Abstract: The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 34-36 respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 40-42 respectively. Monoclonal antibodies of the present invention can specifically bind to IL-17A, specifically antagonize the binding of IL-17A to a ligand thereof, and inhibit activation of fibroblasts by IL-17A.

Abstract: A non-puncturing microwave ablation antenna, including an irradiator located at a front end of the antenna and an irradiator cover sleeved on the irradiator, where a front end of the irradiator cover is blunt. Because the front end of the irradiator cover is designed to be blunt, the special non-puncturing appearance of the irradiator cover enables the antenna to freely penetrate inside the lung tissue without puncturing blood vessels and bronchi in the lungs. In addition, blood vessels of tumor existing in the Ground-Glass Opacity (GGO) would not be damaged by the blunt head and bleed, thereby reducing a rate of surgery failure caused by that a lesion cannot be identified because of bleeding inside the lung, and in addition, avoiding a possibility that tumor cells spread through a puncturing passage or bleeding blood vessels.

Abstract: The present disclosure relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine-1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acceptable salts thereof.

Abstract: A efficient large-scale selective laser melting forming device comprises a rack (1), a forming workbench (2) arranged on the rack, a forming bin (3) sleeved on the forming workbench and a galvanometer scanning device (7) arranged outside the forming bin and moving reciprocally along the powder spreading direction to form a multi-station working state, and a smoke blowing and sucking mechanism (8) arranged in the forming bin in a mode of synchronously moving to the same station with the galvanometer scanning device. The galvanometer scanning device can move reciprocally along the powder spreading direction to form a multi-station working state. The galvanometer scanning device is entirely arranged outside the forming bin. The smoke blowing and sucking mechanism arranged in the forming bin can synchronously move with the galvanometer scanning device to the same station.

Abstract: A Si-containing film forming composition comprising a catalyst and/or a polysilane and a N—H free, C-free, and Si-rich perhydropolysilazane having a molecular weight ranging from approximately 332 dalton to approximately 100,000 dalton and comprising N—H free repeating units having the formula [—N(SiH3)×(SiH2?)y], wherein x=0, 1, or 2 and y=0, 1, or 2 with x+y=2; and x=0, 1 or 2 and y=1, 2, or 3 with x+y=3. Also disclosed are synthesis methods and applications for using the same.

Abstract: The present invention relates generally to compositions and methods of killing biofilm using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). A method of killing biofilm may include contacting biofilm with a nanostructure (10) including a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16) to form a blend and exposing the blend to light.

Abstract: A voltage providing circuit includes a first voltage output end, a temperature-sensitive element, a power supply circuit and an output circuit. The power supply circuit is configured to apply a control voltage signal to a control end of the temperature-sensitive element. The temperature-sensitive element is configured to, under the control of the control voltage signal, generate a temperature-related voltage, and output the temperature-related voltage via a first end of the temperature-sensitive element, and a value of the temperature-related voltage changes along with an ambient temperature of the temperature-sensitive element. The output circuit is configured to output a temperature-adaptive voltage via the first voltage output end. A difference between a value of the temperature-adaptive voltage and the value of the temperature-related voltage is within a predetermined range.

Abstract: The present invention discloses a continuous high-power turbine fracturing equipment, including a turbine engine, a reduction gearbox, a and a plunger pump, the turbine engine is arranged coaxially with the reduction gearbox, the reduction gearbox is connected to the plunger pump through the transmission shaft, the angle between a central line of the reduction gearbox and the transmission shaft is between 2° and 4°.

Abstract: This application provides a data transmission method and an apparatus. The method includes: sending, by a first device, first indication information, where the first indication information is used to indicate a time-frequency resource of a first reference signal, and the first reference signal is used to perform channel estimation on retransmitted data of first data; and sending, by the first device, the retransmitted data.

Abstract: The present invention discloses a semi-trailer-loaded turbine fracturing equipment, which adopts a linear connection of the whole equipment and a special chassis design, so that the center of gravity is double lowered to guarantee its stability and safety, the structure is simpler, the investment and operation costs are decreased, the risk of total breakdown of the fracturing site is reduced, and the equipment has a good transmission performance and is suitable for continuous operation conditions with long time and heavy load.

Abstract: A Si-containing film forming composition comprising a catalyst and/or a polysilane and a N—H free, C-free, and Si-rich perhydropolysilazane having a molecular weight ranging from approximately 332 dalton to approximately 100,000 dalton and comprising N—H free repeating units having the formula [—N(SiH3)x(SiH2-)y], wherein x=0, 1, or 2 and y=0, 1, or 2 with x+y=2; and x=0, 1 or 2 and y=1, 2, or 3 with x+y=3. Also disclosed are synthesis methods and applications for using the same.

Abstract: The present invention discloses an air intake and exhaust system of a turbine engine, including an air intake system and an exhaust system. The air intake system is connected to an air inlet of the turbine engine, and the exhaust system is connected to an exhaust port of the turbine engine. The air intake system includes air intake filters and air intake pipings, which are connected to each other. The air intake filters are in V-shaped structures. The exhaust end of the exhaust system is provided with a rain cap. The beneficial effects are as follows: the air intake area is large, the flow rate of the air intake is relatively low, and the air filter has a long life time.

Abstract: This application provides a data transmission method, a terminal device, and a network device. The method includes: sending, by a terminal device, first information to a network device, where the first information is used to indicate a first channel quality indicator (CQI) corresponding to a first block error rate; and sending, by the terminal device, second information to the network device by using radio resource control (RRC) signaling or media access control (MAC) signaling, where the second information is used to indicate a difference between the first CQI and a second CQI, the second CQI is a CQI corresponding to a second block error rate, and the first block error rate is greater than the second block error rate.

Abstract: Systems and methods for automated systolic array design from a high-level program are disclosed. One implementation of a systolic array design supporting a convolutional neural network includes a two-dimensional array of reconfigurable processing elements arranged in rows and columns. Each processing element has an associated SIMD vector and is connected through a local connection to at least one other processing element. An input feature map buffer having a double buffer is configured to store input feature maps, and an interconnect system is configured to pass data to neighboring processing elements in accordance with a processing element scheduler. A CNN computation is mapped onto the two-dimensional array of reconfigurable processing elements using an automated system configured to determine suitable reconfigurable processing element parameters.

Abstract: The present disclosure relates to a signal processing system applied to remove OTDR noise, comprising: an analog-to-digital converter, a laser and driving unit, a sequence accumulator, a preprocessing counter, a pulse generator, a dual-port memory, a self-adaptive filter, an event decision device, and a preprocessing data decision device. The self-adaptive filter reads preprocessing data from a read-only port of the dual-port memory, and performs noise processing on the read preprocessing data by using a self-adaptive filtering method of wavelet transform. The event decision device performs an event decision on the filtered data output from the self-adaptive filter; The preprocessing data decision device decides whether a certain set of preprocessing data in m groups of preprocessing data is correct data or high-signal-to-noise data according to the difference of the m groups of preprocessing data after passing through the event decision device.

Abstract: A display device including a display panel and a backlight module are provided. The backlight module includes a backlight unit having a backlight hole; a light guide ring disposed inside the backlight hole, wherein the light guide ring comprises a light receiving surface provided away from the display panel and a light emitting surface provided near the display panel, and the light guide ring is configured to direct light beams to a display panel area corresponding to the backlight hole; and a light source component configured to provide a light source for the light guide ring.

Abstract: A backlight module and a liquid crystal display are provided. The backlight module realizes a narrow border of the backlight module by arranging a light source between a first protrusion portion of a support part and a light incident surface of a light guide plate. The backlight module cooperates with the liquid crystal display panel having a second protrusion portion and second notches of a stepped area, and a flexible printed circuit board passes through the second notches of the liquid crystal display panel and the first notches of the backlight module.

Abstract: A FFL-based magnetic particle imaging three-dimensional reconstruction method includes: acquiring current signal data of an induction coil during FFL-based three-dimensional scanning process of a scanned object; based on the current signal data, performing deconvolution through a preset kernel function to acquire a two-dimensional image data set, wherein the kernel function is a step function with L2 regularized constraint; based on the two-dimensional image data set, acquiring an initial three-dimensional image by using a Wiener filtering deconvolution algorithm; and based on the initial three-dimensional image, performing deconvolution through a Langevin function, and acquiring a final three-dimensional image by Radon transformation.

Abstract: The present disclosure provides a display panel and a fabricating method thereof. The display panel includes a substrate and a plurality of mutually insulated binding pads disposed on the substrate. Each binding pad includes an upper surface, a lower surface and a side surface. The upper surface and the lower surface are both parallel to a plane of the substrate, the side surface is located between the upper surface and the lower surface, and the side surface connects the upper surface with the lower surface. A first insulating layer is disposed on the side surface of the binding pad, the first insulating layer is in contact with the side surface of the binding pad and is made of an inorganic material. With such a configuration, the side surface of the binding pad will not be damaged by an etching process subsequent to fabrication of the binding pads.

Abstract: In a data transmission method, a terminal device receives control information, and receives data of a transport block (TB) on a first time-frequency resource; and the terminal devices obtains m code block (CB) groups in the TB, where m is a positive integer, m=min(NCB_re,NGroup_max), NCB_re is a quantity of CBs in the TB, NGroup_max is a maximum value of a quantity of CB groups, each of the m CB groups includes at least one CB, NCB_re is determined based on a TB size TBS and a maximum value of a data size of a CB, and the TBS is determined based on the control information.