Abstract: Improved process for the preparation of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide of formula (I) and its intermediates is provided.

Abstract: The invention relates to improved processes for the preparation of bosentan monohydrate which provide higher yield and purity.

Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

Abstract: The present invention relates to a low sodium salt composition and the methods used to make it. In particular, the invention relates to the combined processing of sodium and potassium chloride to produce a low sodium salt composition. The low sodium salt composition includes sodium chloride and a modified chloride salt composition. The modified chloride salt composition includes a homogenous amalgamation of chloride salts, food grade acidulant, and carrier.

Abstract: In one embodiment, a layer-2 network that includes a cloud switch is partitioned into a plurality of segments, each segment including one or more cloud switch domains that are coupled via a logical port to a corresponding one of a plurality of internal logical shared media links. One of the internal logical shared media links is provisioned as a hub. One or more remaining internal logical shared media links are defaulted to be spokes. A spanning tree protocol (STP) is executed within each segment. The logical port of each cloud switch domain advertises a pseudo root bridge identifier (ID) to cause the internal logical shared media link to appear attached to a Root. The advertised pseudo root bridge ID of the hub is chosen to have a higher priority than the pseudo root bridge ID of the spokes to establish a hub and spoke relationship among the segments.

Abstract: The present invention provides a novel crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical compositions comprising it.

Abstract: The present invention provides a commercially viable process for preparing pazopanib and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate. The present invention also provides a process for the purification of pazopanib hydrochloride.

Abstract: Mechanisms are provided for performing efficient compression and deduplication of data segments. Compression algorithms are learning algorithms that perform better when data segments are large. Deduplication algorithms, however, perform better when data segments are small, as more duplicate small segments are likely to exist. As an optimizer is processing and storing data segments, the optimizer applies the same compression context to compress multiple individual deduplicated data segments as though they are one segment. By compressing deduplicated data segments together within the same context, data reduction can be improved for both deduplication and compression. Mechanisms are applied to compensate for possible performance degradation.

Abstract: Apparatus and method for wireless communication in a wireless communication network include operating a wireless device on a first wireless communication technology and detecting a first cell in first frequency of a second wireless communication technology. The aspects also include determining the detected cell of the second wireless communication technology satisfies a first reselection criterion based on a first measurement and identifying a second frequency of the second wireless communication technology as an undetected frequency based on monitoring the second frequency without detecting a second cell. Aspects also include expediting a determination of whether to perform cell reselection to the second wireless communication technology based on the undetected frequency and the detected cell of the second wireless communication technology satisfying the first reselection criterion and determining to reselect to the detected cell of the second wireless communication technology.

Abstract: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.

Abstract: Pre-authorized communication services and/or transactions are provided via a plurality of networks in response to a request received from a user to provide at least one of a communication service, a transaction and user account information via a plurality of networks of different types. Prior to processing the request, there is verification of the user's authorization to receive the at least one of the communication service, the transaction, and the user account information, and that an account associated with the user has a sufficient amount currently available for payment of the at least one of the communication service and the transaction. After verification, an authorized account associated with the user is charged in real time as the at least one of the communication service and the transaction is provided.

Abstract: Apparatus and method for wireless communication in a wireless communication network includes operating a wireless device on a first wireless communication technology. Aspects also include detecting a cell of a second wireless communication technology and determining the detected cell of the second wireless communication technology satisfies a first reselection criterion based on a first measurement. Still further the aspects includes expediting a determination of whether to perform cell reselection to the second wireless communication technology based on the detected cell of the second wireless communication technology satisfying the first reselection criterion. Additionally, aspects include determining to reselect to the detected cell of the second wireless communication technology when the at least one new measurement satisfies a second reselection criterion for the reselection time period.

Abstract: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.

Abstract: Embodiments provide an integrated antenna system that enables dual-use operation (e.g., communications and navigation). In an embodiment, the integrated antenna system includes a sleeve monopole antenna system and stacked shorted annular ring (SAR) patch antenna system, which are compactly integrated to fit on a military handset or a smart phone. In an embodiment, the integrated antenna system enables communication in the 225-450 MHz Ultra-High Frequency (UHF) band and reception of various Global Navigation Satellite System (GNSS) bands.

Abstract: Methods and apparatus for dynamic search management in a multi-mode device. In one embodiment, a mobile device performs network search and acquisition by dynamically changing search delays and/or search frequencies. In one implementation, the mobile device adjusts the amount of time allocated for each network search based on e.g., previous network connection history (e.g., previously connected to a home network, previously connected to a roaming network), device conditions, user preferences, geographical information, etc. By focusing search effort on cellular technologies which have a high likelihood of success, the mobile device can greatly improve search time and reduce unnecessary power consumption.

Abstract: A system, method, and computer program product are provided for performing a remedial action with respect to a first device utilizing a second device. In use, data is received from a first device at a second device via a network. Additionally, it is determined whether the data is unwanted, utilizing the second device. Furthermore, a remedial action is performed utilizing the second device at least partially blocking the first device from accessing the network, based on the determination.

Abstract: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.

Abstract: A low power interconnect allows client to client communication using an XBAR architecture. An XBAR compiler generates chip designs with XBAR data paths structured to reduce energy consumption and delay. Repeaters inserted into XBAR data paths reduce resistance capacitance (RC) delays so that a design can support desired frequency specifications along a path. Dynamic power consumption is reduced by inserting latch repeaters in the XBAR track. The latch repeaters each include a transmission gate and a latch. Select circuitry couples selected clients to a path. Enable circuitry opens the transmission gates located on the path between the selected clients. Latch repeaters that are not enabled on a given communication cycle gate off the unused portions of the path and maintain the data that was latched on a previous cycle.

Abstract: A system and a method for protecting the occupant of a vehicle during a side-impact detects an approaching vehicle and identifies a collision threat. A collision threat level is assessed based on a set of parameters, and when the collision threat exceeds a pre-determined collision threat threshold level, the system unlatches the occupant's door, pushes it a few centimeters outwards, and locks it in that position. Pressure sensors and accelerometers disposed at suitable locations on the sides of the vehicle, provide crash signals to a Restraint Control Module (RCM). When the crash signals exceed a certain threshold, the RCM commands an airbag deployment module to deploy the airbag between the occupant and the door. Since the door is pushed outwards, an extra pre-crush space is created between the occupant and the door, which allows the use of larger and softer side airbags to provide enhanced protection to the vehicle occupants.

Abstract: An exemplary method correlates a steering device position to a steered element position by determining a target steering angle based on a detected position of the steering device; determining a vehicle steering angle based on a detected position of the steered element; determining a steering correction based on comparing the target steering angle to the vehicle steering angle; and applying a steering control multiplier to affect the steering correction in response to a difference between the target steering angle and the vehicle steering angle being larger than a threshold difference, and in response to a detected vehicle parameter.