Abstract: The invention concerns bicyclic compounds of Formula I wherein R1, R2, L1, L2, J, Y, k, n, p and r are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

Abstract: A system, circuit and method for improving system-on-chip (SoC) bandwidth performance for high latency peripheral read accesses using a bridge circuit are disclosed. In one embodiment, the SoC includes the bridge circuit, one or more bus masters, at least one high bandwidth bus slave and at least one low bandwidth bus slave that are communicatively coupled via a high bandwidth bus and a low bandwidth bus. Further, the bus masters access the at least one low bandwidth bus slave by issuing an early read transaction request in advance to a scheduled read transaction request. Furthermore, the bridge circuit receives the early read transaction request and fetches data associated with the early read transaction request. In addition, the bridge circuit receives the scheduled read transaction request. The fetched data is then sent to the bus masters upon receiving the scheduled read transaction request.

Abstract: The embodiments described herein generally relate to methods and systems for tunneling arbitrary binary data between an HTTP endpoint and an arbitrary destination. Such tunneling of data is valuable in an environment, for example, in which a browser-based client communicates in the HTTP protocol and desires to exchange data with a remote endpoint understanding non-HTTP communications. A relay server is used as a “middle man” to connect the client to the destination, and components supporting the necessary protocols for data exchange are plugged into the relay server. To achieve reliable and ordered transmission of data, the relay server groups sessions through the assignment of session identifiers and tracks the exchange of messages through the assignment of sequence and acknowledgment numbers. Further, the relay server provides for authenticating the HTTP endpoint with the destination and for handling other operations not available in the constrained environment of the Web-based client.

Abstract: A method, article of manufacture, and apparatus for restoring data. In some embodiments, this includes determining an object to be recovered, determining a representation of the object, and requesting the representation of the object from a data resource system. In some embodiments, the representation of the object is a hash value of the object. In some embodiments, the representation of the object is a segment of the object.

Abstract: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.

Abstract: The present invention relates to an improved process for the preparation of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide—Sunitinib base of formula (I) and its pharmaceutically acceptable malate salt of formula (I(a)).

Abstract: Signal processing devices normally filter the signal to reduce noise. Any filtering is likely to eliminate useful components of the signal too. A device for and method of signal processing is disclosed, wherein intrinsically clean signal cycles are selected for reproduction so that the processed signal retains components of all frequencies. A system that uses the disclosed device and the method for processing periodic physiological signals is also disclosed.

Abstract: In one implementation, a physical version of a document is converted to a digital representation of the physical version and a new certificate is computed for the digital representation of the physical version. The new certificate is computed based on the digital representation of the physical version, at least one processing step performed on the digital representation, and a prior certificate computed for a prior digital representation indicative of the physical version. In another implementation, a document is validated.

Abstract: Devices, methods and instructions encoded on computer readable medium for implementation of a dual-adjacency between edge devices of a network site. A first edge device comprises one or more local interfaces configured for communication, via a local network, with one or more network devices co-located in a first network site. The first edge device also comprises one or more overlay interfaces configured for communication, via a core network, with one or more network devices located in one or more other network sites connected to the core network. The first edge device comprises a processor configured to establish, via at least one of the local interfaces, a site communication channel with a second edge device co-located in the first network site. The processor is further configured to establish an overlay communication channel, via at least one of the overlay interfaces, with the second edge device.

Abstract: The various embodiments of the present invention provide a system and method for delivering a haptic force feedback during a vocational tool operation. According to an embodiment, the system comprises a moving capstan drive mechanism connected to a holder and a motor. A sensor detects the rotation speed of a motor. A control circuit is connected to the sensor and to an information processor loaded with virtual reality environment software to provide a feedback force to the user, when the holder is displaced. The linear displacement of the holder is converted into a rotational movement of motor. The sensor outputs a signal based on the rotational speed of the motor to the control circuit to provide a haptic feedback force to a user and to provide a display, when the holder is displaced linearly by the user.

Abstract: An improved database system may include a root-server including a computer processor. The system may also include a segment-server including a computer processor, the segment-server to store data based upon the data's frequency of use by a client who is closer to the segment-server than the root-server and any other segment-server in the system, and the data stored is at least write data. The system may further include a consistency unit to update the root-server based upon data stored by the segment-server and client.

Abstract: An improved computer system may include a server carrying a computer processor in a Fibre Channel over Convergence Enhanced Ethernet (FCoCEE) network. The system may also include a reservation system in communication with the server that utilizes enhanced transmission selection (ETS) to reserve bandwidth for a priority group by scheduling bandwidth for the priority group based upon a projected workload.

Abstract: An aspect of the present invention provides for capturing of audit trail data related to processing of requests. In an embodiment, the received requests are classified into a first category and a second category. For each request in the first category, the corresponding audit trail data is stored directly into non-volatile storage upon processing of the request. On the other hand, for each request in the second category, the audit trail data is first stored into a volatile memory upon processing of the request, and then later copied from the volatile memory to non-volatile storage. Thus, the audit trail data corresponding to both categories of requests is eventually available stored on non-volatile storage.

Abstract: A circuit includes a plurality of capacitors responsive to a plurality of latches that store a test code. A first bit line is coupled to a bit cell and coupled to a sense amplifier. A second bit line is coupled to the bit cell and coupled to the sense amplifier. A differential charge from a set of the plurality of capacitors is applied to the first bit line and to the second bit line. The set of the plurality of capacitors is determined based on the test code and the test code is independent of an output of the sense amplifier.

Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.

Abstract: End-to-end testing of applications across networks is enabled. To test the application and the infrastructure subsystems, an application server connected to the network contains an application under test. A response simulator is connected to the other end of the network. A test module is accessible to the application and to the simulator and contains a test message to be transmitted to the simulator, and an expected response message from the simulator. The application transmits each test message and compares a response message from the simulator to an expected response message. The simulator obtains the response to each test message from the test module.

Abstract: Techniques for providing a direct injection semiconductor memory device are disclosed. In one particular exemplary embodiment, the techniques may be realized as a direct injection semiconductor memory device including a first region connected to a bit line extending in a first orientation and a second region connected to a source line extending in a second orientation. The direct injection semiconductor memory device may also include a body region spaced apart from and capacitively coupled to a word line extending in the second orientation, wherein the body region is electrically floating and disposed between the first region and the second region. The direct injection semiconductor memory device may further include a third region connected to a carrier injection line extending in the second orientation, wherein the first region, the second region, the body region, and the third region are disposed in sequential contiguous relationship.

Abstract: The present invention relates to compositions comprising at least one fluoroolefin and an effective amount of stabilizer that may be at least one phenol or a mixture of at least one phenol with other stabilizers. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers, and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

Abstract: Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C1-C10 unsubstituted alkyl group or fluoroalkyl group.

Abstract: The present application provides a water wash system for use with a compressor of a gas turbine engine. The water wash system may include a number of spray nozzles in communication with the compressor, a heat recovery steam generator, a flow of heating water from the heat recovery steam generator, and a tap off line in communication with the flow of heating water and the spray nozzles so as to deliver the flow of heating water to the compressor.