Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Systems and methods for providing a user interface that facilitates application development. The applications may utilize one or more underlying machine-learning models to perform application functions. Exemplary implementations may: effectuate presentation of an application development interface to developers through client computing platforms associated with the developers; receive, from client computing devices, input information indicating feature values entered and/or selected by the developers via the user interface fields; responsive to receipt of first input information, configure a first application in accordance with the feature values included in a first feature values set; provide the configured application for user by one or more users; and/or other exemplary implementations.

Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: A processor-implemented method and a system for user-selected selected joining two or more research studies to extract analytical insights for enabling cross-study analysis is disclosed. The method includes identifying, using an identification module, at least one matched variable in a statistically representative sample in each of the two or more research studies. The method further includes establishing, using a segment establishing module, for each combination of matched variables, a schema of segments, from the two or more research studies. The method furthermore includes determining, using the segment establishing module if each of the established schema of segments is statistically representative. The method furthermore includes creating a joint study, using a joint study creation module, by combining responses from each of the two or more research studies within each segment of the statistically representative schema of segments.

Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: an array of electrodes, the array configured to be positioned over the subject's body with a front face of the array facing the subject's body, the array comprising electrode elements positioned in existing electrode positions arranged around a centroid of the array; an anisotropic material layer electrically coupled to the array of electrodes and located on a front side of the front face of the array; and at least one void space in the array of electrodes capable of enclosing an areal footprint equivalent to at least a portion of an areal footprint of at least one existing electrode position, and superimposable on at least a portion of at least one existing electrode position by rotation of the array around the centroid.

Abstract: Alternating electric fields (e.g., Tumor Treating Fields or TTFields) can be applied to a subject's body using an apparatus (e.g., a transducer array) that includes a first PCB that has metal pads for coupling an AC signal into the subject's body at high currents, and a second, less expensive PCB that can only handle lower currents. The first PCB is located at a central portion of the apparatus, and the second PCB is located at a peripheral portion of the apparatus. Temperature sensors (e.g., thermistors) are electrically connected to the second PCB. In some embodiments, the second PCB is significantly larger than the first PCB.

Abstract: Alternating electric fields (e.g., tumor treating fields or TTFields) can be applied to a subject's body using electrode assemblies that are made from two discrete subassemblies, which are removably and adhesively connectable to each other. As long as the two subassemblies remain in intimate contact (which can be determined, e.g., by measuring an electrical resistance or an optical reflectance), the system applies an AC voltage to the electrode assemblies. But if (a) the subassemblies within any given electrode assembly become separated (or even begin to separate), or (b) the subassemblies within any given electrode assembly are not aligned correctly, then the system will turn off the AC voltage to that electrode assembly.

Abstract: A light engine with distinct light sources sharing at least one optic may employ scattering particles to change the illuminance line profiles of one or more of the light sources so that they are more uniformly mixed in the far-field. The scattering particles may be integrated into phosphor layers of specific light sources or may be disposed in a separate layer. The scattering particles may be tunable based on the particular characteristics of the light source, such as their spectral characteristics or their chemical mixing characteristics.

Abstract: Systems, devices, and methods for decoding information bits obtained from storage, including obtaining a frame corresponding to a codeword from the storage device, performing a first decoding operation on the frame, based on the first decoding operation indicating that a number of errors is greater than a predetermined number, selecting at least one potential error bit, and perform a second decoding operation based on the at least one potential error bit, based on the second decoding operation indicating that the number of errors is not equal to the predetermined number plus one, determining that the frame is not correctable by the first decoding operation and the second decoding operation, and based on the second decoding operation indicating that the number of errors is equal to the predetermined number plus one, correcting the frame based on a result of the second decoding operation to obtain a corrected frame, and obtaining information bits corresponding to the codeword based on the corrected frame.

Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

Abstract: The subject technology provides for large-scale training of foundation models for physiological signals from wearable electronic devices. An apparatus receives receive input data having a plurality of physiological signal information segments associated with a user. The apparatus applies one or more augmentation functions to the plurality of physiological signal information segments to generate an augmented version of the plurality of physiological signal information segments. The apparatus trains a neural network to produce a trained machine learning model by generating, via an encoder, an embedding of the augmented version having a first number of dimensions in an embedding space. The apparatus maps, via a multilayer perceptron projection, the embedding into a representation having a second number of dimensions. The apparatus determines mutual information between a pair of representations of the augmented version.

Abstract: A system and related methods are disclosed for managing, evaluating and improving identity governance and administration. The system is configured to execute a method, which includes receiving, by a computing system, data associated with the identity governance and administration, classifying, by a computing system, the data associated with the identity governance and administration according to one or more rules, generating, by a computing system, a three-dimensional model using the classified data associated with the identity governance and administration, performing, by a computing system, a statistical analysis, and optionally displaying, by a computing system, the three-dimensional model or results of the statistical analysis, or both.

Abstract: The technology relates generally to an interactive avatar training system. The interactive avatar training system utilizes an interactive platform that allows at least two users, such as a trainer and a trainee, to be in interactive communication in a training program. The interactive avatar training system may assist generating a processed answer or response from the trainer to the trainee so that the answer presented to the trainee has high level of accuracy. Thus, the training efficiency and accuracy may be enhanced and improved.

Abstract: An offshore power generation structure comprising a submerged portion having a first deck portion comprising an integral multi-stage evaporator system, a second deck portion comprising an integral multi-stage condensing system, a third deck portion housing power generation equipment, cold water pipe; and a cold water pipe connection.

Abstract: Systems and methods are provided for obtaining data annotations from a crowdsourced group of individuals. The individuals can be provided with a set of data describing damage to an item and a variety of annotations can be applied to the data. In a variety of embodiments, multiple individuals can review the same claim and a final claim outcome can be determined based on the multiple reviews. In many embodiments, machine classifiers can process the set of data to identify particular features within the data. Scoring data can be generated, based on annotations provided by other individuals and/or machine classifiers that reflects the adjuster's skill at identifying features within the data and annotating the data. Claims can be assigned to individuals based on the score assigned to the individual.

Abstract: Bias circuits and methods for silicon-based amplifier architectures that are tolerant of supply and bias voltage variations, bias current variations, and transistor stack height, and compensate for poor output resistance characteristics. Embodiments include power amplifiers and low-noise amplifiers that utilize a cascode reference circuit to bias the final stages of a cascode amplifier under the control of a closed loop bias control circuit. The closed loop bias control circuit ensures that the current in the cascode reference circuit is approximately equal to a selected multiple of a known current value by adjusting the gate bias voltage to the final stage of the cascode amplifier. The final current through the cascode amplifier is a multiple of the current in the cascode reference circuit, based on a device scaling factor representing the relative sizes of the transistor devices in the cascode amplifier and in the cascode reference circuit.

Abstract: A method for treating a patient includes providing a delivery device capable of generating a magnetic field, placing the device above or below the skin, and directing the agent into the patient's skin via the device. The therapeutic agent is directed to a treatment site through the skin. Systems for directing agents are also included herein.

Abstract: A system for providing vehicle demos and conversations with product experts. The system activates an expert user chat in an expert user interface and activates a customer user chat in a customer user interface. The system further renders a three-dimensional (3D) model of a vehicle in the expert user interface and in the customer user interface. The system further renders controls in the expert user interface that enable an expert user to manipulate the 3D model in the expert user interface, and renders controls in the customer user interface that enable a customer user to manipulate the 3D model in the customer user interface.

Abstract: A system may selectively deliver interactive portions of a piece of content, based for example on a recipient user's historical tendency to use interactive portions of prior content. Multiple levels of interactivity may be defined for a given piece of content, such as an advertisement, and different users may receive different levels of interactivity based on how much they use interactive features. Some users may receive no interactive features at all, while others may receive the interactive features, and despite the fact that all of the users' devices may be perfectly capable of processing the interactive features for the user. The omission from transmission may conserve bandwidth and transmission resources.