Abstract: A method for automated spacecraft design includes receiving mission parameters provided by a client for spacecraft design, generating one or more concept designs based on the received mission parameters, each concept design including one or more components selected for each subsystem included in a designed spacecraft, for each concept design, generating a CAD model including a collection of CADs representing structures of the one or more components selected for each subsystem included in the designed spacecraft, performing a series of analyses or simulations to evaluate a performance of the CAD model, and generating a digital twin representing a virtual representation of the designed spacecraft.

Abstract: Disclosed herein are compounds of Formula (I), intermediates thereof, and methods for making the same: Also described herein are the use of such compounds and compositions for the treatment of diseases and disorders that are mediated, at least in part, by one or more cyclins, including cancer.

Abstract: A system and method for monitoring blood oxygen levels via an eye tracking camera includes a computer system with a processor configured to identify capillaries in the image stream of a pilot's eye. Changes in capillary size over time is directly correlated to blood flow levels. The processor may monitor capillary color. Changes in capillary color is directly correlated to blood oxygen levels. The processor may take remedial action when the pilot's blood oxygen level drops below a threshold. Such remedial action may include alerting the pilot, automatically alerting ground control crew, applying increasing levels of flight automation, etc.

Abstract: Disclosed herein are compounds of Formula I and methods for making the same: Also described herein are the use of such compounds, compositions for the treatment of diseases and disorders that are mediated, at least in part, by one or more cyclins, including cancer, and intermediates useful in the preparation of these compounds.

Abstract: A system includes a radio configured to transmit and receive voice transmissions to and from air traffic control (ATC), the radio installed onboard an aircraft. The system includes a processor communicatively coupled to the radio and installed onboard the aircraft. The processor is configured to: receive an ATC voice command via the radio; transcribe the ATC voice command into an ATC command; and when the ATC command includes an aircraft identification associated with the aircraft, categorize the ATC command into components, each of the components being categorized based on a criticality level associated with said component, wherein the criticality level is or is associated with a required accuracy confidence level of transcribed speech for a given component.

Abstract: An atraumatic insertion device for the subcutaneous delivery of pellet-shaped medicaments and/or implantable devices is described. The device includes a cannula with a distal tip that opens when the pellet-shaped medicaments and/or implantable devices are pushed through using an obturator. The cannula distal tip has at least three cuts, creating sectional leaves that open when pressure is applied distally from within the hollow cannula body. The distal tip of the obturator has complementary grooves to the sectional leaves of the cannula distal tip and will force everything out of the cannula and anything that might be caught on the sectional leaves. A blister packaging strip for storing and dispensing pellet-shaped medicaments and/or implantable devices is used to load the insertion device. The blister packaging strip has features to align the blister cavity directly above the loading well of the device and safely transfer the pellet-shaped medicaments and/or implantable devices into the cannula.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: Provided herein are systems and methods for automated generation of individual recommendations for medical treatment. The system and methods may ingest information from a variety of sources (e.g., clinical trials, tumor boards, case studies, etc.) and, based on this information, and a case summary provided by the physician, generate a ranked list of potential treatment options that are matched to the particular situation of a patient.

Abstract: A system includes a radio configured to transmit and receive voice transmissions to and from air traffic control (ATC), the radio installed onboard an aircraft. The system includes a processor communicatively coupled to the radio and installed onboard the aircraft. The processor is configured to: receive an ATC voice command via the radio; transcribe the ATC voice command into an ATC command; and when the ATC command includes an aircraft identification associated with the aircraft, categorize the ATC command into components, each of the components being categorized based on a criticality level associated with said component, wherein the criticality level is or is associated with a required accuracy confidence level of transcribed speech for a given component.

Abstract: Provided are systems and methods for dynamically transforming an unstructured document to a structured document prior to, during, or subsequent to transfer of information via the unstructured document. The transformation may be based on processing a variety of factors, such as the content of the unstructured document, request from a first party transferring the document, identity or characteristics of the first party, request from a second party requesting the document, and identity or characteristics of the second party.

Abstract: A propellant storage system that utilizes an integrated internal lattice structure within the fuel storage tank(s) to provide additional strength and anti-slosh features. The internal lattice structure lends its additional strength properties to adapt the fuel storage tank to unconventional geometries to allow for better compaction and weight savings in deployment vehicles such as satellites.

Abstract: Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters.

Abstract: Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.

Abstract: A system and method are disclosed for design of a suite of multispectral (MS) sensors and processing of enhanced data streams produced by the sensors for autonomous aircraft flight. The onboard suite of MS sensors is specifically configured to sense and use a MS variety of sensor-tuned objects, either strategically placed objects and/or surveyed and sensor significant existing objects to determine a position and verify position accuracy. The received MS sensor data enables an autonomous aircraft object identification and positioning system to correlate MS sensor data output with a-priori information stored onboard to determine and verify position and trajectory of the autonomous aircraft. Once position and trajectory are known, the object identification and positioning system commands the autonomous aircraft flight management system and autopilot control of the autonomous aircraft.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three-dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems.

Abstract: Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters.

Abstract: A method for generating an updated graph based on a base graph includes identifying differences between a base graph and each of a source and a target graph. The specification of each graph defines nodes representing data processing components defining operations for processing data, and links representing flow of data. The identifying includes: comparing specifications of base and source graphs to identify a first set of differences between the base and source graph, and comparing specifications of base and target graphs to identify a second set of differences between the base and the target graph. The method includes characterizing a correspondence between the differences in the first set and the differences in the second set, determining a set of combined differences based on the correspondence and the first and second sets of differences, and generating the updated graph based on the base graph and the set of combined differences.

Abstract: Disclosed are DNA/RNA hybrid nucleic acid nanoparticles comprising at least one trigger toehold or at least one exchange toehold, wherein each at least one trigger toehold and the at least one exchange toehold independently comprise DNA and/or RNA, and at least one single stranded RNA output strand, wherein no portion of the at least one trigger toehold hybridizes to any portion of the at least one output strand, the at least one trigger toehold is complementary and hybridizes to a first target sequence when the nanoparticle is in the presence of the first target sequence, and the nanoparticle does not contain the target sequence. Related pharmaceutical compositions, methods of treating a patient with a disease or condition, and methods of diagnosing a patient with a disease or condition are also disclosed.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe—Co alloy material (e.g., the Fe—Co—V alloy Hiperco-50®). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.