Abstract: The present disclosure relates to a L-glutamic acid-producing recombinant microorganism comprising a SbtA protein or a polynucleotide encoding the SbtA protein, and to a method for producing L-glutamic acid by using the same.

Abstract: The present invention relates to a nanoliposome-microbubble conjugate, in which a complex of a Cas9 protein, a guide RNA inhibiting SRD5A2 gene expression and a cationic polymer is encapsulated in a nanoliposome, and to a composition for the amelioration or treatment of hair loss containing the same. Currently, drugs used for the treatment of hair loss cause serious side effects such as loss of libido or erectile dysfunction, and hair loss progresses again when drug treatment is stopped. However, when the nanoliposome-microbubble conjugate of the present invention is used, the expression of SRD5A2 inducing hair loss can be fundamentally suppressed, and the treatment of male hair loss can be performed very effectively.

Abstract: The present invention relates to a nanoliposome-microbubble conjugate, in which a complex of a Cas9 protein, a guide RNA inhibiting SRD5A2 gene expression and a cationic polymer is encapsulated in a nanoliposome, and to a composition for the amelioration or treatment of hair loss containing the same. Currently, drugs used for the treatment of hair loss cause serious side effects such as loss of libido or erectile dysfunction, and hair loss progresses again when drug treatment is stopped. However, when the nanoliposome-microbubble conjugate of the present invention is used, the expression of SRD5A2 inducing hair loss can be fundamentally suppressed, and the treatment of male hair loss can be performed very effectively.

Abstract: An aspect provides a method of increasing efficiency of somatic cell nuclear transfer using a substance (RS-1) increasing Rad51 activity, and a somatic cell nuclear transfer cell prepared according to the method. Another aspect provides a method of screening for a substance increasing Rad51 activity to increase efficiency of somatic cell nuclear transfer. When the substance increasing Rad51 activity is used, efficiency of somatic cell nuclear transfer may be increased.

Abstract: Disclosed herein is a colored metal that includes a metal substrate containing a first metal, an oxidation degree control pattern positioned on the metal substrate, and increasing or decreasing a degree of oxidation of the first metal over time, and a coating film positioned on the metal substrate where the oxidation degree control pattern is positioned, wherein a first region of the metal substrate where the oxidation degree control pattern is present thereon and a second region of the metal substrate where the oxidation degree control pattern is not present thereon exhibit different colors due to a difference in degree of oxidation over time.

Abstract: The present invention relates to a use of 3,6-anhydro-L-galactose for preventing dental caries. More specifically, 3,6-anhydro-L-galactose inhibits the growth of oral microorganisms and exhibits anti-caries activity to inhibit the production of acids caused by the consumption of a carbon source by the oral microorganisms. Thus, 3,6-anhydro-L-galactose can be used in pharmaceuticals, food products, oral hygiene preparations, etc. for preventing, ameliorating or treating oral diseases caused by oral microorganisms, such as dental caries, gingivitis, periodontitis, oral mucosal ulcer, halitosis or xerostomia.

Abstract: A composite hollow fiber membrane having improved water permeability and peel strength and a manufacturing method thereof are disclosed. The composite hollow fiber membrane includes a tubular polymer membrane having an outer surface and an inner surface, and a tubular braid disposed between the outer surface and the inner surface of the tubular polymer membrane, the tubular braid comprises a plurality of yarns, each of the yarns includes first multifilaments and second multifilaments, each of the first multifilaments includes a plurality of first monofilaments having fineness of 3 to 50 denier, and each of the second multifilaments includes a plurality of second monofilaments having fineness of 0.4 to 3 denier.

Abstract: The present invention relates to: a porous polymer material having a porous structure over the entire polymer and having a dense porous structure in which pores are connected to each other therein. The porous polymer material is harmless to the human body as it does not use toxic organic solvents. In addition, a porous polymer material can be prepared without using any additives for forming pores and the particle size can be easily controlled, and thus a polymer material suitable for various uses can be prepared. Furthermore, the extended release of a loaded bioactive material is possible only by the dense porous structure of a polymer itself without using an additive and a surface modification method in the porous polymer material of the present invention. Therefore, the porous polymer material can be applied to a biodegradable material in various bio-fields requiring the extended release of a bioactive material.

Abstract: Disclosed are an extendable pressurized-type hollow fiber membrane module which facilitates improvement of filtrate quality through a multistep-filtration, enhanced easiness of installation and maintenance, decrease of footprint, and/or enlargement of filtration apparatus (without causing decrease of permeate flux of a unit hollow fiber membrane), and a filtration apparatus manufactured using the same. The filtration apparatus of the present invention comprises first and second pressurized-type hollow fiber membrane modules, wherein an inlet port of the first pressurized-type hollow fiber membrane module for introducing feed water and an outlet port of the second pressurized-type hollow fiber membrane module for discharging filtrate or air are coupled to each other.

Abstract: An energy-saving filtering system and a hollow fiber membrane module for the same are disclosed. According to the filtering system of the present invention, pretreated feed water flows into the case of the hollow fiber membrane module by gravity, and the filtrate passing through the hollow fiber membrane is discharged from the hollow fiber membrane module by gravity.

Abstract: The present invention relates to a use of 3,6-anhydro-L-galactose for preventing dental caries. More specifically, 3,6-anhydro-L-galactose inhibits the growth of oral microorganisms and exhibits anti-caries activity to inhibit the production of acids caused by the consumption of a carbon source by the oral microorganisms. Thus, 3,6-anhydro-L-galactose can be used in pharmaceuticals, food products, oral hygiene preparations, etc. for preventing, ameliorating or treating oral diseases caused by oral microorganisms, such as dental caries, gingivitis, periodontitis, oral mucosal ulcer, halitosis or xerostomia.

Abstract: Disclosed are system and method for filtration which can minimize the contamination of the filtering membrane through a pretreatment and perform the pretreatment and the filtration with a filtering membrane in a single filtering unit so that any need for separate and additional space and facility for the pretreatment can be obviated. The system for filtration of the present invention comprises a fine bubble supplier for providing fine bubbles into the feed water. The pretreatment is performed by supplying the feed water to be treated into the filtering unit through a dynamic filtration layer which is formed in the filtering unit as the fine bubbles rise.

Abstract: The present disclosure relates to a biomarker for predicting the sensitivity to a protein kinase inhibitor and a use thereof. The present disclosure provides a marker, a composition, and a kit for predicting the sensitivity to a protein kinase inhibitor, and a prediction method thereof. According to the present disclosure, the marker has an excellent effect of predicting the sensitivity to a protein kinase inhibitor, and thus the present disclosure can be useful for cancer treatment.

Abstract: The present invention relates to an anticancer supplement containing loperamide as an active ingredient. More specifically, a proteasome inhibitor alone cannot exhibit an anticancer effect on solid cancers and some blood cancers, but when the proteasome inhibitor and loperamide are co-administered or a composition containing the proteasome inhibitor and loperamide is provided, cancer cell death by the proteasome inhibitor can be effectively induced, thereby exhibiting an improved anticancer effect, and enhancing anticancer effects on solid cancers and blood cancers while reducing side effects caused by a high-concentration of the proteasome inhibitor. Therefore, the composition containing the proteasome inhibitor and loperamide as active ingredients, according to the present invention, can be useful for preventing or treating cancer, and loperamide can be provided as an anticancer supplement when the proteasome inhibitor is used to treat cancer.

Abstract: Disclosed are an extendable pressurized-type hollow fiber membrane module which facilitates improvement of filtrate quality through a multistep-filtration, enhanced easiness of installation and maintenance, decrease of footprint, and/or enlargement of filtration apparatus (without causing decrease of permeate flux of a unit hollow fiber membrane), and a filtration apparatus manufactured using the same. The filtration apparatus of the present invention comprises first and second pressurized-type hollow fiber membrane modules, wherein an inlet port of the first pressurized-type hollow fiber membrane module for introducing feed water and an outlet port of the second pressurized-type hollow fiber membrane module for discharging filtrate or air are coupled to each other.

Abstract: The present invention relates to: a porous polymer material having a porous structure over the entire polymer and having a dense porous structure in which pores are connected to each other therein. The porous polymer material is harmless to the human body as it does not use toxic organic solvents. In addition, a porous polymer material can be prepared without using any additives for forming pores and the particle size can be easily controlled, and thus a polymer material suitable for various uses can be prepared. Furthermore, the extended release of a loaded bioactive material is possible only by the dense porous structure of a polymer itself without using an additive and a surface modification method in the porous polymer material of the present invention. Therefore, the porous polymer material can be applied to a biodegradable material in various bio-fields requiring the extended release of a bioactive material.

Abstract: Disclosed are a pressurized-type hollow fiber membrane module having a pressure resistance higher than 3 kgf/cm2 and a filtration system comprising the same. The pressurized-type hollow fiber membrane module comprises: a body case having an open end; a fixing member disposed in the body case at the open end; a hollow fiber membrane potted in the fixing member; and a cap on the open end of the body case, the cap and fixing member forming a filtrate-collecting space, wherein a lumen of the hollow fiber membrane is in fluid communication with the filtrate-collecting space, the fixing member has a step so that an upper side surface of the fixing member is not in contact with an inner surface of the body case, and a portion of the cap is inserted in a groove defined by the step of the fixing member and the inner surface of the body case.