Patents by Inventor A. MacLeod

A. MacLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of histone deacetylase
    Publication number: 20070105808
    Abstract: The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
    Type: Application
    Filed: November 9, 2006
    Publication date: May 10, 2007
    Applicant: MethylGene, Inc.
    Inventors: A. MacLeod, Zuomei Li, Jeffrey Besterman
  • Combined therapy utilizing reduction of DNA methyltransferase expression and/or activity and interferon
    Publication number: 20060252723
    Abstract: The invention provides methods for the treatment of cancer comprising a reduction of DNA methyltransferase expression and/or activity and treatment and/or induction of interferon.
    Type: Application
    Filed: March 30, 2006
    Publication date: November 9, 2006
    Inventors: A. MacLeod, Gregory Reid, Jeffrey Besterman, Ernest Borden, Frederic Reu