Patents by Inventor A. Scott Robertson

A. Scott Robertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD
    Publication number: 20200383963
    Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, orZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.
    Type: Application
    Filed: January 21, 2020
    Publication date: December 10, 2020
    Inventors: Angela Marie CACACE, Luis Gustavo Alejandro ROJAS SOTO, Lorin A. THOMPSON, III, Owen Brendan WALLACE, Lucienne V. RONCO, Ning SHEN, Alan Scott ROBERTSON, Aaron Nakwon CHANG
  • Enhanced flow-based computer network threat detection
    Patent number: 10855705
    Abstract: In one example embodiment, a threat detection server receives metadata of a network flow in a network; a zone definition that correlates the metadata of the network flow with a first zone of network devices in the network and a second zone of network devices in the network, where the network flow was transmitted from the first zone to the second zone; and a security policy for the network flow, where the security policy is enforced on the basis of the first zone and the second zone. Based on the zone definition, the threat detection server annotates a flow record that includes the metadata with an indication of the first zone and the second zone. Based on the annotated flow record and the security policy, the threat detection server determines whether to generate a notification associated with a detection of a security threat associated with the network flow.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 1, 2020
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Matthew Scott Robertson, Darrin Joseph Miller, Sunil Navinchandra Amin, Paul Wayne Bigbee
  • PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED SYSTEMS AND METHODS
    Publication number: 20200360137
    Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus.
    Type: Application
    Filed: July 31, 2020
    Publication date: November 19, 2020
    Inventors: Richard Francis, Scott Robertson, Marian Lally, Alexander Hill, Katherine Miyashiro, Paraic Frisby, James R. Keogh
  • Enhanced microbend sensor
    Patent number: 10837804
    Abstract: An optical fiber sensor includes a first single mode fiber, a second single mode fiber, and a multimode fiber positioned between, and coupled to, the first single mode fiber and the second single mode fiber. The multimode fiber includes a graded-index core with an outer diameter between about 35 ?m and about 45 ?m. A numerical aperture of the core is between about 0.15 and about 0.25. The multimode fiber includes a cladding with an outer diameter between about 70 ?m and about 90 ?m. A coupling strength of an LP01 mode of the first single mode fiber to each of an LP02 mode and an LP03 mode of the multimode fiber is at least about 0.25.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: November 17, 2020
    Assignee: Corning Incorporated
    Inventor: Scott Robertson Bickham
  • High-density optical fiber ribbon and ribbon cable interconnects employing small diameter optical fibers
    Patent number: 10816743
    Abstract: A high-density optical fiber cable interconnect includes a fiber ribbon or fiber ribbon cable having at least one fiber ribbon and first and second ends. The fiber ribbon is formed from small diameter optical fibers arranged in at least one row, with each fiber having a glass section and a non-glass coating section surrounding the glass section. The diameter of the non-glass coating section can be less than 205 microns. A matrix layer encapsulates the small diameter optical fibers to define the fiber ribbon. A first optical connector terminates the first end of the fiber ribbon or fiber ribbon cable and has a first fiber pitch correspond to a standard optical fiber connector. A second optical connector terminates the second end of the fiber ribbon or fiber ribbon cable and has a second fiber pitch less than that of a standard optical fiber connector.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: October 27, 2020
    Assignee: Corning Incorporated
    Inventors: Scott Robertson Bickham, Ulrich Wilhelm Heinz Neukirch
  • USE OF P38 INHIBITORS TO REDUCE EXPRESSION OF DUX4
    Publication number: 20200332291
    Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).
    Type: Application
    Filed: October 5, 2018
    Publication date: October 22, 2020
    Inventors: Angela Marie CACACE, Luis Gustavo Alejandro ROJAS SOTO, Lorin A. THOMPSON, III, Owen Brendan WALLACE, Lucienne V. RONCO, Ning SHEN, Alan Scott ROBERTSON, Aaron Nakwon CHANG
  • Prosthetic heart valve devices and associated systems and methods
    Patent number: 10786352
    Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member. The device further includes an extension member coupled to the anchoring member and having an annular first portion coupled to the anchoring member and a second portion coupled to the first portion. The extension member is folded in a delivery configuration such that the first portion overlaps the second portion. When released from the a delivery catheter, the extension member unfolds such that the first portion extends radially outwardly from the anchoring member and the second portion extends radially outwardly from the first portion.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: September 29, 2020
    Assignee: TWELVE, INC.
    Inventors: Richard Francis, Scott Robertson, Marian Lally, Katherine Miyashiro, Paraic Frisby
  • CASHIER INTERFACE FOR LINKING CUSTOMERS TO VIRTUAL DATA
    Publication number: 20200279240
    Abstract: A system and method for applications of computer vision in linking users with virtual data that can include detecting digital interaction state of a plurality of subjects in an environment using at least one sensor-based monitoring system; detecting a contextual organization of subjects relative to an operator station; at the operator station, augmenting the user interface based on the contextual organization of subjects which comprises of at least: presenting a set of subject indicators in the user interface with the subject indicators arranged in response to contextual organization, and in response to received user interaction with at least one selected subject indicator, accessing the digital interaction state of the subject associated the at least one subject indicator.
    Type: Application
    Filed: March 2, 2020
    Publication date: September 3, 2020
    Inventors: William Glaser, Scott Robertson, Daniel Bennett Lythcott-Haims, Brian Van Osdol
  • PUNCTURE-RESISTANT REDUCED-DIAMETER MULTIMODE OPTICAL FIBER
    Publication number: 20200271858
    Abstract: The present description provides reduced-diameter multimode optical fibers. The optical fibers include a reduced-diameter glass fiber and/or reduced-thickness coatings. The overall diameter of the optical fibers is less than 210 ?m and examples with diameters less than 160 ?m are presented. Puncture resistant secondary coatings enable thinning of the secondary coating without compromising protection of the glass fiber. The optical fibers are suitable for data center applications and features high modal bandwidth, low attenuation, low microbending sensitivity, and puncture resistance in a compact form factor.
    Type: Application
    Filed: February 18, 2020
    Publication date: August 27, 2020
    Inventors: Scott Robertson Bickham, Yangbin Chen, Ching-Kee Chien, Ming-Jun Li, Pushkar Tandon, Ruchi Tandon
  • MULTIMODE OPTICAL FIBER WITH REDUCED CLADDING THICKNESS
    Publication number: 20200271857
    Abstract: The present description provides multimode optical fibers with reduced cladding thickness. The optical fibers include a reduced-diameter glass fiber and/or reduced-thickness coatings. The overall diameter of the optical fibers is less than 210 ?m and examples with diameters less than 160 ?m are presented. Puncture resistant secondary coatings enable thinning of the secondary coating without compromising protection of the glass fiber. The optical fibers are suitable for data center applications and features high modal bandwidth, low attenuation, low microbending sensitivity, and puncture resistance in a compact form factor.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 27, 2020
    Inventors: Scott Robertson Bickham, Pushkar Tandon, Ruchi Tandon
  • CRYPTOGRAPHIC SECURITY AUDIT USING NETWORK SERVICE ZONE LOCKING
    Publication number: 20200252435
    Abstract: In one embodiment, a service receives captured traffic flow data regarding a traffic flow sent via a network between a first device assigned to a first network zone and a second device assigned to a second network zone. The service identifies, from the captured traffic flow data, one or more cryptographic parameters of the traffic flow. The service determines whether the one or more cryptographic parameters of the traffic flow satisfy an inter-zone policy associated with the first and second network zones. The service causes performance of a mitigation action in the network when the one or more cryptographic parameters of the traffic flow do not satisfy the inter-zone policy associated with the first and second network zones.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 6, 2020
    Inventors: Matthew Scott Robertson, David McGrew, Timothy David Keanini, Sunil Amin, Ellie Marie Daw
  • Prosthetic heart valve devices and associated systems and methods
    Patent number: 10729541
    Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: August 4, 2020
    Assignee: Twelve, Inc.
    Inventors: Richard Francis, Scott Robertson, Marian Lally, Alexander Hill, Katherine Miyashiro, Paraic Frisby, James R. Keogh
  • OPTICAL FIBER CABLE WITH HIGH FIBER COUNT
    Publication number: 20200225404
    Abstract: The present disclosure provides optical fibers with an impact-resistant coating system. The fibers feature low attenuation. The coating system includes a primary coating and a secondary coating. The primary coating and secondary coating have reduced thickness to provide low-diameter fibers without sacrificing protection. The primary coating has high tear strength and is resistant to damage caused by mechanical force. The secondary coating has high puncture resistance. The outer diameter of the optical fiber is less than or equal to 190 ?m.
    Type: Application
    Filed: December 17, 2019
    Publication date: July 16, 2020
    Inventors: Scott Robertson Bickham, Ming-Jun Li, Pushkar Tandon, Ruchi Tandon
  • METHOD OF SELECTING WIDEBAND MULTIMODE FIBER FROM 850 NM DIFFERENTIAL MODE DELAYS
    Publication number: 20200174182
    Abstract: A method is described for selecting fibers meeting requirements of a second minimum bandwidth at a second wavelength based on differential mode delay data measured at a first wavelength different from the second wavelength.
    Type: Application
    Filed: November 13, 2019
    Publication date: June 4, 2020
    Inventors: John Steele Abbott, III, Scott Robertson Bickham
  • Cryptographic security audit using network service zone locking
    Patent number: 10673901
    Abstract: In one embodiment, a service receives captured traffic flow data regarding a traffic flow sent via a network between a first device assigned to a first network zone and a second device assigned to a second network zone. The service identifies, from the captured traffic flow data, one or more cryptographic parameters of the traffic flow. The service determines whether the one or more cryptographic parameters of the traffic flow satisfy an inter-zone policy associated with the first and second network zones. The service causes performance of a mitigation action in the network when the one or more cryptographic parameters of the traffic flow do not satisfy the inter-zone policy associated with the first and second network zones.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: June 2, 2020
    Assignee: Cisco Technology, Inc.
    Inventors: Matthew Scott Robertson, David McGrew, Timothy David Keanini, Sunil Amin, Ellie Marie Daw
  • LOW BEND LOSS OPTICAL FIBER WITH STEP INDEX CORE
    Publication number: 20200158945
    Abstract: A single mode optical fiber, comprising: (i) a silica based core having a step refractive index profile with an alpha of greater than 10, a relative refractive index ?1MAX, and an outer radius r1, wherein 6.25 microns>r1?4.75 microns, the core further comprising Cl, Ge, or a combination thereof; (ii) a first cladding region in contact with and surrounding the core, the first cladding region having a relative refractive index ?2MIN, an inner radius r1, and an outer radius r2, wherein r2<20 microns; and (iii) an outer cladding region surrounding the first cladding region, the outer cladding region having a relative refractive index ?3. The fiber <1300 nm, a 22 m cable cutoff wavelength <1260 nm; and a bend loss <0.005 dB/turn when the optical fiber is bent around a 30 mm mandrel; <0.5 dB/turn when the fiber is bent around a 20 mm mandrel.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 21, 2020
    Inventors: Scott Robertson Bickham, Dana Craig Bookbinder, Ming-Jun Li, Snigdharaj Kumar Mishra, Pushkar Tandon
  • HEART VALVE PROSTHESES AND METHODS FOR PERCUTANEOUS HEART VALVE REPLACEMENT
    Publication number: 20200121453
    Abstract: Prosthetic heart valve devices and associated methods for percutaneous heart valve replacement are disclosed herein. A transcatheter valve prosthesis configured in accordance herewith includes a frame having a valve support and one or more support arms coupled thereto. The one or more support arms are configured to extend from the second end of the valve support toward the first end when the valve prosthesis is in an expanded configuration. When deployed in the expanded configuration, the one or more support arms have a curvilinear shape, such as a substantially S-shape, that at least partially engages tissue at the native heart valve.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 23, 2020
    Inventors: Scott ROBERTSON, Elliot HOWARD
  • Low bend loss optical fiber with graded index core
    Patent number: 10564349
    Abstract: A single mode optical fiber, comprising: (i) a silica based core having a graded refractive index profile with an alpha of less than 5, a relative refractive index ?1max, and an outer radius r1, wherein 10 microns>r1?6.5 microns, the core comprising Cl, Ge, or a combination thereof; (ii) a first cladding region in contact with and surrounding the core, the first cladding region having a relative refractive index ?2min, an inner radius r1, and an outer radius r2, wherein r2<20 microns; and (iii) an outer cladding region surrounding the first cladding region, the outer cladding region having a relative refractive index ?3. The fiber has MFD at 1310 nm>than 9 microns, a zero dispersion wavelength <1306 nm; a 22 m cable cutoff wavelength <1260nm; and a bend loss <0.005 dB/turn when the fiber is bent around a 30 mm mandrel; and <0.5dB/turn when the fiber is bent around a 20 mm mandrel.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: February 18, 2020
    Assignee: CORNING INCORPORATED
    Inventors: Scott Robertson Bickham, Dana Craig Bookbinder, Ming-Jun Li, Snigdharaj Kumar Mishra, Pushkar Tandon
  • P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
    Patent number: 10537560
    Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: January 21, 2020
    Assignee: Fulcrum Therapeutics. Inc.
    Inventors: Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
  • ENHANCED MICROBEND SENSOR
    Publication number: 20200003589
    Abstract: An optical fiber sensor includes a first single mode fiber, a second single mode fiber, and a multimode fiber positioned between, and coupled to, the first single mode fiber and the second single mode fiber. The multimode fiber includes a graded-index core with an outer diameter between about 35 ?m and about 45 ?m. A numerical aperture of the core is between about 0.15 and about 0.25. The multimode fiber includes a cladding with an outer diameter between about 70 ?m and about 90 ?m. A coupling strength of an LP01 mode of the first single mode fiber to each of an LP02 mode and an LP03 mode of the multimode fiber is at least about 0.25.
    Type: Application
    Filed: June 5, 2019
    Publication date: January 2, 2020
    Inventor: Scott Robertson Bickham