Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for detecting polynucleotides from and within cells and tissues.

Abstract: Systems and methods for detecting interception devices. In some aspects, the system causes transmission of a first detection signal. Based on receiving a first response signal, the system determines a first probability of detection of a first interception device. Based on the first probability of detection, the system transmits a first command to deactivate a user authentication interface. The system may cause transmission of a second detection signal and determine a second probability of detection of a second interception device. In response to the second probability, the system may transmit a second command to reactivate the user authentication interface.

Abstract: A method for constructing a fiber array includes a) selecting a fiber spool among one or more fiber spools; b) processing a portion of the fiber spool to form an optical fiber having an output end; c) positioning a substrate at a position of a plurality of positions; and d) aligning the output end of the optical fiber to the substrate. The method also includes e) coupling the output end of the optical fiber to a location of a plurality of locations on the substrate; f) detaching the optical fiber from the fiber spool to form an input end of the optical fiber; and g) marking the optical fiber. The method further includes repeating c) through g) for each of the plurality of locations on the substrate determining that the substrate has been positioned at each of the plurality of positions.

Abstract: The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: An apparatus comprising a compact, folded path cell for optical gas detection and/or measurement utilising gas absorption spectroscopy. The apparatus includes a source of electromagnetic radiation, a gas sample cell containing reflective elements, and a detector of electromagnetic radiation. The source and detector are arranged between the reflective elements in an arrangement that reflects the radiation away from the source and detector until the reflected radiation has an adequate optical path length, and then reflects the radiation towards the detector. A spectroscopic analysis can be used to determine the presence and/or to measure at least one parameter of at least one gas species within a gas sample.

Abstract: An apparatus for optical gas detection and/or measurement in an absorption spectroscopy system comprising: a gas cell for containing a gas sample or calibration gas with at least one gas exchange port and at least one optical element for allowing transmission of electromagnetic radiation of a desired wavelength range in and out of the gas cell; and at least one source of converging, diverging or collimated electromagnetic radiation for transmitting electromagnetic radiation through a gas sample contained within the gas cell and towards at least one detector; said detector to monitor absorption of electromagnetic radiation for at least one absorption wavelength or wavelength range associated with at least one gas species, by detecting transmitted electromagnetic radiation that is not absorbed; at least one analyser for analysing an output signal from the at least one detector to measure a parameter of at least one gas species within the gas sample, characterised in that at least one dead volume within the spec

Abstract: An apparatus for use in absorption spectroscopy, comprising: at least one source of electromagnetic radiation for transmitting electromagnetic radiation along an optical path that passes through a gas measurement volume, towards at least one detector; at least one detector to detect the transmitted electromagnetic radiation after passing through the gas measurement volume and to provide an output signal indicative of the detected electromagnetic radiation; and an analyser connected to the at least one detector to receive the output signal and analyse the effects of absorption by at least one gas species within the gas measurement volume for at least one wavelength range of the transmitted electromagnetic radiation, thereby to detect or measure a parameter of the at least one gas species; wherein at least one source or detector comprises a Chip-on-Board (COB) component comprising a solid-state source and/or detector of electromagnetic radiation mounted onto a substrate in a COB configuration.

Abstract: Disclosed herein, inter alia, are polynucleotide probes, methods, and kits useful for amplifying and detecting target nucleic acids.

Abstract: Disclosed herein, inter alia, are oligonucleotides, methods, and kits useful for amplifying and detecting target nucleic acids.

Abstract: Disclosed herein, inter alia, are oligonucleotides, methods, and kits useful for amplifying and detecting targets such as nucleic acids, proteins, and carbohydrates.

Abstract: Disclosed herein, inter alia, are methods and compositions for improved circular polynucleotide amplification and detection.

Abstract: Disclosed herein, inter alia, are oligonucleotides, methods, and kits useful for amplifying and detecting targets such as nucleic acids, proteins, and carbohydrates.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A quantitative simulation process for producing quantitative model predictions of hydrocarbon composition. The quantitative simulation may include measuring a chemical and isotopic composition of a hydrocarbon sample from a hydrocarbon reservoir.

Abstract: A respiratory flow therapy apparatus including a sensing chamber which measures a flow of gases provided to a patient. The sensing chamber can be located after a blower and/or mixer. The sensing chamber can include an ultrasonic transducer, a temperature sensor, a heated temperature sensing element, and/or a gas concentration sensor. A flow path of gases used in conjunction with the sensor system prevents unwanted vorticity in the flow of gases that can create anomalies in measuring flow.

Abstract: A respiratory flow therapy apparatus including a sensing chamber which measures a flow of gases provided to a patient. The sensing chamber can be located after a blower and/or mixer. The sensing chamber can include an ultrasonic transducer, a temperature sensor, a heated temperature sensing element, and/or a gas concentration sensor. A flow path of gases used in conjunction with the sensor system prevents unwanted vorticity in the flow of gases that can create anomalies in measuring flow.

Abstract: A method and system for the suppression and/or modulation of absorption spectrum artifacts for the purpose of gas detection and concentration measurements using at least one magnetic, electric or electromagnetic field. A field applied selectively to at least one section of the system modulates absorption by influencing quantum energy state transitions of gas species.

Abstract: An apparatus for delivering a flow of gas, has a housing 3202? with a recess, and an outlet port 3210? for a flow of gas. The recess is defined by at least one wall 3256, 3262 that is substantially continuous, gas impermeable, and unbroken, other than a gasflow passage from the recess to the outlet port of the housing.