Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.

Abstract: A rotatable line transfer mechanism for a fishing reel includes a substantially hemispherical cap (SHC) and a securing mechanism. The SHC includes an outwardly curved hemispherical upper section (OCHUS) and a wall extending vertically downwards from a boundary of the OCHUS. The SHC includes a line flow slot extending from the wall to an apex of the OCHUS. The line flow slot receives and passes a fishing line from and to a spool. The securing mechanism is attachable to the SHC to rotatably secure the SHC to a fishing reel body. The rotatable line transfer mechanism is rotated about an axis of rotation of the spool in one direction to position the fishing line in a first end of the line flow slot during a retrieve mode, and in another direction to position the fishing line in a second end of the line flow slot during a cast mode.

Abstract: Techniques are provided for identity-based verification of software code layers. One method comprises obtaining, by a current layer of software code executing on a security processor of a security sub-system, in connection with a boot of the security sub-system, an identity key of the current layer, wherein the identity key of the current layer is based on a value generated during a provisioning of the security sub-system, wherein the value is based on a firmware image of at least one layer of the software code; obtaining an encrypted secure boot public key of a next layer; decrypting the encrypted secure boot public key of the next layer using the obtained identity key of the current layer; verifying the next layer using the decrypted secure boot public key of the next layer; and executing the next layer based at least in part on a result of the verifying.

Abstract: Provided is a method, performed by an augmented reality (AR) device, of measuring a user's vision. The method includes: obtaining, by using a camera of the AR device, a background image including an image of at least one physical object; identifying an edge of the image of the at least one physical object in the background image; determining a first region for measuring the vision of the user on the background image based on the edge of the image; determining a second region corresponding to the first region on a display of the AR device; outputting a virtual object for measuring the vision of the user to the second region; obtaining a user input signal for vision measurement after the outputting the virtual object; and determining a vision prescription value of the user based on the user input signal.

Abstract: Additive manufacturing's reliance on embedded computing renders it vulnerable to tampering through cyber-attacks. Sensor instrumentation of additive manufacturing devices allows for rigorous process and security monitoring, but also results in a massive volume of noisy data for each run. As such, in-situ, near-real-time anomaly detection is challenging. A probabilistic-model-based approach addresses this challenge.

Abstract: A distributed policy management (PM) system (e.g., system for authentication, authorization, and accounting (AAA) activities on a network) is provided. Nodes of the PM system may share information of the PM system using a distributed data store (e.g., a multi-master cache). Each node of the distributed PM system may further share information from the distributed data store with other nodes of a corporate infrastructure network by augmenting information in a remote authentication dial-in user service (RADIUS) protocol message. Nodes that are involved in policy management (e.g., network authentication server (NAS) or firewall) without access to the distributed data store may receive information via augmented RADIUS messages. In this manner, devices may be interfaced to the distributed PM system without having access to the distributed data store. High availability and load balancing implementations may be provided by leveraging the distributed data store across nodes of the PM system.

Abstract: A method is provided for vaporized hydrogen peroxide cleaning of a chamber. The method includes altering a temperature of air in the chamber from an initial temperature to a sterilization temperature over a first time period. The method also includes injecting vaporized hydrogen peroxide into air in the chamber to alter a relative humidity of hydrogen peroxide vapor in the chamber to a sterilization level over the first time period. The method also includes maintaining the temperature at the sterilization temperature and the relative humidity at the sterilization level over a second time period. The method also includes reducing the relative humidity from the sterilization level to a safe level over a third time period. In one embodiment, the method is provided for vaporized hydrogen peroxide cleaning of an interior chamber of an incubation container. In other embodiments, the incubation chamber featured in the method is provided.

Abstract: There is disclosed a method and system for executing commands. The method comprises configuring an input event topic subscriber and a command orchestrator process. The input event topic subscriber is invoked. The input event topic subscriber receives an event. The event comprises an event context and associated data. The event is transformed into a command. The command orchestrator is invoked. The command is input to the command orchestrator. The command orchestrator adds contextual information to the command. The command orchestrator schedules execution of the command. The execution of the command is tracked. A returned data object corresponding to the command is received and output.

Abstract: An orthopedic therapy apparatus is disclosed. The apparatus may include a deformable textile body having an adhesion surface and a non-adhesion surface opposite to the adhesion surface. The apparatus may further include a first adhesion pad surface and a second adhesion pad surface disposed on the adhesion surface. The apparatus may additionally include a tension member disposed between the first adhesion pad surface and the second adhesion pad surface. The tension member may be formed by folding a first adhesion surface side portion and a second adhesion surface side portion along a deformable textile body longitudinal axis to contact and adhere to a deformable textile body middle portion. The first adhesion surface side portion and the second adhesion surface side portion may be folded by using a plurality of separating cuts disposed on the deformable textile body.

Abstract: Disclosed is a pharmaceutical composition useful as an appetite suppressant. Disclosed also is a process for the suppression of appetite and/or for the treatment and/or prevention of obesity.

Abstract: An Emergency Vehicle Warning Indication system is provided. Disclosed herein are systems and methods for providing notification of emergency vehicles in advance of the approaching intersection further comprising one or more Control Modules or Modular Transmitters that receive and transmit a high secured radio frequency. This secured radio frequency may be further configured such that it is used only by Emergency Vehicles. The system and method further comprising a means for overriding the traffic signal sequence of the traffic signal system at the intersection. The system and method further comprising an emergency lighting system. Wherein the emergency lighting system may operate in conjunction with at least one of the traffic signal system, the emergency vehicle, and one or more Control Modules or Modular Transmitters.

Abstract: A support bracket assembly for supporting a pair of bushing well interrupter devices provided within a transformer enclosure that encloses a transformer. The support bracket assembly includes a mounting bracket assembly rigidly secured to a parking stand on the enclosure and including a plurality of mounting bosses. The support bracket assembly further includes support brackets, a first adjustable link secured to one of the mounting bosses on the mounting assembly and a mounting boss on a support bracket, a second adjustable link secured to another one of the mounting bosses on the mounting assembly and a mounting bosses on a support bracket, and a third adjustable link secured to mounting bosses on two support bracket, where the first, second and third adjustable links form a triangular configuration.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: A system is provided for use with an insulated boom section of a bucket truck. The system includes a source of high volume and pressure, dry air; one or more interior air diffusers connected to the source of high volume and pressure, dry air to direct the air into an interior of the insulated boom section. One or more exterior air diffusers connected to the source of high volume and pressure, dry air direct the air to along an exterior surface of the insulated boom section. A method is also provided for cleaning or drying both the interior and exterior surfaces simultaneously of an insulated boom section of the boom of a bucket truck. The boom of a bucket truck is further provided in another aspect that includes at least one insulated boom section, a source of high volume and pressure, dry air, one or more interior air diffusers and one or more exterior air diffusers. A pre-heating air heater may be removably mounted into the boom.

Abstract: A system and method for determining an open or closed position of a magnetically actuated vacuum interrupter. The method includes applying a voltage signal of a known voltage to the actuator over a predetermined period and determining a change in current over time during the period when the voltage signal is applied to the actuator using an output of a Rogowski coil. The method also includes calculating the inductance using the voltage and the change in current over time at a predetermined time during the period and using the calculated inductance to determine whether the actuator and thus the vacuum interrupter are in the open or closed position.

Abstract: Methods, systems, apparatuses, and computer program products for providing malware protection on a UAV are disclosed. In a particular embodiment, a method of providing malware protection on a UAV includes a malware defense controller initiating, on an unmanned aerial vehicle (UAV) in response to a malware defense event, a malware defense scan of at least one file stored on the UAV. In this embodiment, the malware defense controller also implements, in dependence upon a result of a malware detection analysis, a malware defense operation.

Abstract: Electric submersible pump and other centrifugal pump stages having non-axisymmetric components and passage contours are disclosed. Such a component can be a shrouded impeller having a non-axisymmetric profile for its hub and/or shroud.

Abstract: Provided is a pharmaceutical composition comprising an oral corticosteroid for use in post-exacerbation treatment of a respiratory disease in a subject, which post-exacerbation treatment includes an initial dose of the oral corticosteroid. The post-exacerbation treatment being continued until fulfilment of an inhalation parameter criterion by one or more post-exacerbation inhalations performed by the subject with at least one inhaler and/or fulfilment of a rescue inhaler usage criterion relating to post-exacerbation usage of a rescue inhaler configured to deliver a rescue medicament to the subject, at which point the dose of the oral corticosteroid is changed from the initial dose. Further provided are systems and methods for determining whether the inhalation parameter criterion is fulfilled and for comparing a post-exacerbation value of an inhalation parameter to a baseline value of the inhalation parameter.

Abstract: POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.

Abstract: The present invention relates to a portable testing device for checking power and ground of electrical circuits of automotive and marine vehicles, while obviating the need of a power probe or a meter. The device features a banana jack having a female connector and a test light having a strobe. A plurality of adapters including at least a back probing clip, a back piercing clip, and an alligator clip are provided with the device, wherein the female connector is configured to removably receive and accommodate an adapter. The strobe and the adapter attached to the banana jack are connected to a circuit and a ‘good’ circuit is indicated by illumination of an LED bulb disposed inside the test light. The device allows the users to easily test power and ground across two wires by either back probing using the back probing clip, or piercing using the back piercing clip.