Abstract: The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.

Abstract: A storage, retrieval and processing system is disclosed for processing objects. The storage, retrieval and processing system includes a plurality of bins including objects to be distributed, the plurality of bins being provided on a conveyance system, a programmable motion device that includes an end effector for grasping and moving any of the objects, the programmable motion device being capable of reaching any of the objects within at least one of the plurality of bins in an input area of the conveyance system, a perception system for providing perception data regarding a selected object that is presented to the perception system by the programmable motion device, and a routing conveyance system including a track-mounted shuttle for receiving the selected object, and for moving the selected object in each of horizontal and vertical directions toward a destination container responsive to the perception data.

Abstract: A vehicle sensor system is described comprising an exterior surface; and a repellent composition disposed on the exterior surface, wherein the repellent composition exhibits an increase in haze according to the Dirty Water Spray Test of less than 5, 4, 3, or 2%. In typical embodiments, the repellent composition exhibits an advancing water contact angle from 90° to 125°. In some embodiments, the sensor system comprises a camera, a laser, a LIDAR sensor, a sonar sensor, or a radar sensor. The exterior surface is typically a windshield surface, a protective housing, or a lens surface. In some favored embodiments, the repellent composition exhibits a roll-off angle of no greater than 25, 20, 15, 10 or 5 degrees.

Abstract: A bender configured to bend a workpiece in a bending operation and its method of use are provided. The bender includes a frame, a bending shoe assembly rotatably mounted on the frame, a control system and a driver in communication therewith, and a springback assembly in communication with the control system and configured to provide information to the control system regarding information on a bend affected to the workpiece. The bending shoe assembly includes a bending shoe into which the workpiece can be seated, and a gripping member mounted on the bending shoe and configured to grip the workpiece during the bending operation. The driver provides rotational force to the bending shoe assembly to rotate the bending shoe assembly relative to the frame.

Abstract: A space vehicle is described. The space vehicle comprises one or more heat-producing components, and a closed loop cooling system configured to remove heat generated by the one or more heat-producing components. The closed loop cooling system comprises a coolant passageway defining a closed loop, a coolant located within the coolant passageway, the coolant comprising a static pressure of 100 pounds per square inch or lower and the coolant being in a single liquid phase through the coolant passageway, and one or more pumps configured to move the coolant through the coolant passageway. The closed loop cooling system further comprises a first heat exchange component disposed along the coolant passageway, the first heat exchange component configured to transfer heat from the heat-producing components to the coolant, and a second heat exchange component disposed along the coolant passageway, the second heat exchange component configured to remove heat from the coolant.

Abstract: A method, system and/or computer usable program product for managing optimization of a transportation network system including identifying a set of items for transportation between a set of origins and a set of destinations during a set of time periods, prioritizing each of the set of items, utilizing a set of network constraints and costs, utilizing a set of loading constraints for a set of transportation units, the loading constraints limiting the quantity and placement of items for each transportation unit, optimizing a quantity of the set of transportation units for transporting the set of items between the set of origins and the set of destinations during the set of time periods based on the prioritization of each of the set of items, the network constraints and costs, and the loading constraints for each transportation unit, and adjusting the optimized quantity of transportation units to a discrete quantity based on the prioritization of each of the set of items and the network constraints and costs.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: Example game systems and methods are described. In one implementation, a sensing device determines an identity of a game piece in a physical space and detects a movement action associated with the game piece. A computing device calculates a distance and direction associated with the movement action and determines a result of the movement action based on the distance, the direction, and the identity of the game piece.

Abstract: According to various embodiments, an all-optical thresholder device is disclosed. The all-optical thresholder device includes a Mach-Zehnder interferometer (MZI) coupled to a Mach-Zehnder coupler (MZC). The MZI includes at least one microring resonator (MRR) and a first tunable element, where the MRR further includes a second tunable element. The MZC includes a third tunable element. The first, second, and third tunable elements are configured to control biases of the all-optical thresholder device to achieve a desired power transfer function.

Abstract: Tooling and components of an injection-molding system may be used to mold a foam article. The tooling and components may include features that control parameters of the injection-molding and foaming process, such as temperature, pressure, shot size, shot placement, and the like.

Abstract: In an embodiment an optoelectronic lighting device includes a carrier, exactly one light-emitting optoelectronic semiconductor component, wherein the semiconductor component has a light emission area on at least one surface side, and wherein the semiconductor component is arranged on an upper side of the carrier, at least one functional layer arranged above the light emission area and/or adjacent to the light emission area and an edging for the functional layer, wherein the edging surrounds the functional layer when viewed in a circumferential direction, the circumferential direction being parallel to the upper side of the carrier around the functional layer, and wherein the edging is formed of a transparent material.

Abstract: The present disclosure provides various embodiments of a fluorescence scanning system having a sample holder with a sample suspended within that is rotated by a centrifuge such that the sample is illuminated at various angles by an excitation beam by operation of a galvanometer and such that the sample emits a fluorescence emissions that is detected through a narrow window of exposure defined along the travel path of rotation taken by the sample holder when rotated by the centrifuge. A stationary fluorescence detector is in operative communication with the sample holder along the narrow window of exposure for detecting the fluorescence emissions emitted by the sample from the sample holder while also separating the excitation beam from the fluorescence emissions.

Abstract: A system and method configured to enhance gameplay between users in an online game and to provide enhanced interest in virtual goods associated with collections of virtual goods through the ability to rotate drop rates associated with these virtual goods from time to time. The system and method includes the provision of functionality which allows providers of online games to periodically rotate drop rates associated with mystery boxes in order to maintain and/or generate additional interest in specific mystery boxes. As a result, it is possible for game operators to enhance revenue opportunities associated with these boxes even in the case where such boxes have been available for a relatively lengthy period of time and/or where players would have otherwise lost interest in specific boxes.

Abstract: The present disclosure relates to methods and apparatus for computer processing. Aspects of the present disclosure can determine at least one of a quality, latency, or capacity of a communication link for communication between a client device and a server. Aspects of the present disclosure can also determine a computational load for an application computation between the client device and the server. Moreover, aspects of the present disclosure can adjust a computational distribution for the application computation between the client device and the server based on at least one of the computational load for the application computation or the at least one of the quality, latency, or capacity of the communication link. Aspects of the present disclosure can also determine a computational capacity of at least one of the client device or the server.

Abstract: Provided are ulinastatin glycoforms, ulinastatin fusion polypeptides, and related compositions, mixtures, and methods of use, including methods of recombinantly producing ulinastatin polypeptides and treating diseases.

Abstract: Packaging for hydrated articles are generally provided. In some embodiments, packaged articles are provided. For example, in some embodiments, a container contains an article such as a catheter and/or polymeric material. The disclosed packaged articles may be useful for, for example, providing controlled humidity conditions for contained components, maintaining consistent hydration levels of the packaged articles, and/or improved sterilization conditions. Advantageously, the packaged articles described herein may, in some embodiments, create an environment with minimum relative humidity for long-term storage of a catheter or polymeric material, increase shelf life of the catheter or polymeric material, and/or facilitate hydration of a catheter such that e.g., the catheter hydrates to intended dimensions within a specified amount of time. Methods for preparing such packaged article are also provided.

Abstract: A machine learning system, in particular a deep neural network. The machine learning system includes a plurality of layers that are connected to one another. The layers each ascertain an output variable as a function of an input variable and at least one parameter that is stored in a memory. The parameters of those layers that are connected to a further, in particular preceding, layer are each stored in the memory using a higher resolution than the parameters of those layers that are connected to a plurality of further, in particular preceding, layers. In addition, A method, a computer program, and a device for creating the machine learning system, are described.

Abstract: A metal sintering preparation containing (A) 50 to 90% by weight of at least one metal that is present in the form of particles having a coating that contains at least one organic compound, and (B) 6 to 50% by weight organic solvent. The mathematical product of tamped density and specific surface of the metal particles of component (A) is in the range of 40,000 to 80,000 cm?1.

Abstract: Methods and systems for determining the integrity of a manufactured board are disclosed. An example system includes a testing platform configured to secure the manufactured board, a sensor configured to measure a parameter corresponding to a flatness of a surface of the board, and a controller. The controller is configured to identify regions on the surface corresponding to one of a peak or a valley based on the parameter, and calculate a score representing the integrity of the manufactured board based on the identified peaks and valleys. The controller adjusts a flow rate, a pressure, a temperature, and position of a deposited substance in a manufacturing process based on a comparison with a height of the peak and/or a depth of the valley to stored peak heights and/or valley depths. In some examples, a mechanical tester determines a compressive strength and a density of die board at the identified regions.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.