Abstract: A patient-specific instrument is disclosed for performing an osteotomy. The patient-specific instrument includes a body that includes a proximal side, a distal side, a medial side, a lateral side, and an inferior side having a bone engagement surface shaped to match at least one of a first surface of a first bone, a second surface of a second bone, a third surface of a third bone, and a fourth surface of a fourth bone of adjacent joints. The instrument also includes a superior side having one or more guide features that are positioned to guide resection of at least one of the first bone, the second bone, the third bone, and the fourth bone. The body is configured to seat transverse to the adjacent joints with the bone engagement surface engaging at least one of the first surface, the second surface, the third surface, and the fourth surface.

Abstract: An electronic smoking article or electronic vaping article includes a reservoir containing a liquid material and having an outlet, a capillary having a capillary inlet and a capillary outlet, the capillary inlet of the capillary in communication with the outlet of the reservoir, a heater operable to heat the capillary to a temperature sufficient to at least initially volatilize liquid material contained within the capillary, and a shuttle valve between the outlet of the reservoir and the capillary inlet. The shuttle valve is operable to prevent release of liquid material from the reservoir when the shuttle valve is in a closed position and is operable to release liquid material from the reservoir when the shuttle valve is in an open position.

Abstract: A patient-specific instrument is disclosed for performing an osteotomy. The patient-specific instrument includes a body that includes a proximal side, a distal side, a medial side, a lateral side, and an inferior side having a bone engagement surface shaped to match at least one of a first surface of a first bone, a second surface of a second bone, a third surface of a third bone, and a fourth surface of a fourth bone of adjacent joints. The instrument also includes a superior side having one or more guide features that are positioned to guide resection of at least one of the first bone, the second bone, the third bone, and the fourth bone. The body is configured to seat transverse to the adjacent joints with the bone engagement surface engaging at least one of the first surface, the second surface, the third surface, and the fourth surface.

Abstract: A next generation DNA sequencing method and use for accurate and massively parallel quantification of one or more nucleic acid targets. More particularly, the present disclosure is related to the method and a kit comprising probes for detecting and quantifying genetic targets in complex DNA pools primarily used for genetic target and variant detection in human and animal populations and environmental samples. Furthermore, the present disclosure finds particular application in the field of detection of disease-causing genetic alterations in samples obtained from human body, including without limiting biopsies, saliva and other secretions, exhaled moisture extracts, tissue, blood plasma (liquid biopsies) or the like. The present disclosure includes one or more target-specific nucleic acid probes per genetic target (left probe and right probe) and a bridge oligo.

Abstract: Provided are devices, compositions, and methods for surface disinfection and decontamination; the devices generally adapted to contain a single or multi-component indicator composition, and optionally a disinfectant composition, and to dispense the indicator composition and optional disinfectant composition to a disinfectant solution, a surface, or a disinfectant article upon actuation of the device; also provided is an article of manufacture in the form of a removable cartridge adapted to fit a device described here, which may be pre-filled with a single or multi-component indicator composition as described here, and/or with a disinfectant composition, and one or more optional additives.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, and an elongated shaft extending from the housing. The elongated shaft has a proximal end secured to the housing, a distal end spaced from the proximal end, and a first axis extending between the proximal and distal ends of the elongated shaft. Surgical fasteners are disposed in the elongated shaft. The surgical fasteners are stacked at an angle relative to the first axis of the elongated shaft. A distal end cap having a surgical fastener dispensing window is secured to the distal end of the elongated shaft. The applicator instrument has a firing system disposed in the housing, and an actuator coupled with the firing system for activating the firing system to dispense the surgical fasteners through the surgical fastener dispensing window.

Abstract: A car computer, a vehicle, a system and a method, the method comprising: receiving a request and response from a provider, a consumer or a trader to trade information; match the request and response to obtain an information trading deal; and providing details of the information trading deal to a computing platform adapted to be installed within a vehicle, the at least one computing platform configured to manage a blockchain comprising a block associated with the information trading deal.

Abstract: A constant voltage may be used during battery charging to reduce or avoid the formation of a dendrite, such as a stepped constant voltage. For each charging period, each level of the stepped constant voltage may be calculated to ensure a corresponding current level within each period remains below a safe current limit. A voltage transition between any two periods may occur in response to expiration of a predetermined time, or in response to a determination that the current level has fallen below a lower current limit. A current level during each period may be maintained such that the battery heat is maintained below a reference heat level, which may increase battery cycle life (e.g., battery capacity or maximum recharging cycles). The battery heat may be measured directly or indirectly, or may be estimated based on other measured or controlled values.

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

Abstract: A surgical method aids identification of nerves in a body to help prevent damage to the nerves during surgery to the body proximate the nerves. An electrode introduced to within a body cavity through a catheter is placed proximate a nerve within the body cavity by a laparoscopic or robotic device. An exploratory probe placed in the body cavity is selectively placed along a presumed pathway of the nerve to provide an electrical signal through the nerve to the electrode. An analyzer interfaced with the electrode analyzes the electrical signal received at the electrode to determine the proximity of the exploratory probe to the nerve, allowing mapping of the nerve pathway through the body cavity.

Abstract: An electronic smoking article includes an outer housing extending in a longitudinal direction, a liquid aerosol formulation, a heater operable to at least partially volatilize at least a portion of the liquid aerosol formulation and form an aerosol, a power supply operable to apply voltage across the heater, at least one light emitting diode, a charging button assembly including a conductive post operable to form a first external, electrical contact at an upstream end of the electronic smoking article, and a second external, electrical contact including a portion of an outer surface of the outer housing at the upstream end of the electronic smoking article. The first and second external, electrical contacts charge the power supply.

Abstract: The present disclosure provides food compositions for humans comprising a Methylococcus capsulatus protein isolate or whole cell product, wherein the Methylococcus capsulatus protein isolate or whole cell product is composed of at least 70% crude protein; has a protein digestibility corrected amino acid score (PDCAAS) of at least 0.9; and has a ?13C of about ?70‰ to about ?30‰. Methylococcus capsulatus protein isolates or whole cell products provided herein are useful for the manufacture of meat substitutes as well as other food compositions, such as protein bars, nutritional beverages, protein supplement powders, frozen non-dairy desserts, and baked goods.

Abstract: The present disclosure provides method for generating biomass by culturing methanotrophic bacteria under low copper conditions. Also provided are generated biomass and protein isolate prepared from the biomass.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: Described herein are wearable devices and methods for medicament delivery. Example devices can include a housing having an underside adapted to be proximate to a skin surface, and a reservoir disposed in the housing, the reservoir configured to be filled with a medicament to be delivered to the patient. The devices can include a cannula disposed within the housing and coupled to the reservoir, in which the cannula configured to protrude from a port defined by the housing to be positioned in the skin surface. The devices can further include a capacitive sensor configured to detect whether the medicament has leaked from the delivery device, in which the capacitive sensor includes a conductor disposed in a portion of the underside of the housing.

Abstract: Embodiments disclosed herein may relate to weather sensors and particularly to methods and systems related to collecting weather data and other site-specific data. The system may also be used to collect data on hydrometeors, especially hail. Some, but not all of the things a system described can determine are the kinetic energy, diameter, mass, and velocity.

Abstract: An apparatus, system, and method is disclosed for correcting a condition present in a patient. In some aspects, the apparatus may include a resection guide having: a body, resection features that define trajectories that are at least partially determined based on a bone model of at least a portion of the patient's foot. The bone model can be based on medical imaging of the patient's foot. The apparatus includes a first bone attachment feature and second bone attachment feature configured to secure the resection guide to the bone. Also, the apparatus may include at least one complementary component selected from the group having of: an alignment guide; a rotation guide; a compression guide; a correction guide; a positioning guide; a pin guide; and a fixation guide.

Abstract: Embodiments of the disclosure include methods for implementing a predictive model that predicts pluripotency of cells through a cost efficient and non-destructive means. The predictive model analyzes contrast images captured from the cells and outputs predictions of cellular pluripotency at the cellular level. Thus, implementation of the predictive model guides the selection and isolation of cells that are predicted to be pluripotent. Furthermore, the predictive model facilitates retrospective analyses to correlate pluripotency metrics with differentiation success and further enables tracking of cellular pluripotency over time (e.g., to evaluate differentiation of cells).

Abstract: Aspects of the technology described herein describe a system for detecting and reducing wear in industrial equipment. Aspects of the technology use 3D image data from a field inspection of industrial equipment to identify and quantify wear. The wear can be detected by providing the images from the field inspection to a computer classifier for recognition. Aspects of the technology also use machine learning to recommend a change to the operation of the equipment to minimize wear. Such a change could include load shedding, lube oil feed rate changes, prompts for maintenance, etc. Through incorporation of the wear data into the control system, the equipment can automatically change operation to improve wear performance and increase the durability and lifetime of the equipment.

Abstract: Provided are combinations, compositions and kits containing a immune globulin (IG) composition and a soluble hyaluronidase composition formulated for subcutaneous administration. Such products can be used in methods of treating IG-treatable diseases or conditions. Also provided are methods for subcutaneous administration of immune globulin whereby the dosing regimen is substantially the same as for intravenous administration of the same dosage for treatment of the same IG-treatable disease or condition.