Abstract: A microtube for implant into the eye includes an elongated portion and a curved portion. The elongated portion extend along a longitudinal axis and includes a distal end opening of the microtube. The curved portion is contiguous with the elongated portion and includes a proximal end opening of the microtube and a plurality of sidewall openings between the proximal end opening and the elongated portion. The curved portion curves outward relative to the longitudinal axis and back towards the distal end of the microtube. A lumen extends through the elongated portion and the curved portion between the distal end opening and the proximal end opening and is in fluid communication with the sidewall openings.

Abstract: Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for regulating the activity of a Ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant Ras protein that is associated with the proliferative disease. Described herein is a modified Ras protein. Described herein are recombinant vectors, cells comprising the vectors expressing the modified Ras proteins. Provided herein is an antibody that specifically binds to a sumoylated Ras protein. Described herein is a method for identifying an agent that interferes with the sumoylation of a Ras protein. Also described herein are therapeutic and prophylactic compositions. Also provided herein is a method of using a modified Ras protein to replace an endogenous mutant Ras protein that is associated with a proliferative disease.

Abstract: The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a first nucleic acid construct comprising a first nucleic acid molecule encoding a first fusion protein comprising a peripheral cellular membrane binding protein or membrane binding domain thereof operatively coupled to DNA binding and transactivation domains of a naturally occurring or chimeric transcription factor and a first promoter operatively associated with the first nucleic acid molecule. A second nucleic acid construct comprises a second nucleic acid molecule encoding a reporter protein and a second promoter responsive to the DNA binding and transactivation domains of the first fusion protein. The second promoter is operatively associated with the second nucleic acid molecule. Activation of the second promoter results in expression of the reporter protein. Also disclosed is a transgenic non-human animal.

Abstract: In one embodiment, a method of constructing an equivalent waveform model for static timing analysis of integrated circuit designs is disclosed. The method includes fitting time point coefficients (qk) and known time delay values from a delay and slew model of a receiving gate from a timing library; determining waveform values (Ikj) for input waveforms from the timing library; determining timing values (dj) from a timing table in the timing library in response to the input waveforms of the timing library; and determining coefficients (qk) by minimizing a residual of a delay equation.

Abstract: A system for data exchange in multiprocessor computer system is disclosed. The system includes at least one processing module adapted to communicate with at least one of a plurality of routing modules or a plurality of buffer modules or both and at least one communicating interfaces to facilitate data exchange in multiprocessor computer system.

Abstract: The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a first nucleic acid construct comprising a first nucleic acid molecule encoding a first fusion protein comprising a peripheral cellular membrane binding protein or membrane binding domain thereof operatively coupled to DNA binding and transactivation domains of a naturally occurring or chimeric transcription factor and a first promoter operatively associated with the first nucleic acid molecule. A second nucleic acid construct comprises a second nucleic acid molecule encoding a reporter protein and a second promoter responsive to the DNA binding and transactivation domains of the first fusion protein. The second promoter is operatively associated with the second nucleic acid molecule. Activation of the second promoter results in expression of the reporter protein. Also disclosed is a transgenic non-human animal.

Abstract: A system for data exchange in multiprocessor computer system is disclosed. The system includes at least one processing module adapted to communicate with at least one of a plurality of routing modules or a plurality of buffer modules or both and at least one communicating interfaces to facilitate data exchange in multiprocessor computer system.

Abstract: The present invention relates to a method of identifying compounds as candidate drugs for treatment of cancer by providing a cell expressing a GTPase protein that is regulated by a prenyl-electrostatic switch, contacting the cell with compounds to be evaluated, and selecting compounds able to regulate charge at the prenyl-electrostatic switch in the GTPase protein as candidate drugs for treatment of cancer. Also disclosed are methods of treating cancer in a patient. An isolated antibody which binds to a phosphorylated prenyl-electrostatic switch on a K-Ras4B protein is also disclosed, as is a kit for detecting phosphorylation of a prenyl-electrostatic switch in a K-Ras4B protein which includes a labeled antibody and a device to detect the label. Also disclosed is a method of detecting phosphorylation of a prenyl-electrostatic switch on a K-Ras4B protein in a biological sample.

Abstract: A system for data exchange in multiprocessor computer system is disclosed. The system includes at least one processing module adapted to communicate with at least one of a plurality of routing modules or a plurality of buffer modules or both and at least one communicating interfaces to facilitate data exchange in multiprocessor computer system.

Abstract: A method of making an electrically conductive patterned film (74), such as an RFID antenna, is disclosed. The method includes the steps of providing a layer of conductive metal (24) adjacent a layer of release coating (20); providing a patterned adhesive layer (400) adjacent a target substrate (42); contacting the layer of conductive metal (24) and the patterned adhesive layer (40), such that a corresponding portion (70) of the layer of conductive metal (24) contacts the patterned adhesive layer (40); and the patterned adhesive layer (40) stripping the corresponding portion (70) of the layer of conductive metal (24) from the release coating (20). The patterned adhesive layer (40) can be formed in the shape of an RFID antenna. An electrical component or a computer chip (80) can be directly applied to the layer of conductive metal (24). An RFID device, such as an RFID tag or label is also disclosed.

Abstract: An electronic apparatus of the present invention has an electric fan in a casing. This electric fan generates air current between circuit substrates. The air current passes through the left-side gaps between the circuit substrates, and reaches the backside face of the electronic apparatus. The air current then passes through a power source substrate attached to a backside panel, and moves to the right. The air current then moves along the right-side inner surface and returns to the front side. The returned air is guided by a plurality of inner fins and then supplied to the electric fan. The heat generated in the casing is cooled by the air current circulating in the casing, and then conducted to the entire inner wall of the casing. The heat of the casing is then released into the atmospheric air through radiation fins arranged on the front face of the casing, the left and right side faces of the casing, and the front face of an open-close cover.

Abstract: An electronic apparatus of the present invention has an electric fan in a casing. This electric fan generates air current between circuit substrates. The air current passes through the left-side gaps between the circuit substrates, and reaches the backside face of the electronic apparatus. The air current then passes through a power source substrate attached to a backside panel, and moves to the right. The air current then moves along the right-side inner surface and returns to the front side. The returned air is guided by a plurality of inner fins and then supplied to the electric fan. The heat generated in the casing is cooled by the air current circulating in the casing, and then conducted to the entire inner wall of the casing. The heat of the casing is then released into the atmospheric air through radiation fins arranged on the front face of the casing, the left and right side faces of the casing, and the front face of an open-close cover.

Abstract: An antibody specific for the mammalian protein prenylcysteine carboxyl methyltransferase.

Abstract: The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with (derivatised) hydroxyalkyl substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising at least one of the 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds as the active ingredient.

Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.

Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.

Abstract: The present invention provides methods and for the dealcoholization of alcohol containing solutions, especially fermented beverages. In preferred embodiments the methods employ a novel controlled-strip evaporative perstraction technique following initial clarification to remove biomass, wherein strip solutions, dealcoholized beverage, or both are recycled for use in the strip solutions for dealcoholization of subsequent batches of feed beverage. In further preferred embodiments additives are introduced into the strip solution to further limit loss of volatile components during perstraction. Biomass removed by the clarification is then returned to the retentate product following perstration.

Abstract: A system is provided to treat wastewater from a metal-working facility, such as an automotive manufacturing plant in a bioreactor using live microorganisms. Such wastewater contains waste fluids which are a mixture of relatively easily biodegradable fats and oils, much less easily biodegradable synthetic fluids, oils and greases, and nonbiodegradable material including inorganic finely divided solids such as metal and silicon carbide particles. Such waste fluids require a hydraulic retention time (HRT) and a solids retention time (SRT) which is 10 times greater than for sewage. High quality water is separated from suspended solids which are removed from the reactor at an essentially constant rate and fed to an ultrafiltration membrane. Concentrate is recycled to the reactor, except for a bleed stream to remove solids periodically.

Abstract: A system to treat wastewater from a metal-working facility, such as an automotive manufacturing plant in a bioreactor using live microorganisms. Such wastewater contains waste fluids which are a mixture of relatively easily biodegradable fats and oils, much less easily biodegradable synthetic fluids, oils and greases, and non-biodegradable material including inorganic finely divided solids such as metal and silicon carbide particles. Such waste fluids require a hydraulic retention time (HRT) and a solids retention time (SRT) which is 10 times greater than for sewage. High quality water is separated from suspended solids which are removed from the reactor at an essentially constant rate and fed to an ultrafiltration membrane. Concentrate is recycled to the reactor, except for a bleed stream to remove solids periodically.