Abstract: This invention discloses methods and apparatus for providing a variable optic insert into an ophthalmic lens. A liquid crystal layer may be used to provide a variable optic function and in some examples, an alignment layer for the liquid crystal layer may be patterned in a cycloidally dependent manner. The patterning may allow for a polarization dependent lens in some examples. An energy source is capable of powering the variable optic insert included within the ophthalmic lens. In some examples, an ophthalmic lens is cast-molded from a silicone hydrogel. The various ophthalmic lens entities may include electroactive liquid crystal layers to electrically control optical characteristics.

Abstract: A control valve for a gas turbine engine air starter. The control valve includes a spherical or ball valve element rotatable between a closed position and an open position to connect an internal flow passage to the air starter. A series of camming elements interconnecting a piston and a valve stem for the spherical valve element convert linear displacement of the piston into rotational movement of the valve for rapid opening.

Abstract: A two part airless adhesive spray system is provided herein. This system provides numerous enhancements to the prior art including limiting overspray “fog,” saving on sprayed material because of a more efficient spray pattern, and providing a stronger bond than that of the air-atomized spray guns of the prior art.

Abstract: A device and a method for creating and/or maintaining an obstruction free upper respiratory passages. The device is configured to fit under the chin of a subject adjacent to the subject's neck at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The device is capable of exerting negative pressure on the surface of a subject's neck, displacing the soft tissue forward and enlarging the airway.

Abstract: In some examples, a medical device delivers electrical stimulation to the external portion of the globus pallidus of a brain of a patient in order to treat a sleep impairment of the patient. In some examples, the electrical stimulation may be delivered via one or more electrodes implanted in the GPe of the brain. In some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of a sleep state of a patient. The sleep state may include, for example, a state in which the patient is awake and intending on sleeping, is awake and attempting to sleep or has initiated sleep. In addition, in some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of an awake state of a patient.

Abstract: This document provides methods and materials involved obtaining induced pluripotent stem (iPS) cells. For example, methods and materials for increasing the efficiency for making iPS cells as well as methods and materials for selecting iPS cells are provided.

Abstract: Systems and methods for implementing and performing therapy-based workflows to assist a human user with performing health therapy activities are described. In various examples, therapy workflows involving the use of wearable or other personal electronic devices are described, including the use of various graphical user interfaces for assisting users with the performance of therapy activities. In an example, a computing device may evaluate profile characteristics of a human user, evaluate wearable sensor data originating from a wearable device worn by the human user, and obtain content from a content suggestion engine to be output during the therapy session based on the profile characteristics and the wearable sensor data. In further examples, the suggested activity content may be transmitted, displayed, and output to the human user in a graphical user interface during the therapy session, based on a duration and tinning determined by the content suggestion engine.

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

Abstract: Workflows can be refactored using a visual workflow model, such as within a virtual programming environment. A selection of a group of activities in an existing workflow can be received. The group of activities can be duplicated into a new workflow. Thereafter, the group of activities can be parsed to identify at least one input variable used by the activities of the group and at least one output variable resulting from those activities. The input variables and output variables are then duplicated as inputs and outputs to the new workflow. The previously selected group of activities can be replaced in the existing workflow with an activity based on the new workflow. The input variables and output variables are then mapped to the respective inputs and outputs of that activity.

Abstract: An aircraft humidifier is engineered as a stand-alone, fully integrated aircraft humidifier that is suitable for providing uniform, non-wetting humidified air disbursed by the aircraft humidifier into ambient air to increase the relative humidity in low humidity environments such as aircraft interiors, including cockpits, cabins, crew rests, cargo holds, and lavatories as well as any other enclosed areas.

Abstract: Some embodiments of the present disclosure are directed to methods, systems and probe devices for detecting EMG activity. In some embodiments, such methods, systems and devices are used in aiding the diagnosis of Obstruction Sleep Apnea (OSA). In some embodiments, a probe is provided and comprises an elongated member configured with a size and shape for placement adjacent at least one of the soft palate and pharyngeal wall of the patient after insertion of the probe into the patient. The probe may also include at least one sensor configured to sense at least EMG activity of muscle layers of at least one of the soft palate and pharyngeal wall and output sensor signals corresponding thereto. The signals may be monitored for EMG activity, and based on such activity, in some embodiments, a determination of whether the sensor signals of the detected EMG activity correspond to spontaneous EMG activity and/or abnormal motor unit potentials (MUPs).

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: A training sled apparatus, comprising: a platform with a rear edge and a wedge shaped front edge, opposite the rear edge of the platform; and, at least one sleeve provided to the platform and configured for placing a training component therein

Abstract: The present invention provides a system operable to collect customer ratings during a transaction using an electronic point of sale system comprising a computer programmed to effect operation of the electronic point of sale system.

Abstract: The present invention provides a pulp product (e.g., paper) comprising cellulose and nanocellulose, wherein the nanocellulose is derived from the cellulose in a mechanical and/or chemical step that is separate from the main pulping process. The pulping process may be thermomechanical pulping or hydrothermal-mechanical pulping, for example. The pulp product is stronger and smoother with the presence of the nanocellulose. The nanocellulose further can function as a retention aid, for a step of forming the pulp product (e.g., in a paper machine). Other embodiments provide a corrugated medium pulp composition comprising cellulose pulp and nanocellulose, wherein the nanocellulose includes cellulose nanofibrils and/or cellulose nanocrystals and the nanocellulose may be hydrophobic. The nanocellulose improves the strength properties of the corrugated medium. In some embodiments, the cellulose pulp is a GreenBox+® pulp and the nanocellulose is derived from the AVAP® process.

Abstract: There is disclosed a PIN entry device (PED) for electronic Point of Sale (EPOS) transactions. The PED has enhanced user I/O functionality but retains the strict security and certification framework of such a device. In addition to the usual PED functionality, the PED disclosed herein allows feedback from a user to be obtained in response to a question. The PED comprises an alphanumeric display for displaying text to a user, a numeric keypad and one or more function keys. The PED is configured to operate to display text to the user on the alphanumeric display to prompt a response from the user. The displayed text corresponds to approved text and unapproved text. The PED is configured to accept responses entered on the numeric keypad or one or more function keys in response to approved text, and to accept only a single key press response when prompted by a display of unapproved text. A corresponding method is also disclosed.

Abstract: Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel compositions to provide extruded hydrogel compositions, which can be crosslinked to provide crosslinked hydrogel structures. Also provided are methods for using crosslinked hydrogel structures in chemical processes.

Abstract: A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and generating visualization and executing models for communicating information.

Abstract: A method of forming a post of a cartridge of an electronic vaping device includes cutting a blank from a sheet of metal, drawing the blank to a desired diameter and length to form an elongate body, reverse drawing a portion of the elongate body to form a first end having an opening therein, the first end being generally cylindrical and having a generally beveled edge at an edge thereof, forming a bulged portion between the first end and a second end of the elongate body, and forming a flared section at the second end.

Abstract: An aircraft humidifier is engineered as a stand-alone, fully integrated aircraft humidifier that is suitable for providing uniform, non-wetting humidified air disbursed by the aircraft humidifier into ambient air to increase the relative humidity in low humidity environments such as aircraft interiors, including cockpits, cabins, crew rests, cargo holds, and lavatories as well as any other enclosed areas.