Patents by Inventor A. Robert MacLeod

A. Robert MacLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of histone deactylase
    Publication number: 20030078216
    Abstract: The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
    Type: Application
    Filed: May 3, 2000
    Publication date: April 24, 2003
    Inventors: A. Robert MacLeod, Zuomei Li, Jeffrey M. Besterman
  • Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences
    Patent number: 6506735
    Abstract: The invention provides optimized antisense oligonucleotides complementary to the DNA methyltransferase gene or its RNA transcript. The invention further provides methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic plant and animal studies and gene therapy approaches, and as potential therapeutic agents.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: January 14, 2003
    Assignee: Methyl Gene, Inc.
    Inventor: A. Robert MacLeod