Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A system includes at least one hardware processor in communication with a user computing device associated with a user and a memory storing instructions. When executed by the at least one hardware processor, the instructions cause the at least one hardware processor to perform operations including receiving gaming behavior data associated with the user playing a computer game on the user computing device, the gaming behavior data includes one or more of session-based behavior data, game-selection behavior data, and ancillary gaming behavior data, determining a first trait of the user based on the gaming behavior data, and automatically computing a financial risk factor associated with the user based on the determined first trait.

Abstract: Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.

Abstract: Systems and methods for automatically processing prescription refills and transfers are disclosed. According to certain aspects, a server associated with a pharmacy may receive, from an electronic device, a message including a digital image depicting a container of a prescription. The server may analyze the digital image to identify a set of visual identifiers depicted in the digital image. Based on the set of visual identifiers, the server may determine whether the prescription is associated with the pharmacy and, based on the determination, may facilitate either a refill of the prescription or a transfer of the prescription to the pharmacy.

Abstract: Aspects provide for a circuit including a voltage supply, a driver, and a feedback bias circuit. The driver includes a first p-type field effect transistor (FET) and a first n-type FET. The voltage supply has an input and an output. The driver has a first input coupled to the voltage supply output, a second input coupled to a first node, and an output coupled to a second node. The first p-type FET has a gate coupled to the output of the driver, a source coupled to the voltage supply output, and a drain coupled to the second node. The first n-type FET has a gate coupled to the output of the second driver, a drain coupled to the second node, and a source coupled to a ground node. The feedback bias circuit has an input coupled to the second node and an output coupled to the voltage supply input.

Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

Abstract: Apparatus and processes herein provide for converting hydrocarbon feeds to light olefins and other hydrocarbons. The processes and apparatus include, in some embodiments, feeding a hydrocarbon, a first catalyst and a second catalyst to a reactor, wherein the first catalyst has a smaller average particle size and is less dense than the second catalyst. A first portion of the second catalyst may be recovered as a bottoms product from the reactor, and a cracked hydrocarbon effluent, a second portion of the second catalyst, and the first catalyst may be recovered as an overhead product from the reactor. The second portion of the second catalyst may be separated from the overhead product, providing a first stream comprising the first catalyst and the hydrocarbon effluent and a second stream comprising the separated second catalyst, allowing return of the separated second catalyst in the second stream to the reactor.

Abstract: Disclosed within are a structure and method for forming a component for a rotor to be used in an electric machine. The formed rotor components can include a rotor assembly or rotor shaft. The rotor assembly can include a plurality of poles spaced about a rotor core. The plurality of poles can include a pole shoe or pole body. Quasi-laminations that can result in a unitary structure that includes support structures can be used to form all or a portion of the pole shoe or pole body.

Abstract: A combustion tube assembly of a water heater includes a combustion tube having an open end, a closed end, and an outflow opening located between the open end and the closed end. A cavity of the combustion tube provides a chamber for a combustion of a water heater fuel that produces an exhaust gas that flows down toward the closed end. The combustion tube assembly further includes a diverter structure positioned inside the combustion tube to divert the exhaust gas such that the exhaust gas flows toward the closed end on a first side of the diverter structure and flows from the first side of the diverter structure to the second side of the diverter structure through a flow opening proximal to the closed end. The outflow opening provides an outlet for the exhaust gas that flows to the second side of the diverter structure to exit the combustion tube.

Abstract: A method, article of manufacture, and apparatus for processing data. In some embodiments, this includes analyzing a first container at a block level, determining a first level of granularity based on the analysis of the first container, based on the first level of granularity, identifying a first set of data objects, storing metadata of the first set of data objects in a recovery catalog, based on the first set of data objects, identifying a second container, analyzing the second container at a block level, determining a second level of granularity based on the analysis of the second container, based on the second level of granularity, identifying a second set of data objects, storing metadata of the second set of data objects in the recovery catalog, wherein the recovery catalog is stored in a storage device.

Abstract: A blockchain-based rough gemstone planning method including receiving a gemstone record including gemstone scan information and a smart contract, receiving a plurality of virtual derivative gemstones that may be derived from a gemstone associated with the received gemstone record and a plurality of virtual derivative gemstone records comprising meta-information about the virtual derivative gemstones, recording the plurality of virtual derivative gemstone records to a meta-information database, generating a plurality of derivative smart contracts associated with the plurality of virtual derivative gemstone records, sending the virtual derivative gemstone records and the derivative smart contracts, receiving price information for the plurality of virtual derivative gemstone records, and identifying a subset of the plurality of virtual derivative gemstone records that may be derived from the gemstone associated with received gemstone record responsive to the received price information received.

Abstract: The present disclosure describes systems, methods, and non-transitory computer readable media for generating lookalike segments corresponding to a target segment using decision trees and providing a graphical user interface comprising nodes representing such lookalike segments. Upon receiving an indication of a target segment, for instance, the disclosed systems can generate a lookalike segment from a set of users by partitioning the set of users according to one or more dimensions based on probabilities of subsets of users matching the target segment. By partitioning subsets of users within a node tree, the disclosed systems can identify different subsets of users partitioned according to different dimensions from the set of users. The disclosed systems can further provide a node tree interface comprising a node for the set of users and nodes for subsets of users within one or more lookalike segments.

Abstract: A mechanism is provided to implement a personally identifiable information (PII) detection mechanism that facilitates privacy protection utilizing template embedding learned from text sequences. Input text is processed using natural language processing to identify one or more pieces of personally identifiable information. A character analysis is performed of each character of each piece of personally identifiable information of the one or more pieces of personally identifiable information to identify a character type of character in the piece of personally identifiable information. For each piece of personally identifiable information and based on the associated identified character type, the identified character type is mapped to an associated template character in a set of template characters in a template character data structure.

Abstract: According to an embodiment of the present disclosure, in a terminal, in addition to event information in the ONVIF format, information for determining rotation and information about a cropped region cropped from an original region are additionally transmitted.

Abstract: Uses of a dual V region antibody-like protein or a fragment of a dual V region antibody-like region.

Abstract: An information handling system includes a processor, a graphics processing unit (GPU), and a baseboard management controller (BMC). The BMC includes a power ratio table with a plurality of entries, each correlating a workload with a power ratio of a power level of the processor when the particular workload is instantiated on the information handing system to a power level of the GPU when the particular workload is instantiated on the information handling system. The BMC determines that the power ratio table includes an entry associated with a workload instantiated on the information handling system, determines that a total power level of the information handling system is greater than a power level threshold, and throttles a power level of the processor and a power level of the GPU based upon a power ratio of the entry in response to determining that the total power level is greater than the power level threshold.

Abstract: An air conditioner includes a housing including an indoor cavity and an outdoor cavity spaced apart from and communicating with each other, an indoor unit assembly provided in the indoor cavity, and an outdoor unit assembly connected to the indoor unit assembly and provided in the outdoor cavity. A part of a bottom wall of the housing is recessed towards an inner cavity of the housing to form a mounting groove and penetrating opposite side walls of the housing. The mounting groove is located between the indoor cavity and the outdoor cavity.

Abstract: An electronic shelf label and a method for assembling the same. The electronic shelf label including: a housing (10), the housing including a front housing (12) and a rear housing (11), the front housing (12) and the rear housing (11) being coupled with each other, a chamber (13) being provided between the front housing (12) and the rear housing (11), the rear housing (11) including an opening (111); a motherboard (31), the motherboard (31) being located in the chamber; a back plate (32), the back plate (32) covering the opening (111), the motherboard (31) being detachably coupled to the back plate (32), the back plate (32) being detachably coupled to the rear housing (11), and an orthographic projection of the back plate (32) in a plane where the rear housing (11) is located being located in the rear housing (11).

Abstract: A regen node is described. The regen node includes a coherent receiver, a control module and a coherent transmitter. The coherent receiver has circuitry to convert a first optical signal received from an upstream node in an optical layer of an optical network to a first digital data stream in a digital layer having a first FEC frame and a data traffic. The control module extracts a first fault signal from the first FEC frame; generates a second fault signal based at least in part on the first fault signal; and encodes the second fault signal within a second FEC frame with the data traffic into a second digital data stream on the digital layer. The coherent transmitter has circuitry to convert the second digital data stream into a second optical signal on the optical layer and to transmit the second optical signal to a downstream node.