Abstract: A system for measurement is provided. The system includes a first optical path configured to supply first light pulses with a first range of wavelengths; a second optical path configured to supply second light pulses with a second range of wavelengths shorter than the first range of wavelengths; an optical I/O unit configured to emit the first light pulses and the second light pulses to a target and acquire a light from the target to detect CARS light pluses from the target by a detector; and a first phase modulating unit configured to vary phase differences between the first light pulses and the second light pulses as the first light pulses and the second light pulses are emitted via the optical I/O unit.

Abstract: Systems and methods for identifying and extracting specific product usage patterns of potential customers and utilizing a machine learning evaluation model to predict the potential customers that are most likely to convert their subscriptions.

Abstract: Improved techniques for secure access to cloud-based services via a gateway proxy. The improved techniques can efficiently manage remote access to cloud-based services by local processing agents in a secure manner using an intermediate authentication token issued by a gateway proxy to authorized local processing agents. The intermediate authentication token can be used to obtain authentication credentials of service providers that are needed to access the cloud-based services that are offered by service providers. In some embodiments, the authentication credentials of service providers need only be distributed to the gateway proxy and need not be distributed beyond the gateway proxy. The improved techniques are well suited for used with robotic process automation systems in which local processing agents, such as software agents, perform user tasks in an automated fashion.

Abstract: The present invention discloses a therapeutic composition comprising fusion protein with reduced heterogeneity in the glycosylation profile of the protein and methods thereof. More particularly the invention provides the composition with reduced heterogeneity in the glycosylation profile. By reducing heterogeneity, the resultant preparation is expected to exhibit superior, consistent results in terms of safety, purity and potency. The invention is of particular importance as it can form the part of the critical quality attributes (CQA) that help in ensuring batch-to-batch consistency and predicted shelf-life of complex protein molecules.

Abstract: A method for communicating with a device may include running, at a device, an operating system, communicating, using a first function of an interconnect, with the device, and communicating, using a second function of the interconnect, with the operating system. The operating system may include communication logic, and the communicating with the operating may include communicating with the communication logic. The communication logic may one or more terminal support drivers, and the communicating with the communication logic may include communicating with the one or more terminal support drivers using a terminal application. The terminal application may run on a host. The second function of the interconnect may be configured to operate with a controller. The communicating with the operating system may include communicating with the operating system based on a privilege information. The host may be a management controller.

Abstract: Methods of treating viral diseases are disclosed herein. Certain methods include diagnostic methods that quantify levels of biological features associated with TFH or CD4-CTL cells. Certain methods include treatment methods that affect the number, functionality, activity, or expression of TFH or CD4-CTL cells or TREG cells.

Abstract: This disclosure relates to shaker adjustments based on sensor measurements for sensors positioned at different locations about the shaker. This disclosure explains techniques to adjust a shale shaker as would be used to separate particulates (cuttings and other solids) from drilling fluid (commonly referred to as “mud”) during a drilling operation. Empirical models have been formulated to provide for programming a controller to calculate run-time adjustments to the shaker to increase efficiency. The controller may control one or more shakers concurrently. Different techniques and measurement types may be used concurrently to achieve desired shaker inclination and maintain a proper beach location during operation. Sensors include accelerometers, proximity sensors, and other types of data acquisition devices that may be used to detect motion parameters of an operational (e.g., in-use and running) shaker.

Abstract: A storage device is disclosed. The storage device may include storage to store data, which may include a first storage of a first type and a second storage of a second type. The storage device may support a number of device streams, some of which associated with the first storage and some associated with the second storage. The storage device may also include a streaming capabilities analyzer that may inventory the streaming capabilities for the storage device. Finally, the storage device may include a transmitter to transmit the streaming capabilities of the storage device to a storage manager.

Abstract: The present invention includes engineered T cell receptor (TCR) proteins, nucleic acids, vectors, host cells, methods of treating cancer, and chimeric antigen receptor expressing T cell (CAR-T) comprising an alpha chain CDR3 having the amino acid sequence of SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, or 23 and/or a beta chain CDR3 having the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24, wherein the TCR is specific for a KRAS G12>V mutation peptide, antigen-MHC binding portions, and full length portions of the same.

Abstract: Global transcriptional profiling of CTLs in tumors and adjacent non-tumor tissue from treatment-naïve patients with early stage lung cancer revealed molecular features associated with robustness of anti-tumor immune responses. Major differences in the transcriptional program of tumor-infiltrating CTLs were observed that are shared across tumor subtypes. Pathway analysis revealed enrichment of genes in cell cycle, T cell receptor (TCR) activation and co-stimulation pathways, indicating tumor-driven expansion of presumed tumor antigen-specific CTLs. Marked heterogeneity in the expression of molecules associated with TCR activation and immune checkpoints such as 4-1BB, PD1, TIM3, was also observed and their expression was positively correlated with the density of tumor-infiltrating CTLs.

Abstract: A programmable data storage device includes: a non-volatile memory; a storage controller configured to control the non-volatile memory; a network interface; and a field programmable gate array configured to: implement a blockchain algorithm; and store at least one block of a blockchain corresponding to the blockchain algorithm in the non-volatile memory via the storage controller; and a processor having memory coupled thereto, the memory having instructions stored thereon that, when executed by the processor, cause the processor to: send and receive one or more blocks of the blockchain via the network interface; and control the field programmable gate array to execute the blockchain algorithm on the one or more blocks of the blockchain.

Abstract: A method for communicating with a device may include running, at a device, an operating system, communicating, using a first function of an interconnect, with the device, and communicating, using a second function of the interconnect, with the operating system. The operating system may include communication logic, and the communicating with the operating may include communicating with the communication logic. The communication logic may one or more terminal support drivers, and the communicating with the communication logic may include communicating with the one or more terminal support drivers using a terminal application. The terminal application may run on a host. The second function of the interconnect may be configured to operate with a controller. The communicating with the operating system may include communicating with the operating system based on a privilege information. The host may be a management controller.

Abstract: A Solid State Drive (SSD) is disclosed. The SSD may include flash memory to store data. An SSD controller may manage reading and writing data to the flash memory. The SSD may include an automatic stream detection logic to select a stream identifier responsive to attributes of data. A garbage collection logic may select an erase block and program valid data in the erase block into a second block responsive to a stream ID determined the automatic stream detection logic. The stream ID may be determined after the garbage collection logic has selected the erase block for garbage collection.

Abstract: A programmable data storage device includes: a non-volatile memory; a storage controller configured to control the non-volatile memory; a network interface; and a field programmable gate array configured to: implement a blockchain algorithm; and store at least one block of a blockchain corresponding to the blockchain algorithm in the non-volatile memory via the storage controller; and a processor having memory coupled thereto, the memory having instructions stored thereon that, when executed by the processor, cause the processor to: send and receive one or more blocks of the blockchain via the network interface; and control the field programmable gate array to execute the blockchain algorithm on the one or more blocks of the blockchain.

Abstract: Disclosed herein are methods of detecting an antigen-specific T cell (e.g., a HDM-reactive T cell) expressing IL-9 which contribute to a worsening of an allergy (e.g., a HDM-induced allergy) or detecting an antigen-specific T cell (e.g., a HDM-reactive T cell) associated with a positive prognosis. In some embodiments, also disclosed herein is a method of treating an allergy (e.g., a HDM-induced allergy) in a subject in need thereof based on the presence or absence of an antigen-specific T cell (e.g., a HDM-reactive T cell) that express IL-9.

Abstract: Various embodiments described herein relate to providing and/or employing a knowledge graph related to one or more assets. In this regard, a request to generate knowledge graph data related to one or more assets is received. The request includes an asset descriptor describing the one or more assets. In response to the request, aggregated operational technology data is obtained based on the asset descriptor and from one or more data sources associated with the one or more assets. Furthermore, the aggregated operational technology data is contextualized, based on configuration data for the one or assets and a set of contextualization rules for the one or more data sources, to generate the knowledge graph data. The knowledge graph data is also allocated within a knowledge graph data structure configured for the one or more assets.

Abstract: Various embodiments described herein relate to an enterprise data management dashboard. In this regard, a request to generate a dashboard visualization related to one or more assets is received. The request includes an asset descriptor describing the one or more assets. In response to the request, aspects of aggregated operational technology data within a knowledge graph data structure are correlated to provide one or more insights associated with the one or more assets. Additionally, the dashboard visualization is provided to an electronic interface of a computing device. The dashboard visualization includes visualization data for the one or more insights associated with the knowledge graph data structure.

Abstract: Various embodiments described herein relate to an artificial intelligence system for integrity operating window optimization related to one or more assets. In this regard, a request to obtain one or more insights related to one or more assets is received. The request includes an asset descriptor describing the one or more assets. In response to the request, aspects of aggregated operational technology data within a knowledge graph data structure are correlated to provide the one or more insights. Additionally, one or more operational limits for the one or more assets are adjusted based on the one or more insights associated with the knowledge graph data structure.

Abstract: The present invention relates to an enzobiotic therapeutic combination, process for their preparation, enzobiotic therapeutical compositions containing them and their use as a therapeutic supplement or a nutritional supplement or a food supplement in renal diseases and disorders. The said combination comprising a therapeutically effective amount of: a) a synbiotic comprising at least one prebiotic and at least one probiotic and b) at least one proteolytic enzyme. The present invention further relates to kits and methods of using them. The enzobiotic combination and the enzobiotic composition comprising the said combination is particularly useful as a therapeutic supplement or a nutritional supplement or a food supplement to prevent generation of protein bound uremic toxins generated by undigested protein, to postpone dialysis and improve quality of life in subjects suffering from chronic kidney disease and end stage renal disease.

Abstract: A device of detecting a current from a sensor is disclosed. The device includes an integrating circuit including a network of capacitors for providing a gain setting and configured to convert the current to a voltage ramp over a length of integration time, the integrating circuit further including a reset switch configured to connect an input and an output of the network of capacitors; an ADC configured to digitize the voltage ramp into a plurality of voltage samples; and a set of modules including an analyzing module configured to analyze the plurality of voltage samples to determine a slope of the voltage ramp; an outputting module configured to determine a magnitude of the current based on the slope of the voltage ramp and the gain setting; and a reconfiguring module that is configured to reconfigure the network of capacitors and reset the voltage ramp via the reset switch.