Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.

Abstract: Heated chuck plates and apparatus using the same where a heated chuck or tooling plate has a body including an external surface, the body configured to secure an electronics assembly near the external surface, and an air channel network configured to selectively direct heated air to a plurality of predetermined locations on the electronics assembly, the air channel network including: a first heating pathway configured to direct the heated air through the external surface and onto a first location of the plurality of predetermined locations, and a second heating pathway configured to direct the heated air through the external surface and onto a second location of the plurality of predetermined locations.

Abstract: A multiport passive photonic light circuit chip has multiple waveguides written in at least two layers on a glass substrate. Some waveguides connect transmitting and receiving ports of an optical channel, some waveguides redirect a fraction of optical signals to some other receiving ports, and waveguides have circular cross-sectional shapes wherein a refractive index contrast is in the range of 0.2% to 2%.

Abstract: A device and method are provided for interrupting power to a branch circuit and connected load. The device includes a first ground fault (GF) sensor for monitoring a first leakage current across line conductor(s) and grounding conductor of the branch, which ignores leakage current across the grounding conductor, and a second GF sensor for monitoring a second leakage current of the load from the line conductor(s), which takes into account leakage current across the grounding conductor. A processor(s) detects for a GF on the branch circuit based on the first leakage current monitored by the first GF sensor; detects for a GF at the load due to excessive leakage current based on the second leakage current and an allowable/acceptable amount of leakage current for the load; and controls an interruption of power to the branch circuit if the GF on the branch circuit or at the load is detected.

Abstract: Systems and methods for providing ground fault detection in HVAC and other types of equipment allow an appropriate or safe level of grounding conductor leakage current from the equipment while at the same time providing let-go current protection for branch circuit conductors feeding the equipment. In some embodiments, the systems and methods herein are implemented in the form of a ground fault interrupting system that is specifically designed to operate outdoors, and may be installed at the equipment outlet disconnect device typically mounted on an exterior wall near the equipment. In some embodiments, the ground fault interrupting system incorporates the outlet disconnect device therein. In either case, the ability of the ground fault interrupting system to be located outdoors near the equipment allows technicians to more easily install, access, and service the ground fault interrupting system compared to an indoor arrangement.

Abstract: The present disclosure provides engineered capsid proteins and recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein. In particular, the disclosure provides AAV9 virions with engineered AAV9 capsid, AAV5/9 chimeric capsid, or combinatory capsid that achieves increased transduction efficiency in heart, increased heart-to-liver ratio, and/or other desirable properties.

Abstract: A Logically Composed System (LCS) resource policy enforcement system includes resource devices coupled to an LCS provisioning administrator device, a client system, and an orchestrator device coupled to the resource devices and the client system. The orchestrator device uses a first subset of the resource devices to provide an LCS to the client system based on a workload intent provided by the client system, associates the LCS with a client identifier for the client system, and tags each of the first subset of the resource devices being used to provide the LCS with the client identifier. The orchestrator device then identifies a LCS policy for the LCS and applies the LCS policy to each of the first subset of the resource devices tagged with the client identifier to cause the LCS policy to be enforced on the client system and the LCS provisioning administrator device.

Abstract: The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein identified using a high-throughput sequencing screen or rational design. In particular, the disclosure provides AAV5 virions and capsid proteins with increased transduction efficiency in cardiac cells, increased cell-type selectivity, and/or other desirable properties.

Abstract: In some aspects, cardiac-specific expression cassettes are provided herein. In some aspects, provided herein is an expression cassette comprising a polynucleotide sequence encoding a gene product for therapy of a heart disease, wherein the polynucleotide sequence is operably linked to promoter (e.g., a cardiac-specific promoter), and optionally an enhancer (e.g., a cardiac-specific enhancer). In some aspects, the disclosure provides recombinant adeno-associated virus (rAAV) virions, comprising a capsid protein and a viral genome comprising an expression cassette comprising a polynucleotide sequence encoding a therapeutic gene product, e.g., dwarf open reading frame (DWORF) polypeptide, operably linked to a promoter, the expression cassette flanked by inverted terminal repeats. The disclosure further provides pharmaceutical compositions and methods of treating or preventing heart disease.

Abstract: The present invention provides modular trays having cutout features that are configured to engage with a mounting feature of one or more removable rails. The removable rails may be removably secured to a tray body in a plurality of positions to allow a user to install or uninstall rails to support different sized fiber optic modules. For example, a tray may support a twenty-four optical fiber module, two twelve optical fiber modules, or three eight optical fiber modules. Fiber optic enclosures housing the trays can be affixed to the outside of a fiber optic enclosure and allow for easy stacking and unstacking.

Abstract: A stain resistant shirt collar protector is described herein. The stain resistant shirt collar protector is formed having a longitudinal fold line configured to engage a collar fold line. The longitudinal fold line terminates in oblique ends configured to align with edges of the shirt collar. Furthermore, different forms of adhesives and materials may be used to form the stain resistant shirt collar protector, as described in detail herein.

Abstract: A multiport passive photonic light circuit chip has multiple waveguides written in at least two layers on a glass substrate. Some waveguides connect transmitting and receiving ports of an optical channel, some waveguides redirect a fraction of optical signals to some other receiving ports, and waveguides have circular cross-sectional shapes wherein a refractive index contrast is in the range of 0.2% to 2%.

Abstract: In some aspects, cardiac-specific expression cassettes are provided herein. In some aspects, provided herein is an expression cassette comprising a polynucleotide sequence encoding a gene product for therapy of a heart disease, wherein the polynucleotide sequence is operably linked to promoter (e.g., a cardiac-specific promoter), and optionally an enhancer (e.g., a cardiac-specific enhancer). In some aspects, the disclosure provides recombinant adeno-associated virus (rAAV) virions, comprising a capsid protein and a viral genome comprising an expression cassette comprising a polynucleotide sequence encoding a therapeutic gene product, e.g., dwarf open reading frame (DWORF) polypeptide, operably linked to a promoter, the expression cassette flanked by inverted terminal repeats. The disclosure further provides pharmaceutical compositions and methods of treating or preventing heart disease.

Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.

Abstract: The present invention provides modular trays having cutout features that are configured to engage with a mounting feature of one or more removable rails. The removable rails may be removably secured to a tray body in a plurality of positions to allow a user to install or uninstall rails to support different sized fiber optic modules. For example, a tray may support a twenty-four optical fiber module, two twelve optical fiber modules, or three eight optical fiber modules. Fiber optic enclosures housing the trays can be affixed to the outside of a fiber optic enclosure and allow for easy stacking and unstacking.

Abstract: The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein identified using a high-throughput sequencing screen or rational design. In particular, the disclosure provides AAV5 virions and capsid proteins with increased transduction efficiency in cardiac cells, increased cell-type selectivity, and/or other desirable properties.

Abstract: A stain resistant shirt collar protector is described herein. The stain resistant shirt collar protector is formed having a longitudinal fold line configured to engage a collar fold line. The longitudinal fold line terminates in oblique ends configured to align with edges of the shirt collar. Furthermore, different forms of adhesives and materials may be used to form the stain resistant shirt collar protector, as described in detail herein.

Abstract: A circuit breaker can include a housing configured to fit within a slot of a circuit panel and a display configured to display information. The display can include a touch zone configured to allow touch inputs, a variable image zone configured to display trip information, status information, and/or label information, and a fixed image zone configured to display fixed text that is at least partially coincident with the touch zone. Certain embodiments can include a remotely operated circuit breaker with thermal, magnetic, ground fault and arc fault protection.

Abstract: A circuit breaker can include a housing configured to fit within a slot of a circuit panel and a display configured to display information. The display can include a touch zone configured to allow touch inputs, and a variable image zone configured to display information and at least partially coincident with the touch zone. The circuit breaker can also include a logic module operatively connected to the touch zone to receive the touch inputs, and operatively connected to the variable image zone to display information thereon based on the one or more touch inputs.

Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.