Patents by Inventor A. Rajamannan

A. Rajamannan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210095049
    Abstract: A method for inhibiting ectopic calcification of bodily organs caused by elevated LDL cholesterol is provided. The method includes administering an LDL lowering agent to a patient, comprising a PCSK9 inhibitor selected from Evolocumab, Alirocumab, Praluent, Repatha Pushtonix, Repatha autoinjector, and combinations of the foregoing.
    Type: Application
    Filed: May 18, 2020
    Publication date: April 1, 2021
    Inventor: Nalini M. Rajamannan
  • Patent number: 10729811
    Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 4, 2020
    Assignee: CONCIEVALVE, LLC
    Inventor: Nalini M. Rajamannan
  • Publication number: 20190321515
    Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 24, 2019
    Applicant: CONCIEVALVE LLC
    Inventor: Nalini M. Rajamannan
  • Publication number: 20190218306
    Abstract: A method for inhibiting ectopic calcification of bodily organs caused by elevated LDL cholesterol is provided. The method includes administering an LDL lowering agent to a patient, comprising a PCSK9 inhibitor selected from Evolocumab, Alirocumab, Praluent, Repatha Pushtonix, Repatha autoinjector, and combinations of the foregoing.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 18, 2019
    Inventor: Nalini M. Rajamannan
  • Publication number: 20180280573
    Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventor: Nalini M. Rajamannan
  • Patent number: 10058630
    Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: August 28, 2018
    Assignee: CONCIEVALVE, LLC
    Inventor: Nalini M. Rajamannan
  • Publication number: 20180140747
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis or a native valve which develops disease via the Lrp5/Wnt Pathway in the presence of elevated lipids due to elevated Low Density Lipoprotein. This invention involves dispensing a combination of medications to target inflammation and attachment of the target cell and the secondary drugs to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet. The combination therapy inhibits bioprosthesis and native valve calcification with improvement of the longevity of the prosthetic material including the stent, the native valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is connected to the valve.
    Type: Application
    Filed: April 15, 2016
    Publication date: May 24, 2018
    Applicant: CONCIEVALVE LLC
    Inventor: Nalini M. Rajamannan
  • Publication number: 20170304497
    Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 26, 2017
    Inventor: Nalini M. Rajamannan
  • Publication number: 20160303287
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition on an elastical stent or valve leaflet. The valve prosthesis is mounted on the elastical stent such that the elastical stent is in contact with the valve.
    Type: Application
    Filed: June 27, 2016
    Publication date: October 20, 2016
    Inventor: Nalini Marie Rajamannan
  • Publication number: 20160279297
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition which is a combination of two different drugs one to target inflammation and attachment of the target cell and the second drug to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet, the combination effect of the two drug therapies incorporated into the polymer to attach to the bioprosthesis will improve the efficacy of the inhibition of calcification and the improvement of the longevity of the prosthetic material including the stent, the valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is in contact with the valve.
    Type: Application
    Filed: October 22, 2014
    Publication date: September 29, 2016
    Applicant: Concievalve LLc
    Inventor: Nalini M. Rajamannan
  • Publication number: 20150306281
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis or a native valve which develops disease via the Lrp5/Wnt Pathway in the presence of elevated lipids due to elevated Low Density Lipoprotein. This invention involves dispensing a combination of medications to target inflammation and attachment of the target cell and the secondary drugs to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet. The combination therapy inhibits bioprosthesis and native valve calcification with improvement of the longevity of the prosthetic material including the stent, the native valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is connected to the valve.
    Type: Application
    Filed: April 15, 2015
    Publication date: October 29, 2015
    Inventor: Nalini Marie Rajamannan
  • Patent number: 9144202
    Abstract: Methods of treating agricultural fruit crops of the genus Musa having a mother plant and an adjoined offspring, or daughter plant, involve implanting at least one nutrient component into a pseudo stem of the mother plant after harvesting fruit from the mother plant. The nutrients implanted into the pseudo stem of the mother plant after harvesting are then available to the daughter plant more efficiently than nutrients applied to the soil.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: September 29, 2015
    Assignee: Agro-K Corporation
    Inventor: A. Harry J. Rajamannan
  • Publication number: 20140257473
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition on an elastical stent or valve leaflet. The valve prosthesis is mounted on the elastical stent such that the elastical stent is in contact with the valve.
    Type: Application
    Filed: April 28, 2014
    Publication date: September 11, 2014
    Inventor: Nalini Marie Rajamannan
  • Publication number: 20140114407
    Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition on an elastical stent and securing the valve prosthesis which may have a collapsible elastical valve mounted on the elastical stent such that the elastical stent may be in contact with the valve.
    Type: Application
    Filed: October 22, 2012
    Publication date: April 24, 2014
    Applicant: ConcieValve LLC
    Inventor: Nalini Marie Rajamannan
  • Patent number: 8003570
    Abstract: A composition for and a method to kill nematodes, weeds, weed seeds and weed rhizomes in soils.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: August 23, 2011
    Assignee: Agro-K Corporation
    Inventor: A. Harry J. Rajamannan
  • Publication number: 20110000129
    Abstract: Methods of treating agricultural fruit crops of the genus Musa having a mother plant and an adjoined offspring, or daughter plant, involve implanting at least one nutrient component into a pseudo stem of the mother plant after harvesting fruit from the mother plant. The nutrients implanted into the pseudo stem of the mother plant after harvesting are then available to the daughter plant more efficiently than nutrients applied to the soil.
    Type: Application
    Filed: July 1, 2009
    Publication date: January 6, 2011
    Inventor: A. Harry J. Rajamannan
  • Publication number: 20080300184
    Abstract: Materials and Methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
    Type: Application
    Filed: October 5, 2007
    Publication date: December 4, 2008
    Inventors: Thomas C. Spelsberg, Malayannan Subramaniam, Merry Jo Velasquez, Nalini M. Rajamannan
  • Publication number: 20080090730
    Abstract: A composition for and a method to kill nematodes, weeds, weed seeds and weed rhizomes in soils.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 17, 2008
    Inventor: A. Harry J. Rajamannan
  • Patent number: 7304203
    Abstract: Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: December 4, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Thomas C. Spelsberg, Malayannan Subramaniam, Merry Jo Velasquez, Nalini M. Rajamannan
  • Publication number: 20070142227
    Abstract: A systemic inducer comprising a chemical compound combined with microorganismic substance extracted from non-plant pathogenic microorganisms. The compound includes an acid and/or the salt of phosphorus, potassium, calcium, sodium, magnesium, manganese, zinc, copper and iron. The microorganismic substance may be extracted from fungus, bacteria or virus. The systemic inducer may be applied to stems, leaves, seeds, flowers or fruits of plants. Alternatively, the systemic inducer may be applied to soil to elicit a response via the roots of the plants. Finally, the systemic inducer may be injected into the stem or pseudo stem of the plants. The inducer effectively enables the induced plants to resist attack by pathogens to plants, seedlings, leaves, fruits, flowers and roots.
    Type: Application
    Filed: December 9, 2005
    Publication date: June 21, 2007
    Inventor: A. Rajamannan