Abstract: The present invention relates to electrospun fibres containing: i) a first and a second hydrophilic fibre-forming polymer that is soluble in a hydrophilic solvent, ii) a bioadhesive substance that is slightly soluble in said hydrophilic solvent, iv) a drug substance, wherein the first hydrophilic polymer has a solubility in water at 37° C. that is at least 10 times greater than the solubility in water at 37° C. of the second hydrophilic fibre-forming polymer, and wherein the bioadhesive substance is present in solid form.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

Abstract: The present disclosure concerns a hearing device (10) with improved sealing and providing easy exchange of for example covers and/or filters and/or sealings in/on the hearing device.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: The present invention is directed to use of the GLP-1 receptor agonist semaglutide in medical therapy for the treatment of non-alcoholic steatohepatitis.

Abstract: Techniques are discussed for predicting locations of an object based on attributes of the object and/or attributes of other object(s) proximate to the object. The techniques can predict locations of a pedestrian proximate to a crosswalk as they traverse or prepare to traverse through the crosswalk. The techniques can predict locations of objects as the object traverses an environment. Attributes can comprise information about an object, such as a position, velocity, acceleration, classification, heading, relative distances to regions or other objects, bounding box, etc. Attributes can be determined for an object over time such that, when a series of attributes are input into a prediction component (e.g., a machine learned model), the prediction component can output, for example, predicted locations of the object at times in the future. A vehicle, such as an autonomous vehicle, can be controlled to traverse an environment based on the predicted locations.

Abstract: Techniques are discussed for predicting locations of an object based on attributes of the object and/or attributes of other object(s) proximate to the object. The techniques can predict locations of a pedestrian proximate to a crosswalk as they traverse or prepare to traverse through the crosswalk. The techniques can predict locations of objects as the object traverses an environment. Attributes can comprise information about an object, such as a position, velocity, acceleration, classification, heading, relative distances to regions or other objects, bounding box, etc. Attributes can be determined for an object over time such that, when a series of attributes are input into a prediction component (e.g., a machine learned model), the prediction component can output, for example, predicted locations of the object at times in the future. A vehicle, such as an autonomous vehicle, can be controlled to traverse an environment based on the predicted locations.

Abstract: Methods and systems are described for automatically communicating transaction steps to users, and confirming completion of the transaction steps. The methods and systems may include receiving a transaction category, retrieving all transaction step activities and suggested transaction step activities of the transaction category, transmitting the retrieved transaction step activities and suggested transaction step activities through a network to a buyer and to a seller. The responses may include a transaction response, and an ignore indicator for each transaction step. The method may then include storing the transaction responses in a responses database, and updating the transaction step activities in a transaction steps database. The method may also include reviewing the transaction steps database and re-categorizing transaction step activities.

Abstract: Techniques are discussed for predicting locations of an object based on attributes of the object and/or attributes of other object(s) proximate to the object. The techniques can predict locations of a pedestrian proximate to a crosswalk as they traverse or prepare to traverse through the crosswalk. The techniques can predict locations of objects as the object traverses an environment. Attributes can comprise information about an object, such as a position, velocity, acceleration, classification, heading, relative distances to regions or other objects, bounding box, etc. Attributes can be determined for an object over time such that, when a series of attributes are input into a prediction component (e.g., a machine learned model), the prediction component can output, for example, predicted locations of the object at times in the future. A vehicle, such as an autonomous vehicle, can be controlled to traverse an environment based on the predicted locations.

Abstract: Techniques are discussed for predicting locations of an object based on attributes of the object and/or attributes of other object(s) proximate to the object. The techniques can predict locations of a pedestrian proximate to a crosswalk as they traverse or prepare to traverse through the crosswalk. The techniques can predict locations of objects as the object traverses an environment. Attributes can comprise information about an object, such as a position, velocity, acceleration, classification, heading, relative distances to regions or other objects, bounding box, etc. Attributes can be determined for an object over time such that, when a series of attributes are input into a prediction component (e.g., a machine learned model), the prediction component can output, for example, predicted locations of the object at times in the future. A vehicle, such as an autonomous vehicle, can be controlled to traverse an environment based on the predicted locations.

Abstract: An aspect of the invention provides a roll restrictor system for an automotive powertrain, comprising: a torque roll restrictor bracket configured for attachment to the automotive powertrain; wherein attachment is mediated by a bushing; wherein the bushing is provided within a bearing which facilitates rotation of the bushing within the torque roll restrictor bracket.

Abstract: An aspect of the invention provides a roll restrictor system for an automotive powertrain, comprising: a torque roll restrictor bracket configured for attachment to the automotive powertrain; wherein attachment is mediated by a bushing; wherein the bushing is provided within a bearing which facilitates rotation of the bushing within the torque roll restrictor bracket.

Abstract: A press (1) including: —a frame (2); —a first press bed (3) with a first tool part (4), wherein the first press bed (3) is provided between the frame (2) and the first tool part (4); —first displacement means (5); —a second press bed (6) with a second tool part (7) which in use is arranged at a position opposite to the first tool part (4), and where the second press bed (6) is provided between the frame (2) and the second tool part (7); —a device (8) for introducing workpieces (9) between the first (4) and the second tool parts (7); —a device (10) for ejecting finished workpieces (9?); —a punch (11) which is vertically displaceable through coaxial openings (13, 14) between the first tool part (4) and the second tool part (7); —a punch cylinder (15) for displacing the punch (11), wherein the press furthermore includes second displacement means (16) which are connected between the frame (2) and the second tool part (7) for horizontal displacement of the second tool part (7) between a pressing position with the

Abstract: A system for overseeing implementations of organizational policies, procedures, and/or directives. A host identifies parties involved in the implementations and tracks implementation statuses by (a) issuing notices for access by the identified parties, (b) with each notice, providing actions selectable as a response to the notice, and (c) tracking responses by the identified parties. In response to a predefined event, a user device associated by the host with one of the identified parties polls the host to determine whether a notice is pending for the associated party, and if so, provides an alert. Based on a user response to the alert, the user device displays the pending notice via a browser, and sends to the host via the browser a user-selected response to the pending notice. The host leaves the notice pending until the host receives a user-selected response.

Abstract: The present invention discloses novel compounds of Formula I: (I) having 11-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11-HSD type 1 activity.

Abstract: A hearing aid (22) having a microphone (1), a processor (53) and an output transducer (12), is adapted for obtaining an estimate of a sound environment, determining an estimate of the speech intelligibility according to the sound environment estimate, and for adapting the transfer function of the hearing aid processor in order to enhance the speech intelligibility estimate. The method according to the invention achieves an adaptation of the processor transfer function suitable for optimizing the speech intelligibility in a particular sound environment. Means for obtaining the sound environment estimate and for determining the speech intelligibility estimate may be incorporated in the hearing aid processor, or they may be wholly or partially implemented in an external processing means (56), adapted for communicating data to the hearing aid processor via an appropriate link.

Abstract: A press (1) including:—a frame (2);—a first press bed (3) with a first tool part (4), wherein the first press bed (3) is provided between the frame (2) and the first tool part (4);—first displacement means (5);—a second press bed (6) with a second tool part (7) which in use is arranged at a position opposite to the first tool part (4), and where the second press bed (6) is provided between the frame (2) and the second tool part (7);—a device (8) for introducing work-pieces (9) between the first (4) and the second tool parts (7);—a device (10) for ejecting finished workpieces (9?);—a punch (11) which is vertically displaceable through coaxial openings (13, 14) between the first tool part (4) and the second tool part (7);—a punch cylinder (15) for displacing the punch (11), wherein the press furthermore includes second displacement means (16) which are connected between the frame (2) and the second tool part (7) for horizontal displacement of the second tool part (7) between a pressing position with the opening

Abstract: A hearing aid (30) includes a microphone (71), a signal processor (20) and an output transducer (22), and the signal processor (20) includes a set of audio processing parameters mapped to a set of stored noise classes (12) and a noise classification block (8) for classifying the background noise for the purpose of optimizing the frequency response in order to minimize the effects of the background noise. The hearing aid may further include a neural net for controlling the frequency response. A method for reducing a noise component in a signal includes the steps of classification of the noise component, comparing the noise component to a set of known noise components, and adapting the processed audio signals according to a corresponding set of frequency response parameters.

Abstract: A hearing aid (22) having a microphone (1), a processor (53) and an output transducer (12), is adapted for obtaining an estimate of a sound environment, determining an estimate of the speech intelligibility according to the sound environment estimate, and for adapting the transfer function of the hearing aid processor in order to enhance the speech intelligibility estimate. The method according to the invention achieves an adaptation of the processor transfer function suitable for optimizing the speech intelligibility in a particular sound environment. Means for obtaining the sound environment estimate and for determining the speech intelligibility estimate may be incorporated in the hearing aid processor, or they may be wholly or partially implemented in an external processing means (56), adapted for communicating data to the hearing aid processor via an appropriate link.