Patents by Inventor A. Look

A. Look has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOTCH mutations leading to increased receptor signaling
    Publication number: 20070077245
    Abstract: The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
    Type: Application
    Filed: August 2, 2005
    Publication date: April 5, 2007
    Applicants: The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Jon Aster, Stephen Blacklow, A. Look, Adolfo Ferrando, Andrew Weng