Abstract: The invention relates to a method of generating bone marrow organoids from pluripotent stem cells wherein said method comprises: a) driving induced pluripotent stem cells (iPSCs) to form mesodermal aggregates; b) inducing vascular and hematopoietic commitment of the mesodermal aggregates by further culturing the mesodermal aggregates in medium, supplemented with recombinant BMP4, FGF2, VEGFA and SCF; c) embedding the mesodermal aggregates in a hydrogel, and incubating the hydrogel in a sprouting medium comprising: a media suitable for stem cell maintenance supplemented with cytokines for differentiation, to form bone marrow organoids; and optionally d) separating the bone marrow organoids from the hydrogel for further free culture.

Abstract: An electronic device may have a camera and a display. The display may be configured to display virtual reality content for a user in which no real-world content from the camera is displayed or mixed reality content in which a combination of real-world content from the camera and overlaid virtual reality content is displayed. Control circuitry in the device may adjust the display and camera while transitioning between virtual reality and mixed reality modes. The control circuitry may reconfigure the camera to exhibit a desired frame rate immediately upon transitioning from virtual reality mode to mixed reality mode. Transitions between modes may be accompanied by smooth transitions between frame rates to avoid visible artifacts on the display. The camera frame rate may be synchronized to the display frame rate for at least part of the transition between the virtual reality and mixed reality modes.

Abstract: Aspects of the present disclosure are directed to a method for synthesizing carbon quantum dots. The method includes reacting a mixture of a fruit waste material and deionized water hydrothermally in an autoclave at a reaction temperature in a range of 150° C. to 250° C. to form a carbon quantum dot containing suspension, centrifuging the carbon quantum dot containing suspension to separate the carbon quantum dots from a hydrochar, and filtering the carbon quantum dot containing suspension to obtain the carbon quantum dots. The carbon quantum dots have a size ranging from 2 to 10 nm. The carbon quantum dots have a Stokes shift of at least 150 nm at an excitation wavelength of 360 nm or lower.

Abstract: A method for ammonia (NH3) decomposition to hydrogen (H2) and nitrogen (N2) includes introducing and passing a H2-containing feed gas stream into a reactor containing an industrial waste-based nickel (Ni-SMR) catalyst at a temperature of 500 to 900° C. to form a reduced Ni-SMR catalyst; introducing and passing an NH3-containing feed gas stream through the reactor in contact with the reduced Ni-SMR catalyst at a temperature of 100 to 1000° C. thereby converting at least a portion of the NH3 to H2 and regenerating the Ni-SMR catalyst particles to form a regenerated Ni-SMR catalyst, and producing a residue gas stream leaving the reactor; and separating the H2 from the residue gas stream to generate a H2-containing product gas stream.

Abstract: A method of treating a connective tissue disorder in a patient. The method comprises orally administering colchicine in a therapeutically effective dose amount. This treatment could suppress the pathologic inflammation, fibrosis, or angiogenesis associated with such connective tissue disorders. As an example, the connective tissue disorder could be tendinopathy (such as carpal tunnel syndrome). The treatment may have various beneficial effects at the target connective tissue, such as reduced fibrosis, increased collagen turnover, increased extracellular matrix turnover, reduced inflammation, reduced angiogenesis, etc.

Abstract: A method for controlling a compressed air supply device of a compressed air system of a utility vehicle. The compressed air supply device has a compressor, an air dryer unit and a regeneration valve device and being operated in an operating mode with delivery phases and regeneration phases. In the method, a current humidity, e.g. a relative or absolute humidity, is ascertained in the compressed air system, a current dew point depression (c-DPD) is ascertained from the ascertained humidity, a target dew point depression (t-DPD) is ascertained from current and/or projected ambient temperature data (T0, T(t)) and/or from current and/or projected vehicle operating data, and a target dew point depression (t-DPD) is subsequently ascertained from current and/or projected ambient temperature data (T0, T(t)) and compared with the current dew point depression (c-DPD). The operating mode and/or the regeneration phases are subsequently set and/or changed.

Abstract: Early-stage design for complex engineering systems is a difficult task with significant impact on the final design and is performed under time constraints which restricts the number of options being considered. Present disclosure provides a framework for an early-stage generative design of engineering systems by performing systematic design space exploration and targeted design space exploration. Diverse design configurations are generated for given requirements following a systematic design space exploration of the entire architectural design space of the early-stage problem. In the targeted design space exploration stage, potential regions of the design space are identified to generate different alternatives to the diverse design configurations already generated during the systematic design space exploration stage for early-stage generative design of a given engineering system.

Abstract: A computer-implemented method for authenticating an online user includes steps including receiving, from a requestor server in communication with a merchant website, an authentication request message including authentication data collected from a user computing device during an online interaction with the merchant website. The steps also include extracting the authentication data from the authentication request message, and applying a risk-based authentication (RBA) engine to the authentication data to obtain RBA result data including a reason code that includes no more than three bytes of data. The steps further include causing the reason code to be embedded in an authorization request message generated during the online interaction and routed to a decisioning server via a payment network.

Abstract: Aspects of the disclosure relate to intelligently managing invoice processing using blockchain and mixed reality applications. The computing platform may receive invoices and may analyze the invoices to determine a priority order in which the invoices should be processed. The computing platform may use an auto-matching algorithm to identify errors within the invoice and to generate proposed solutions to fix the errors. The computing platform may transmit the invoice to an enterprise organization for modifications and may receive, from the enterprise organization, confidential data including a modified invoice. The computing platform may receive, from an entity associated with a transaction indicated on the invoice, a request to access the modified invoice using a mixed reality application. The computing platform may receive, from the entity and based on the entity's review of the modified invoice using the mixed reality application, approval to execute the modified invoice.

Abstract: An apparatus obtains a set of radio data comprising signal strength related values for radio signals transmitted by a transmitter with an association of each signal strength related value with a representation of a geographical location. The apparatus applies a frequency transform to the obtained set of radio data to obtain transform coefficients, each transform coefficient comprising a transform index and an associated transform value. The apparatus selects a subset of transform indices having more significant transform values than the remaining transform indices and compresses the transform indices by encoding each transform index exploiting a probability of occurrence of an index value of a respective transform index. The same or another apparatus decodes the compressed transform indices again for use in position operations.

Abstract: A memory accessed by rows and/or by columns in which an array of bits can be physically stored physical one-bit wide columns with each bit of the multi-bit wide logical column stored in a one-bit physical column in a different physical die. The multi-bit column is read by reading a one-bit physical column in each of the different physical die in parallel. The multi-bit wide logical column is arranged diagonally across M physical rows and M one-bit physical columns with each bit of the multi-bit wide logical column in the logical row stored in a different physical row and physical one-bit wide column in one of plurality of dies.

Abstract: Described are systems and methods for client side enrichment and transform via dynamic logic for analytics across various platforms for improved performance, features, and uses. Analytics data collected in client applications is transformed and enriched before being sent to the downstream pipeline using native code and logic bundled into the core application code. The additional logic specific to manipulation of analytics may be unbundled from client-side application code and still be executed on on-device to achieve the same result. The logic may be written in a single language, such as JavaScript, and run across all clients including web browser and mobile operating systems.

Abstract: Embodiments include a method. The method includes receiving, by the computer system, a first input. The method includes generating, by at least using a language detection model, a set of predicted languages. The method includes generating, using different translation models, a different language translation of the first input for each language in the set of predicted languages. The method includes generating, using a first question-answer model, a set of answers. The method includes performing a distribution-based correction, by at least using a distribution source and at least one answer included in the set of answers, to determine the attribute represented by the arbitrary values included in the first input. The method includes causing a device to present a recommendation based at least in part on the attribute represented by the arbitrary values included in the first input.

Abstract: The invention relates to a method and a device for communication between a communication system of a vehicle (10) and a public land mobile network (100). To this end, a first piece of information representative of the current power consumption of the vehicle (10) is received; a second piece of information representative of an amount of electricity available in the vehicle (10), for example in the battery of the vehicle (10), is received; and a third piece of information representative of the target time during which the vehicle (10) wishes to remain connected to the network (100) is received. Based on the first, second and third pieces of information, the network (100) determines which power saving mode should be assigned to the communication system of the vehicle (10) so that the vehicle can maintain a connection to the network (10) for the desired time.

Abstract: A process and apparatus for producing biofuel from biorenewable feedstock is disclosed. The process comprises hydrotreating the biorenewable feed stream in a hydrotreating reactor to hydrodeoxygenate a biorenewable feed stream to provide a hydrotreated effluent stream. The hydrotreated effluent stream is separated in a hot separator into a hot separated vapor stream and a hot separated liquid stream. A hydroisomerization feed stream is taken from the hot separated liquid stream and hydroisomerized in a hydroisomerization reactor to provide a hydroisomerized stream. All or a portion of a return stream taken from the hot separated vapor stream is recycled to the hydroisomerization reactor. The disclosed process and apparatus minimize the carryover of the normal C16 to the biofuel and maximizes the hydroisomerization of n-paraffin hydrocarbons in the hydrotreated effluent stream to produce a biofuel which meets the biofuel specification without affecting or compromising the biofuel yield.

Abstract: A lighting unit including a hollow hemispherical body, a hemispherical holder, and a sphere. A center of a bottom half of the hollow hemispherical body contains the hemispherical holder which is configured to hold the sphere. The sphere includes a light source, a translucent portion, and an opaque portion. The light source is disposed inside of the sphere, and the sphere is configured to rotate within the hemispherical holder so as to vary a position of light emitted by the light source through the translucent portion.

Abstract: The present disclosure provides a method of reducing body weight, body fat mass, liver fat in a subject who has an abnormal HbAlc level, comprising administering to the subject a therapeutically effective amount of 5-[(2,4-initrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole, or a pharmaceutically acceptable salt thereof.

Abstract: Methods of stimulating a hydrocarbon reservoir having carbonate components are described herein. An acid treatment material is developed by defining a diversion parameter as a ratio of volume of diversion material to be used for treatment of the reservoir to volume of fractures to be developed during acid treatment of the reservoir, defining a relationship between the diversion parameter and a diversion result, selecting a value of the diversion parameter based on the relationship, determining an amount of diversion material based on the selected value of the diversion parameter, and adding the amount of the diversion material to an acid treatment material. The reservoir is then subjected to acid treatment using the acid treatment material.

Abstract: Microfluidic-based fiber formation methods and systems employ a computer vision and deep learning system and method to enable contactless sensing, analysis, and monitoring of key operational parameters within microfluidic crosslinking printheads on 3D bioprinters. Embodiments may employ object detection and/or semantic segmentation to facilitate the sensing, analysis, and monitoring. Deep learning can employ convolutional neural networks to localize and analyze the flow of different biological materials within the microchannels as well as to identify the operation of various microfluidic printhead on-chip components that can impact final quality of printed tissues. Printed tissues can include single-material fibers, including hollow filorezbers, as well as more complex coaxially-layered fibers.

Abstract: The present disclosure provides a method of preserving skeletal muscle mass during weight loss.