Abstract: The present approach generally relates to systems and methods for implementing energy modulated tomographic imaging of nanoparticles. In certain embodiments, a first energy is used to activate probe particles labeling an anatomy or tissue of interest. The probe particles, once activated, emit photons at a different rate and/or spectrum in response to an underlying physiological event, such as action potentials propagating in the labeled anatomy or tissue. The emitted photons may then be detected and used to map or image the occurrence of the physiological event.

Abstract: The present approach generally relates to systems and methods for implementing energy modulated tomographic imaging of nanoparticles. In certain embodiments, a first energy is used to activate probe particles labeling an anatomy or tissue of interest. The probe particles, once activated, emit photons at a different rate and/or spectrum in response to an underlying physiological event, such as action potentials propagating in the labeled anatomy or tissue. The emitted photons may then be detected and used to map or image the occurrence of the physiological event.

Abstract: This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.

Abstract: Techniques, hardware, and software are provided for quantification of extensional features of structures of an imaged subject from image data representing a two-dimensional or three-dimensional image. In one embodiment, stenosis in a blood vessel may be quantified from volumetric image data of the blood vessel. A profile from a selected family of profiles is fit to selected image data. An estimate of cross sectional area of the blood vessel is generated based on the fit profile. Area values may be generated along a longitudinal axis of the vessel, and a one-dimensional profile fit to the generated area values. An objective quantification of stenosis in the vessel may be obtained from the area profile. In some cases, volumetric image data representing the imaged structure may be reformatted to facilitate the quantification, when the structural feature varies along a curvilinear axis. A mask is generated for the structural feature to be quantified based on the volumetric image data.

Abstract: This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event.

Abstract: A method and apparatus for providing a configurable field of view in a non-invasive imaging system, such as a CT medical imaging system. A detector structure comprising two or more flat-panel X-ray detectors is provided such that the configurable field of view may encompass the full area of the two or more X-ray detectors or any suitable subset of the full area. The field of view may be configured based upon an acceptable field of view in conjunction with an acceptable scan speed.

Abstract: A method for arranging detector sections for an imaging system that has a field of view that is defined by a rotational axis and imaging geometry is provided. The method includes providing a plurality of detector sections, and arranging the detector sections in an asymmetric arrangement about a central axis of the field of view.

Abstract: The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring.

Abstract: Techniques, hardware, and software are provided for quantification of extensional features of structures of an imaged subject from image data representing a two-dimensional or three-dimensional image. In one embodiment, stenosis in a blood vessel may be quantified from volumetric image data of the blood vessel. A profile from a selected family of profiles is fit to selected image data. An estimate of cross sectional area of the blood vessel is generated based on the fit profile. Area values may be generated along a longitudinal axis of the vessel, and a one-dimensional profile fit to the generated area values. An objective quantification of stenosis in the vessel may be obtained from the area profile. In some cases, volumetric image data representing the imaged structure may be reformatted to facilitate the quantification, when the structural feature varies along a curvilinear axis. A mask is generated for the structural feature to be quantified based on the volumetric image data.

Abstract: The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring.

Abstract: A method and apparatus for providing a configurable field of view in a non-invasive imaging system, such as a CT medical imaging system. A detector structure comprising two or more flat-panel X-ray detectors is provided such that the configurable field of view may encompass the full area of the two or more X-ray detectors or any suitable subset of the full area. The field of view may be configured based upon an acceptable field of view in conjunction with an acceptable scan speed.

Abstract: This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event.

Abstract: A method for arranging detector sections for an imaging system that has a field of view that is defined by a rotational axis and imaging geometry is provided. The method includes providing a plurality of detector sections, and arranging the detector sections in an asymmetric arrangement about a central axis of the field of view.

Abstract: An apparatus and method used to calibrate a gamma camera include an energy source and intensity selector and an energy weighting device. The energy source provides an energy output, such as an electrical current. The intensity selector is connected to the energy source and adjusts the energy output to a predetermined energy level that corresponds to an intensity of a predetermined radioactive source. The energy weighting device is also connected to the energy source and gamma camera, and the spatial compensator creates calibration signals from the energy output of the energy source. The calibration signals are supplied to the gamma camera and used during calibration of the gamma camera in lieu of energy signals produced by the gamma camera in response to a radioactive source.

Abstract: The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring.

Abstract: An x-ray imaging system images an object by transmitting primary signals and includes a collimator placed between detectors of the x-ray imaging system. The collimator reduces respective scatter components of total signals including a primary signal component and a scatter signal component. One of the detectors detects the total signals, the collimator collimates the primary signals of the total signals focally aligned with the collimator and traveling through the one of the detectors, another of the detectors detects the collimated, primary signals. The x-ray imaging system reduces the scatter components of the total signals detected by the one of the detectors based on the detected, collimated signals and the corresponding, detected, total signals. In another aspect, a detector includes regions of reduced absorption.

Abstract: A method and apparatus for use with a volumetric computed tomography (CT) scanning system. In accordance with the present invention, the volumetric CT scanning system utilizes an area detector to acquire projection data. The acquired projection data is stored in memory. The projection data corresponding to groups of pixels of the detector is then rebinned to thereby reduce the amount of projection data that will be utilized in performing an initial volumetric reconstruction of the image. The reconstructed image may then be processed to identify particular regions of interest, such as a pathology. If a particular region of interest is identified, all of the projection data corresponding to the region is then used to retrospectively reconstruct a high resolution image of the region of interest. The retrospectively reconstructed high resolution image can then be processed and analyzed to further evaluate the region of interest.

Abstract: A method and apparatus are provided which utilize a circular tomosynthesis system to collect 2-D x-ray projection radiograph data of an object being evaluated. The collected data is then transformed into a form suitable for cone beam volumetric computed tomography (cone beam VCT) reconstruction. Once the data has been transformed, a cone beam VCT reconstruction algorithm may be utilized to reconstruct a 3-D image of the object.

Abstract: A method of forming a planar semiconductor device, such as an array of APDs, includes the steps of doping a substantially planar block of n type semiconductor material with a p type dopant in accordance with a selected pattern to form a plurality of n type wells in the block surrounded by a foundation of p type semiconductor material. Each n type well is disposed so as to respectively adjoin a first surface of the block and such that a respective p-n junction is formed between the n type material in the well and the p type material foundation. The n type semiconductor material in each well has a substantially constant concentration of n type dopant throughout the n type material; the concentration of p type dopant in the foundation has a positive gradient extending from the p-n junction towards the second surface such that the peak surface electric field of the p-n junction in each well is less than the bulk electric field of the same p-n junction.

Abstract: An automated system for determining artifacts in images indicating defects in an imaging device being tested employs a constant radiation source which supplies radiation of spatially uniform intensity to the imaging device to be tested. The imaging device then creates a flood image A.sup.(0). A region of interest (ROI) mask means for all pixel values of flood image A.sup.(0) sets values to zero outside of the imaging devices field of view to produce a flood image A.sup.(1). An image normalization means normalizes flood image A.sup.(1) to have an average value of zero producing a normalized flood image A. A correlation means performs an autocorrelation of normalized flood image A to produce a correlation field which is then masked to select portions of the correlation field.