Abstract: A device for mixing and dispensing a flowable material or mixture of materials, the device comprising a cup having a bottom with a protrusion having an opening; a plunger having a dispensing port and air vent holes; a plug; a nozzle; and, a lid. The plug can be associated with and plug the cup protrusion opening when the cup is being filled or mixed, or the plug can be associated with the plunger port to seal off the air vent holes when material is dispensed from the device. Also disclosed is a method of mixing and dispensing a flowable material.

Abstract: Techniques for handling bulk file processing. One technique includes receiving a request to process transactions within a bulk file, consolidating the transactions into batches based on parameters used to define the transactions, processing a first set of exception validations for each of the batches, storing information for each of the batches that satisfies the first set of exception validations within a set of tables, processing, using JMS Queues and the set of tables, a second set of exception validations for each of the transactions within the batches that satisfy the first set of exception validations, collating, using a timer job and the set of tables, each of the transactions into subsequent batches based on whether each of the transactions satisfies or does not satisfies the second set of exception validations, and accounting each of the transactions in the subsequent batches that satisfy the second set of exception validations.

Abstract: Provide for herein are cyclic or linear peptides that bind HIV-1 capsid protein and inhibit HIV-1 capsid from assembling and/or disassembling. Further provided are methods of making said peptides and pharmaceutical compositions and methods for treating HIV infection.

Abstract: The present invention relates to an anti-CTLA4 conjugate or a pharmaceutically acceptable salt thereof, wherein said conjugate comprises a plurality of anti-CTLA4 moieties -D covalently conjugated via at least one moiety -L1-L2- to a polymeric moiety Z, wherein -L1- is covalently and reversibly conjugated to -D and -L2- is covalently conjugated to Z and wherein -L1- is a linker moiety and -L2- is a chemical bond or a spacer moiety; and related aspects.

Abstract: An edge connector for connecting to a mating connector includes an outer conductor having a main body and plug-in portion, and first and second inner-conductor contacts arranged at least partly inside the outer conductor. The inner-conductor contacts each comprise a coupling end and a contact end. A shortest spacing between the coupling end and the contact end of the first inner-conductor contact is different from a shortest spacing between the coupling end and the second contact of the second inner-conductor contact. The overall electrical lengths of the inner-conductor contacts are the same. The contact ends are arranged in parallel on a main plane and in the plug-in portion. The inner-conductor contacts are arranged at least partly inside a receiving chamber of the main body. The main plane divides the receiving chamber into first and second asymmetric chamber portions. An insulator galvanically isolates the inner-conductor contacts from the outer conductor.

Abstract: The invention provides a class of high RI polysiloxane vinylic crosslinkers. Each of the polysiloxane vinylic crosslinkers of the invention comprise (1) a polysiloxane segment comprising dimethylsiloxane units and aryl-containing siloxane units each having one methyl substituent and one organic substituent having up to 45 carbon atoms and at least one aryl moiety which is linked to Si atom through a linker having at least 2 (preferably 3) carbon atoms; (2) ethylenically-unsaturated groups. The invention also provides an insert or silicone hydrogel contact lens which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of high RI polysiloxane vinylic crosslinkers.

Abstract: A method for installing a guide assembly for a movable furniture part includes preferably carrying out chronologically in the following order: arranging on the furniture wall a first guide rail for guiding the movable furniture part, and arranging on a first longitudinal side of the first guide rail a drive device for influencing the movement of the movable furniture part on the furniture wall, the first guide rail and the drive device preferably being connected together. If the movable furniture part comprises at least two door leaves connected together in an articulated manner, arranging a second guide rail for guiding the movable furniture part on the furniture wall on a second longitudinal side of the first guide rail, the first guide rail and the second guide rail preferably being connected together in a form-fitting and/or movable manner in particular.

Abstract: Systems and methods for facilitating self-administered medical diagnostic tests and receiving treatment based on the results of such tests. In some examples, a user may take a medical diagnostic test under the supervision of a proctor over a video conference connection. The proctor or the system can verify the results of the test. The system can enable treatment based on the results of the test by, for example, facilitating the generation, fulfillment, and delivery of medication.

Abstract: A method for providing cleaning information for at least one surface of a medical imaging device. The method includes: recording contact data indicating contact between a person and at least one surface of the medical imaging device, wherein the contact data is recorded by at least one surface sensor unit; evaluating the contact data by an evaluation unit, wherein the evaluation of the contact data comprises identifying those surfaces of the medical imaging device which indicate a contact with and/or a physical proximity to a person; and generating cleaning information for the identified surfaces on the basis of the evaluated contact data and providing the cleaning information for the surfaces.

Abstract: The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF I R inhibitors. Exemplary SIK inhibitors include the compounds of the formula: (I), (II), (III), (IV), (V) or (VI).

Abstract: A method determines state information relating to a belt grinder. The belt grinder has at least one abrasive belt for grinding a workpiece. The method includes providing measurement data relating to the belt grinder, and determining the state information from the measurement data using a machine learning system. The machine learning system is configured to determine the state information based on the provided measurement data.

Abstract: Various aspects according to the instant disclosure relate to a method of electrodeposition of zinc. The method includes independently controlling at least one of an electrical peak current and a duty cycle. The method further includes depositing the zinc on a substrate.

Abstract: A surgical kit includes a handle assembly, an adapter assembly, and at least one end effector. The adapter assembly allows for use of a handle assembly that is configured to affect a function of a relatively long end effector to also be used with a relatively short end effector.

Abstract: A biomass upgrading process comprises a steam-cracking step for producing a granulated combustible product, and, prior to the granulation step, a step of mixing an intermediate pulverulent product resulting from the steam-cracking of the biomass and a pulverulent material having a high lignin content.

Abstract: Methods and systems for assessment and management of security in serverless environments are provided. One method includes executing an at least partially automated environment discovery process in which an overall security footprint of the enterprise is determined, and automatically identifying, via an enterprise security assessment tool, one or more security applications and associated settings capable of meeting the set of security requirements of the enterprise based on the sets of attributes associated with a plurality of serverless services.

Abstract: A method for deploying an application at a cluster of cloud nodes comprises receiving a component defining the deployment of the application at the cluster of cloud nodes, the component recursively defining a first graph of other components. A component has a mapping from an interface of the component to an interface of any component referenced in the component. The method comprises compiling the received component into instructions for input to an orchestrator of the cluster of cloud nodes; and sending the instructions to the orchestrator to trigger deployment of the application.

Abstract: The present disclosure relates to a cleaning assemblies, components thereof, and methods associated therewith for substrate processing chambers. In one example, a cleaning assembly for a substrate processing chamber includes a distribution ring. The distribution ring comprises a body with an inlet and an outlet. The outlet is fluidly coupled to an internal volume of the substrate processing chamber via a sidewall of the substrate processing chamber. The cleaning assembly includes a cleaning conduit configured to fluidly couple a gas manifold to the distribution ring for diverting a first portion of cleaning fluid from the gas manifold to the distribution ring.

Abstract: Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.

Abstract: The present disclosure provides a system for the expression of target protein in conjunction with enhancer protein. The enhancer protein may be a viral protein that blocks nucleocytoplasmic transport. Also provided are polynucleotides, vectors, and cells comprising target protein and enhancer protein nucleic acid sequences.

Abstract: An immersion-cooled battery including at least one module provided with a wireless communication system as an interface between a battery management system (BMS) and a data bus outside the module to ensure the tightness of the module. The module includes an enclosure filled with a cooling fluid into which electrochemical cells and the BMS are immersed. The wireless communication system, connected to the BMS, includes radiofrequency or optical wave emission and reception components, an inner unit and an outer unit, respectively located inside and outside the enclosure. The inner and outer units communicating through all-or-nothing raw signals propagating through at least one porthole embedded in a wall of the enclosure.