Patents by Inventor A. Michael Sismour

A. Michael Sismour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemically cleavable phosphoramidite linkers for sequencing by ligation
    Patent number: 8530156
    Abstract: Linkers and methods for determining a nucleotide sequence of a reference oligonucleotide are provided.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: September 10, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, A. Michael Sismour
  • Methods and compounds for chemical ligation
    Patent number: 8481258
    Abstract: Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: July 9, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, A. Michael Sismour
  • Amplification of oligonucleotides containing non-standard nucleobases
    Patent number: 8354225
    Abstract: This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims processes for amplifying nucleic acid analogs containing non-standard nucleobases using polymerase chain reactions, and enzymes that perform this amplification.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: January 15, 2013
    Inventors: Steven Albert Benner, Albert Michael Sismour
  • ENZYMATIC OLIGONUCLEOTIDE PRE-ADENYLATION
    Publication number: 20120058521
    Abstract: Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided.
    Type: Application
    Filed: November 2, 2011
    Publication date: March 8, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, François Vigneault, A. Michael Sismour
  • Using thymidine analogs to improve replication in an expanded genetic alphabet
    Patent number: 7794936
    Abstract: This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims processes for amplifying nucleic acid analogs containing non-standard nucleobases using polymerase chain reactions, and combinations of non-standard nucleobases, analogs of standard nucleotides, and enzymes that perform this amplification.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 14, 2010
    Inventors: Steven Albert Benner, Albert Michael Sismour
  • Methods and Compounds For Chemical Ligation
    Publication number: 20100092988
    Abstract: Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided.
    Type: Application
    Filed: December 1, 2009
    Publication date: April 15, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, A. Michael Sismour
  • CHEMICALLY CLEAVABLE PHOSPHORAMIDITE LINKERS FOR SEQUENCING BY LIGATION
    Publication number: 20100081140
    Abstract: Linkers and methods for determining a nucleotide sequence of a reference oligonucleotide are provided.
    Type: Application
    Filed: July 31, 2009
    Publication date: April 1, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, A. Michael Sismour
  • ENZYMATIC OLIGONUCLEOTIDE PRE-ADENYLATION
    Publication number: 20100062494
    Abstract: Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided.
    Type: Application
    Filed: July 31, 2009
    Publication date: March 11, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, François Vigneault, Michael Sismour