for a microneedle array, for example, a template can be contacted against a surface of a continuous layer of a viscous polymer and separated from the surface to form a plurality of projections. The projections can then be solidified and laser cut at a predetermined distance from the surface to form the microstructure.

Abstract: Embodiments described herein relate to managing access to 5G cellular baseband resources for 5G-capable wireless devices. A wireless device can monitor application workloads by analyzing communication network performance requirements for a given application in-use or launching for future use along with system-level indications of overall device usage, battery level, and mobility status to determine whether access to 5G cellular baseband resources is recommended for an application. A 5G cellular baseband resource recommendation is provided for an application indicating a level of bandwidth in current use or expected for future use as well as a confidence metric in the bandwidth level indication. The 5G cellular baseband resource recommendation is used with additional device criteria to determine whether access to one or more 5G radio frequency bands is allowed.

Abstract: The present disclosure relates to compounds and methods for treating cancer, the methods comprising administering to the subject a compound of formula (1). In some embodiments, the disclosure provides compounds and methods for inhibiting IQGAP1.