Abstract: The present invention relates to a novel naphthyridinone derivative compound, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, which are each relevant to a compound for inhibiting ENPP1, a composition for inhibiting ENPP1, and a method for inhibiting ENPP1.

Abstract: The present invention relates to a novel chimeric antigen receptor comprising a CD99 region which participates in immune synapse stabilization as a backbone of the chimeric antigen receptor, an immune cell comprising the same, and the uses thereof. CD99-based CAR-T cells are capable of forming very stable immune synapses with tumor cells compared to conventional backbone-based CAR-T cells and can exhibit improved tumor therapeutic efficiency, so they can be useful for immune cell therapy for the treatment of cancer.

Abstract: This disclosure relates to a stretchable composite electrode and a fabricating method thereof, and particularly relates to a stretchable composite electrode including a silver nanowire layer and a flexible polymer film and a fabricating method thereof.

Abstract: The present invention relates to a novel benzotriazole derivative compound, a tautomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, which are related to a compound for inhibiting ENPP1, a composition for inhibiting ENPP1, and a method for inhibiting ENPP1.

Abstract: The present invention relates to a liver-specific drug delivery carrier comprising a nucleic acid nanoparticle and cholesterol; a liver-specific complex; a pharmaceutical composition for prevention or treatment of liver disease using the same; and a method for preventing or treating liver disease.

Abstract: A frame structure for a vehicle includes: an inner panel connected to a side member and defining an inner side of a rear part of the side member; an outer panel connected to a rear side of the side member and coupled to an outer side of the inner panel defining a closed cross-section together with the inner panel and defining an outer side of the rear part of the side member; an opening portion formed below the inner and outer panels partially opening the closed cross-section so that a front end of a rear suspension arm can be inserted into the opening portion; and a reinforcing member disposed in the opening portion defining the closed cross-section together with the outer panel and the inner panel and configured to close an internal space in the outer and inner panels.

Abstract: Systems, methods, and computer-readable media are disclosed for estimating impressions for a digital out of home (DOOH) advertising spaces (e.g., digital billboards and screens). A DOOH advertising system may determine the location of relevant DOOH advertising spaces and the location of certain consumers with known attributes and a known location. Based on this information the DOOH advertising system may estimate a number of impressions for a given DOOH advertising space and a given consumer segment associated with attributes of consumers within a certain distance from the DOOH advertising space. Using this information, the DOOH advertising spaces having the highest estimated impressions for a given consumer segment may be identified.

Abstract: A display device includes: a first substrate including a first area, a second area surrounding the first area, and a third area surrounding the second area; a second substrate facing the first substrate; a sealing member between the first substrate and the second substrate at the third area; a color filter layer under the second substrate; a low refractive index layer under the color filter layer, overlapping with the first area, and spaced from the sealing member; a protective layer covering the low refractive index layer, surrounding a side surface of the low refractive index layer, and including an inorganic material; and a color conversion layer under the protective layer, overlapping with the first area, and including a plurality of color conversion parts spaced from each other.

Abstract: A voice control method and display apparatus are provided. The voice control method includes converting a voice of a user into text in response to the voice being input during a voice input mode; performing a control operation corresponding to the text; determining whether speech of the user has finished based on a result of the performing the control operation; awaiting input of a subsequent voice of the user during a predetermined standby time in response to determining that the speech of the user has not finished; and releasing the voice input mode in response to determining that the speech of the user has finished.

Abstract: A voice control method and display apparatus are provided. The voice control method includes converting a voice of a user into text in response to the voice being input during a voice input mode; performing a control operation corresponding to the text; determining whether speech of the user has finished based on a result of the performing the control operation; awaiting input of a subsequent voice of the user during a predetermined standby time in response to determining that the speech of the user has not finished; and releasing the voice input mode in response to determining that the speech of the user has finished.

Abstract: A fusion protein includes heat shock protein 10 and brazzein protein. The fusion protein has an enhanced anti-oxidation activity and skin cell proliferation effect. It can be used as a cosmetic composition for ameliorating skin wrinkles. The cosmetic composition including the fusion protein can be advantageously used in future as a material of a functional cosmetic product.

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additionally, the present invention provides novel intermediates useful for said process and processes for preparing the same.

Abstract: Provided herein are methods for increasing the level of mogrosides in plants, such as in Cucurbitaceae family plants (e.g., in watermelon), by genetically-modifying such plants to modulate the expression of endogenous mogroside pathway genes. Also disclosed herein are plants with increased levels of mogrosides, extract (e.g., sweetener) from such plants, parts (e.g., juice, seed, pulp, etc.) from such plants, and methods of producing such plants.

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.

Abstract: The present disclosure in some embodiments provides a dialogue state tracking method and a dialogue state tracking apparatus in a goal-oriented dialogue system, which track a dialogue state through training based on an attention mechanism between utterances and contextual semantic vectors corresponding respectively to domain-slot types and based on a distance metric-based non-parametric method and thereby facilitate service extension to a multi-domain scenario in the dialogue system.

Abstract: A fusion protein includes heat shock protein 10 and brazzein protein. The fusion protein has an enhanced anti-oxidation activity and skin cell proliferation effect. It can be used as a cosmetic composition for ameliorating skin wrinkles. The cosmetic composition including the fusion protein can be advantageously used in future as a material of a functional cosmetic product.

Abstract: A semiconductor memory device includes a substrate including cell and peripheral regions, a cell gate electrode disposed at the cell region, a bit line structure disposed at the cell region and including a cell conductive line and a cell line capping film disposed thereon, fin-type patterns disposed at the peripheral region, a peripheral gate electrode crossing the fin-type patterns, a peripheral gate separation pattern disposed on a sidewall of the peripheral gate electrode and having an upper surface higher than an upper surface of the peripheral gate electrode, and a peripheral interlayer insulating film covering the peripheral gate electrode, the peripheral gate separation pattern and a portion of a sidewall of the peripheral gate separation pattern. An upper surface of the peripheral interlayer insulating film and an uppermost surface of the cell line capping film are positioned at the same height relative to the substrate.

Abstract: Disclosed is a method for preparing bio-oil, which can be used as bio heavy fuel oil and bio marine oil, from a fatty acid with high acid value.

Abstract: The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.

Abstract: The present disclosure in some embodiments provides a dialogue state tracking method and a dialogue state tracking apparatus in a goal-oriented dialogue system, which track a dialogue state through training based on an attention mechanism between utterances and contextual semantic vectors corresponding respectively to domain-slot types and based on a distance metric-based non-parametric method and thereby facilitate service extension to a multi-domain scenario in the dialogue system.