Patents by Inventor A.M. James Shapiro

A.M. James Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF ANTI-AGING GLYCOPEPTIDES TO ENHANCE PANCREATIC CELL HEALTH, SURVIVAL AND IMPROVE TRANSPLANT OUTCOME
    Publication number: 20230414675
    Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
    Type: Application
    Filed: September 7, 2023
    Publication date: December 28, 2023
    Inventors: Lachlan Grant Young, A.M. James Shapiro
  • TNFRSF25-MEDIATED TREATMENTS OF IMMUNE DISEASES AND DISORDERS
    Publication number: 20220340672
    Abstract: The present disclosure is directed to a method of treating or preventing diabetes, prediabetes, and/or glucose intolerance using TNF Receptor Superfamily Member 25 (TNFRSF25) agonistic antibody or antigen binding fragment thereof. The disclosure is also directed to methods for increasing graft survival and for treating or preventing graft-versus-host disease (GVHD) using TNFRSF25 agonistic antibody.
    Type: Application
    Filed: September 28, 2020
    Publication date: October 27, 2022
    Inventors: Matthew M. SEAVEY, Jeff T. HUTCHINS, Rahul R. JASUJA, A.M. James SHAPIRO, Braulio A. MARFIL-GARZA
  • USE OF ANTI-AGING GLYCOPEPTIDES TO ENHANCE BETA CELL HEALTH, SURVIVAL AND IMPROVE TRANSPLANT OUTCOME
    Publication number: 20210023142
    Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
    Type: Application
    Filed: September 30, 2020
    Publication date: January 28, 2021
    Inventors: Lachlan Grant Young, A.M. James Shapiro
  • Cellular transplant site
    Patent number: 10434122
    Abstract: A method of preparing a transplant site for cellular transplantation in a mammal includes the steps of inserting a foreign body comprising a biomaterial into an internal tissue; and removing the foreign body after the tissue surrounding the foreign body has undergone an inflammatory response but before significant fibrous encapsulation has occurred, leaving a neovascularized lumen suitable to receive transplanted cells or islets.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: October 8, 2019
    Inventor: A. M. James Shapiro
  • USE OF ANTI-AGING GLYCOPEPTIDES TO ENHANCE PANCREATIC CELL HEALTH SURVIVAL AND IMPROVE TRANSPLANT OUTCOME
    Publication number: 20170360844
    Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
    Type: Application
    Filed: June 23, 2017
    Publication date: December 21, 2017
    Inventors: Lachlan Grant Young, A.M. James Shapiro
  • CELLULAR TRANSPLANT SITE
    Publication number: 20160082158
    Abstract: A method of preparing a transplant site for cellular transplantation in a mammal includes the steps of inserting a foreign body comprising a biomaterial into an internal tissue; and removing the foreign body after the tissue surrounding the foreign body has undergone an inflammatory response but before significant fibrous encapsulation has occurred, leaving a neovascularized lumen suitable to receive transplanted cells or islets.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 24, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: A.M. James SHAPIRO
  • USE OF ANTI-AGING GLYCOPEPTIDES TO ENHANCE PANCREATIC CELL HEALTH, SURVIVAL AND IMPROVE TRANSPLANT OUTCOME
    Publication number: 20150352155
    Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
    Type: Application
    Filed: June 2, 2015
    Publication date: December 10, 2015
    Inventors: A.M. James Shapiro, Lachlan Grant Young