Abstract: A system may receive a request to migrate a first distributed ledger, maintained by a first distributed ledger management system, to a second distributed ledger management system, and may generate first verification information based on information recorded to the first distributed ledger. The system may instruct the second distributed ledger management system to establish a second distributed ledger, such that the second distributed ledger management system maintains the second distributed ledger. The system may also instruct the second distributed ledger management system to record the information, recorded to the first distributed ledger, to the second distributed ledger. The system may generate second verification information based on the information recorded to the second distributed ledger, and verify that the first distributed ledger has been migrated to the second distributed ledger management system by comparing the first verification information to the second verification information.

Abstract: The present invention provides for indirect access to public cloud-based computing environments for the purpose of running ad-hoc commands, on-demand, on any public cloud-based computing resource. Messages including the ad-hoc commands are communicated to a cloud-based command queue, which acts as the intermediary between the user (i.e., command requester) and the public cloud-based computing resources. A command executor agent installed on the cloud-based computing resources, polls the command queue for commands designated for the application(s) currently being executed on the cloud-based computing resources. Results of the command are communicated from the cloud-based computing resource to the command queue, which is periodically polled by a monitoring queue in order for the user/command requester to obtain the results of the execution of the command.

Abstract: Described herein are a system and techniques for dynamically generating targeted media content. In some embodiments, the system identifies an appropriate template based on the content currently being consumed by a user, preferences or attributes associated with that user, a product to be presented, or any other suitable factor. Once a temple has been selected, a product may be selected for presentation to the user based on the content currently being consumed by a user, preferences or attributes associated with that user, or any other suitable factor. The selected template is then populated using attributes of the user and/or the product. Once populated, the text in the populated template may be smoothed. The generated content may then be synthesized into a different format, in order to match a format of content currently being consumed by a user, which may then be presented to the user.

Abstract: The present invention provides for indirect access to public cloud-based computing environments for the purpose of running ad-hoc commands, on-demand, on any public cloud-based computing resource. Messages including the ad-hoc commands are communicated to a cloud-based command queue, which acts as the intermediary between the user (i.e., command requester) and the public cloud-based computing resources. A command executor agent installed on the cloud-based computing resources, polls the command queue for commands designated for the application(s) currently being executed on the cloud-based computing resources. Results of the command are communicated from the cloud-based computing resource to the command queue, which is periodically polled by a monitoring queue in order for the user/command requester to obtain the results of the execution of the command.

Abstract: Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic psychostimulant are disclosed. In some embodiments, addiction is treated by agonizing bile acid receptors in the subject. For example, in some embodiments, the method comprises administering to the subject a therapeutically effective amount of a composition comprising a therapeutically effective amount of a bile acid receptor agonist. In some embodiments, the method comprises surgically diverting bile acids in the subject in a manner suitable to increase circulating bile acids in the subject.

Abstract: Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic psychostimulant are disclosed. In some embodiments, addiction is treated by agonizing bile acid receptors in the subject. For example, in some embodiments, the method comprises administering to the subject a therapeutically effective amount of a composition comprising a therapeutically effective amount of a bile acid receptor agonist. In some embodiments, the method comprises surgically diverting bile acids in the subject in a manner suitable to increase circulating bile acids in the subject.

Abstract: Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic psychostimulant are disclosed. In some embodiments, addiction is treated by agonizing bile acid receptors in the subject. For example, in some embodiments, the method comprises administering to the subject a therapeutically effective amount of a composition comprising a therapeutically effective amount of a bile acid receptor agonist. In some embodiments, the method comprises surgically diverting bile acids in the subject in a manner suitable to increase circulating bile acids in the subject.

Abstract: A computer implemented method, apparatus, and computer-usable program product for exchanging data using data transformation are provided. A first data binding component receives data from a function selector. A set of data bindings capable of invocation by the first data binding component is available. The function selector determines a content type associated with the data. The first data binding component receives the data and the content type from the function selector. The first data binding component invokes a data binding corresponding to the content type from the set of data bindings to transform the data into a data object. The data object has an object name. A target application is determined based on the object name, and the data object is then routed to a target application.

Abstract: A system for signal processing comprising a cyclic analog to digital converter structure having a first stage and a second stage, wherein the first stage is configured to receive an input signal to perform 1.5 bits/stage ADC and to generate a first stage output signal, and the second stage is configured to receive the first stage output signal and to perform fine offset tuning using a final conversion phase. The second stage further configured to perform 1.5 bits/stage ADC and to generate a second stage output that is fed back to the first stage to iteratively generate a next 1.5 bits, until (N?3) most significant bits of N bits of data are generated. A third stage configured to generate a three least significant bits of the N bits of data using a flash ADC sampling circuit that samples a residue signal at the output of the first stage.

Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.

Abstract: The present invention provides Fused Tricyclic Compounds of the Formula (I) wherein Q, R1, R2, R3, and R4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders.

Abstract: A method includes determining a source URI and extracting meta data from a resource downloaded from a network; storing the source URI and extracted meta data; and utilizing the stored URI and extracted meta data to formulate a search for another resource located on the network. A computer and computer program code are also provided.

Abstract: A system for signal processing comprising a cyclic analog to digital converter structure having a first stage and a second stage, wherein the first stage is configured to receive an input signal to perform 1.5 bits/stage ADC and to generate a first stage output signal, and the second stage is configured to receive the first stage output signal and to perform fine offset tuning using a final conversion phase. The second stage further configured to perform 1.5 bits/stage ADC and to generate a second stage output that is fed back to the first stage to iteratively generate a next 1.5 bits, until (N?3) most significant bits of N bits of data are generated. A third stage configured to generate a three least significant bits of the N bits of data using a flash ADC sampling circuit that samples a residue signal at the output of the first stage.

Abstract: The present invention provides Fused Tricyclic Compounds of the Formula (I) wherein Q, R1, R2, R3, and R4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders.

Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.

Abstract: The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as pulmonary arterial hypertension, migraine, hypertension, disorders of the gastrointestinal tract, restenosis, asthma, obstructive airway disease, prostatic hyperplasia and priapism, anxiety, depression, schizophrenia, neural injury and stroke. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also provided.

Abstract: The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract: Where code execution results in an error attributable to multiple data elements, the code is revised so the error results from one element. Where execution improperly functions without error, and the elements contain required but missing properties, the code is improperly functioning in its required-property handling. Errors are organized into classes and error-causing elements are organized into independent sets corresponding to the classes. Elements that are not within any set are determined. Symptom, error, no-error, refined-symptom, and function databases can be employed during code execution analysis. Symptom database entries correspond to elements and indicate errors, or that no errors, are attributable to the elements. Error database entries correspond to elements resulting in errors upon execution. No-error database entries correspond to elements resulting in no errors upon execution. Refined-symptom database entries correspond to root cause elements of errors.

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-? or combinations thereof.

Abstract: A method includes determining a source URI and extracting meta data from a resource downloaded from a network; storing the source URI and extracted meta data; and utilizing the stored URI and extracted meta data to formulate a search for another resource located on the network. A computer and computer program code are also provided.