Abstract: The present disclosure provides engineered cells (e.g., T cells) comprising a chimeric antigen receptor (CAR) and a therapeutic peptide, and methods of use thereof.

Abstract: A medical device is disclosed. The device may include a service component for use in detecting patient data, at least one processor coupled with the service component, a care protocol module executable by the at least one processor to provide healthcare to a patient at least in part by generating a request for processing by the service component, and a resource module executable by the at least one processor to manage access to the service component by identifying a level of service associated with the care protocol module and responding to the request by managing the service component to meet the level of service. The care protocol module implements a patient care protocol that includes a sequence of actions directed to the patient. The level of service indicates a level of performance that the patient care protocol requires of the resource module. Selective offloading of modular functions is also enabled.

Abstract: A method of transporting a vehicle engine wire harness from a component preparation location to a component pick location is provided. The method includes placing the vehicle engine wire harness on a hook of a component hanger. The component hanger with vehicle engine wire harness is directed along a supply track assembly through a heated enclosure to the component pick location at a vehicle assembly line.

Abstract: A utility vehicle is configured for off-road terrain and may include a plurality of mounting members configured to support a load and/or support the vehicle during transport. The utility vehicle also includes an upper frame assembly which is movable between a first position and second position. The upper frame assembly may be moved to the second position during transportation of the utility vehicle. Further, the utility vehicle includes a plurality of configurations for a rear cargo area, thereby allowing for passengers or cargo to be supported.

Abstract: Various exemplary methods and devices for actuating surgical instruments are provided. In general, a surgical device can include one or more actuation shafts configured to facilitate actuation of the device. In an exemplary embodiment, the device can include four actuation shafts, two actuation shafts to facilitate articulation of the device, one actuation shaft to facilitate opening and closing of jaws at a distal end of the device, and one actuation shaft to facilitate moving a cutting element of the device. In an exemplary embodiment, each of the one or more actuation shafts can include a distal elongate member and a proximal elongate member having a proximal end attached to a distal end of the distal elongate member. The proximal elongate member can be rigid, and the distal elongate member can be flexible.

Abstract: An automated trailer coupling arrangement includes a receiver member fixed to a towed vehicle and including pneumatic and electrical couplers, a shuttle member including pneumatic and electrical couplers, a control arm assembly supported on a towing vehicle and including a carrier member configured to operably couple and uncouple with the shuttle member, and an actuator coupled to the carrier member configured to move the carrier member between a first position where the carrier member is coupled with the shuttle member and the shuttle member is spaced from the receiver member, and a second position where the pneumatic and electrical couplers are respectively coupled and the carrier member is uncoupled and spaced from the shuttle member, wherein the control arm is configured to move a vertical and horizontal directions as the carrier member is moved between the first and second positions.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A method and a system for optimizing the alignment of an optical system, such as a telescope, using a multi-degree-of freedom (DOF) actuator/hexapod and star field images. The method iteratively adjusts the hexapod in all DOFs using the damped least squares (DLS) optimization algorithm and dynamically changes the size of pixel windows to measure ensquared energy (ES) as a closed loop feedback.

Abstract: A spatially sensitive augmented reality system for providing resuscitative feedback in a mixed reality environment to an acute care provider during occurrence of a cardiac event in a patient includes a wearable augmented reality device having at least one three-dimensional sensor, a visual display for viewing by the acute care provider, and at least one processor. The at least one processor is configured to receive and process three-dimensional information of a scene of the cardiac event; produce a three-dimensional representation of a field of view of the acute care provider based on the processed three-dimensional information; identify one or more physical objects associated with the cardiac event in the three-dimensional representation; generate at least one virtual three-dimensional object within the three-dimensional representation; and generate an image of the virtual three-dimensional object within the three-dimensional representation on the visual display.

Abstract: The technology described herein can generate a unique identifier for a visual media that comprises pre-printed visual indications on the visual media and a user's handwritten signature. The location of the signature on the visual media can be determined by including preprinted fiducial marks on the visual media. The fiducial markers act as landmarks that allow the size and location of the signature to be determined in absolute terms. The unique identifier is then stored in computer memory on a user-experience server. The user-experience server can associate the unique identifier with a digital asset, such as an image or video, designated by the user. When the unique identifier is provided to the user-experience server a second time, the digital asset can be retrieved and output to the computing device that provided the unique identifier.

Abstract: An automated trailer coupling arrangement includes a downwardly opening receiver member supported in a bottom surface of a towed vehicle at a first vertical height and including pneumatic/electrical couplers, a shuttle member including pneumatic/electrical couplers to couple to pneumatic and electrical supply sources and an arm pivotably coupled to a towing vehicle at a second vertical height that is less than the first vertical height and including a carrier member to operably couple/uncouple with the shuttle member, and an actuator coupled to the carrier member to move the carrier between a first position where the carrier member is coupled with the shuttle member and the shuttle member is spaced from the receiver member, and a second position where the pneumatic couplers and electrical couplers are respectively coupled with one another and the carrier is uncoupled and spaced from the shuttle member.

Abstract: Processes for imparting oil and grease resistance to paper products. In some embodiments, the process can include combining a plurality of fibers and water to produce a slurry; forming the slurry into a wet web; pressing and draining the wet web to produce a wet sheet; and drying the wet sheet to produce a dried sheet. A sizing composition and a barrier compound can independently be applied to at least one of the slurry, the wet web, the wet sheet, and the dried sheet. The sizing composition can include one or more alkenyl succinic anhydride compounds. The barrier compound can include a polyolefin dispersion, a styrene acrylate emulsion, a sucrose ester, a modified starch, styrene maleic anhydride, an ethylene acrylic acid dispersion, a styrene acrylic acid, a polyvinyl alcohol, an ethylene vinyl alcohol, or a mixture thereof. The dried sheet can have an average KIT Value of at least 3.

Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.

Abstract: Disclosed are methods for coating aluminum alloy heat exchangers that include the use of a waterborne top coating. By using a waterborne top coating, relative to a solvent borne, useful advantages can be achieved, such as improved penetration depth of the top coating. An example method includes cleaning a surface of a heat exchanger; contacting the surface of the heat exchanger with a first mixture to provide a passivation layer on the surface of the heat exchanger; contacting the passivation layer with a second mixture in a bath and applying a positive charge to the bath to provide an electro-coating on a surface of the passivation layer; and contacting the electro-coating with a third mixture, the third mixture including water and a polymer resin having anti-corrosion and ultraviolet protection properties, to provide a top coating including the polymer resin on a surface of the electro-coating.

Abstract: The instant disclosure is generally directed to low viscosity, low volatility lubricating compositions. The lubricating composition of the instant disclosure includes an oil of lubricating viscosity that contains a lubricating base oil and a hydrocarbon oil. The hydrocarbon oil makes up least 20 wt % of the oil of lubricating viscosity and has a kinematic viscosity of less than 3.7 c St at 100° C. and a NOACK volatility (measured by ASTM D5800) of less than 25 wt %. The lubricant composition further includes a polyalkenyl succinimide dispersant, and, optionally, other formulation additives. The lubricating compositions have been shown to increase fuel economy in internal combustion engines.

Abstract: The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

Abstract: Utility vehicles include ground engaging members, a frame supported by the ground engaging members, a motor supported by the frame operably coupled to the ground engaging members, and a battery configured to provide electrical power to the motor. The battery may be removable and configured to be easily charged by outside power sources such as generators and external batteries. A charger may be configured to receive instructions to charge the battery using a specific charger operating characteristic. The vehicle may also include a variety of accessory ports configured to electrically couple to accessories that use AC or DC power.