Patents by Inventor A. Oliver Sartor

A. Oliver Sartor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Saposin C and receptors as targets for treatment of benign and malignant disorders
    Patent number: 7166691
    Abstract: Saposin C was shown to be a trophic factor for a variety of cancer cells, e.g., prostate, lung, breast, and colon cancer cells. These cells expressed saposin C and responded to saposin C by increased levels of cell proliferation, cell migration, and cell invasion. Such activities typify and promote the neoplastic process. For prostate cancer, the androgen-insensitive prostate cancer cells responded to saposin C by higher levels of cell proliferation, cell migration and cell invasion than did the androgen-sensitive prostate cells. Stromal cells (from the prostate) were also responsive to saposin C-mediated signals in a manner typical of growth promoting compounds. The androgen-insensitive prostate cells were stimulated by saposin C to express higher levels of the urokinase plasminogen activator (uPA) and its receptor (uPAR), two proteins known to be involved in cell invasion.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: January 23, 2007
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Shahriar Koochekpour, A. Oliver Sartor
  • Saposin C and receptors as targets for treatment of benign and malignant disorders
    Publication number: 20040120961
    Abstract: Saposin C was shown to be a trophic factor for a variety of cancer cells, e.g., prostate, lung, breast, and colon cancer cells. These cells expressed saposin C and responded to saposin C by increased levels of cell proliferation, cell migration, and cell invasion. Such activities typify and promote the neoplastic process. For prostate cancer, the androgen-insensitive prostate cancer cells responded to saposin C by higher levels of cell proliferation, cell migration and cell invasion than did the androgen-sensitive prostate cells. Stromal cells (from the prostate) were also responsive to saposin C-mediated signals in a manner typical of growth promoting compounds. The androgen-insensitive prostate cells were stimulated by saposin C to express higher levels of the urokinase plasminogen activator (uPA) and its receptor (uPAR), two proteins known to be involved in cell invasion.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 24, 2004
    Inventors: Shahriar Koochekpour, A. Oliver Sartor